| Literature DB >> 30665115 |
Jo-Anne Bright1, Kevin Cheng2, Zane Kerr2, Catherine McGovern2, Hannah Kelly2, Tamyra R Moretti3, Michael A Smith3, Frederick R Bieber4, Bruce Budowle5, Michael D Coble5, Rashed Alghafri6, Paul Stafford Allen7, Amy Barber8, Vickie Beamer9, Christina Buettner10, Melanie Russell11, Christian Gehrig12, Tacha Hicks13, Jessica Charak14, Kate Cheong-Wing15, Anne Ciecko16, Christie T Davis17, Michael Donley18, Natalie Pedersen19, Bill Gartside20, Dominic Granger21, MaryMargaret Greer-Ritzheimer22, Erick Reisinger23, Jarrah Kennedy24, Erin Grammer25, Marla Kaplan26, David Hansen27, Hans J Larsen28, Alanna Laureano29, Christina Li30, Eugene Lien31, Emilia Lindberg32, Ciara Kelly33, Ben Mallinder34, Simon Malsom35, Alyse Yacovone-Margetts36, Andrew McWhorter37, Sapana M Prajapati38, Tamar Powell39, Gary Shutler40, Kate Stevenson2, April R Stonehouse41, Lindsey Smith42, Julie Murakami43, Eric Halsing44, Darren Wright45, Leigh Clark46, Duncan A Taylor47, John Buckleton48.
Abstract
An intra and inter-laboratory study using the probabilistic genotyping (PG) software STRmix™ is reported. Two complex mixtures from the PROVEDIt set, analysed on an Applied Biosystems™ 3500 Series Genetic Analyzer, were selected. 174 participants responded. For Sample 1 (low template, in the order of 200 rfu for major contributors) five participants described the comparison as inconclusive with respect to the POI or excluded him. Where LRs were assigned, the point estimates ranging from 2 × 104 to 8 × 106. For Sample 2 (in the order of 2000 rfu for major contributors), LRs ranged from 2 × 1028 to 2 × 1029. Where LRs were calculated, the differences between participants can be attributed to (from largest to smallest impact): This study demonstrates a high level of repeatability and reproducibility among the participants. For those results that differed from the mode, the differences in LR were almost always minor or conservative.Entities:
Keywords: Forensic DNA interpretation; Inter-laboratory study; Intra-laboratory study; Probabilistic genotyping; STRmix
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Year: 2019 PMID： 30665115 DOI： 10.1016/j.fsigen.2019.01.006
Source DB: PubMed Journal: Forensic Sci Int Genet ISSN： 1872-4973 Impact factor: 4.882