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Literature DB >> 30664765

γδ TCR ligands: the quest to solve a 500-million-year-old mystery.

Abstract

γδ T cells have been retained as a lineage over the majority of vertebrate evolution, are able to respond to immune challenges in unique ways, and are of increasing therapeutic interest. However, one central mystery has endured: the identity of the ligands recognized by the γδ T cell antigen receptor. Here we discuss the inherent challenges in answering this question, the new opportunities provided by recent studies, and the criteria by which the field might judge success.

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Year: 2019 PMID： 30664765 DOI： 10.1038/s41590-018-0304-y

Source DB: PubMed Journal: Nat Immunol ISSN： 1529-2908 Impact factor: 25.606

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Cited

52 in total

1. Distinct and temporary-restricted epigenetic mechanisms regulate human αβ and γδ T cell development.

Authors: Juliette Roels; Anna Kuchmiy; Matthias De Decker; Steven Strubbe; Marieke Lavaert; Kai Ling Liang; Georges Leclercq; Bart Vandekerckhove; Filip Van Nieuwerburgh; Pieter Van Vlierberghe; Tom Taghon
Journal: Nat Immunol Date: 2020-07-27 Impact factor: 25.606

Review 2. T cell optimization for graft-versus-leukemia responses.

Authors: Melinda A Biernacki; Vipul S Sheth; Marie Bleakley
Journal: JCI Insight Date: 2020-05-07

3. Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine.

Authors: Luo Jia; Karen L Edelblum
Journal: J Vis Exp Date: 2019-06-24 Impact factor: 1.355

4. Clonal Vγ6⁺Vδ4⁺ T cells promote IL-17-mediated immunity against Staphylococcus aureus skin infection.

Authors: Mark C Marchitto; Carly A Dillen; Haiyun Liu; Robert J Miller; Nathan K Archer; Roger V Ortines; Martin P Alphonse; Alina I Marusina; Alexander A Merleev; Yu Wang; Bret L Pinsker; Angel S Byrd; Isabelle D Brown; Advaitaa Ravipati; Emily Zhang; Shuting S Cai; Nathachit Limjunyawong; Xinzhong Dong; Michael R Yeaman; Scott I Simon; Wei Shen; Scott K Durum; Rebecca L O'Brien; Emanual Maverakis; Lloyd S Miller
Journal: Proc Natl Acad Sci U S A Date: 2019-05-14 Impact factor: 11.205

5. Human γδ T cells recognize CD1b by two distinct mechanisms.

Authors: Josephine F Reijneveld; Tonatiuh A Ocampo; Adam Shahine; Benjamin S Gully; Pierre Vantourout; Adrian C Hayday; Jamie Rossjohn; D Branch Moody; Ildiko Van Rhijn
Journal: Proc Natl Acad Sci U S A Date: 2020-08-31 Impact factor: 11.205

6. Gastrin vaccine improves response to immune checkpoint antibody in murine pancreatic cancer by altering the tumor microenvironment.

Authors: Nicholas Osborne; Rebecca Sundseth; Julian Burks; Hong Cao; Xunxian Liu; Alexander H Kroemer; Lynda Sutton; Allen Cato; Jill P Smith
Journal: Cancer Immunol Immunother Date: 2019-09-24 Impact factor: 6.968

γδ TCR ligands: the quest to solve a 500-million-year-old mystery.

1. Distinct and temporary-restricted epigenetic mechanisms regulate human αβ and γδ T cell development.

Review 2. T cell optimization for graft-versus-leukemia responses.

3. Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine.

4. Clonal Vγ6⁺Vδ4⁺ T cells promote IL-17-mediated immunity against Staphylococcus aureus skin infection.

5. Human γδ T cells recognize CD1b by two distinct mechanisms.

6. Gastrin vaccine improves response to immune checkpoint antibody in murine pancreatic cancer by altering the tumor microenvironment.

Review 7. Crosstalk between γδ T cells and the microbiota.

8. The Nonmevalonate Pathway of Isoprenoid Biosynthesis Supports Anaerobic Growth of Listeria monocytogenes.

9. B7-H3 confers resistance to Vγ9Vδ2 T cell-mediated cytotoxicity in human colon cancer cells via the STAT3/ULBP2 axis.

Review 10. γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer.