| Literature DB >> 30664993 |
Hossein Shahdadi Sardo1, Farinaz Saremnejad2, Sara Bagheri3, Abbas Akhgari4, Hadi Afrasiabi Garekani5, Fatemeh Sadeghi6.
Abstract
Site-specific colon drug delivery is a practical approach for the treatment of local diseases of the colon with several advantages such as rapid onset of action and reduction of the dosage of the drug as well as minimization of harmful side effects. 5-aminosalicylic acid (5-ASA) is a drug of choice in the treatment of inflammatory bowel disease and colitis. For the efficient delivery of this drug, it is vital to prevent 5-ASA release in the upper part of the gastrointestinal tract and to promote its release in the proximal colon. Different approaches including chemical manipulation of drug molecule for production of prodrugs or modification of drug delivery systems using pH-dependent, time-dependent and/or bacterially biodegradable materials have been tried to optimize 5-ASA delivery to the colon. In the current review, the different strategies utilized in the design and development of an oral colonic delivery dosage form of 5-ASA are presented and discussed.Entities:
Keywords: 5-ASA; Bacterial degradation approach; Colon delivery; Multiparticulate dosage form; Nanoparticulate systems; Prodrug; Single unit dosage form; Time-dependent approach; pH-dependent approach
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Year: 2019 PMID： 30664993 DOI： 10.1016/j.ijpharm.2019.01.022
Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875