| Literature DB >> 30663364 |
Le Hoang1,2, Vien Le Thi1, Hanh Tran Thi Hong1, Thanh Nguyen Van1, Cuong Nguyen Xuan1,2, Nam Nguyen Hoai1, Thung Do Cong3, Natalia V Ivanchina4, Thao Do Thi5, Pavel S Dmitrenok4, Alla A Kicha4, Kiem Phan Van1, Minh Chau Van1.
Abstract
From the MeOH extract of the Vietnamese sea cucumber Holothuria edulis, eight triterpene glycosides (1-8), including one new compound namely holothurin A5 (1), were isolated by using various chromatographic separations. Their structures were established by spectroscopic experiments including 1D, 2D NMR and HR-ESI-MS. Holothurin A5 (1) has a hydroperoxy group at C-25. To the best of our knowledge, this is the first report of this group in triterpene saponins obtained from sea cucumbers to date. In addition, the in vitro cytotoxicity against five human cancer cell lines (HepG2, KB, LNCaP, MCF7 and SK-Mel2) of all isolated compounds was also evaluated using SRB assays.Entities:
Keywords: Holothuria edulis; cytotoxicity; holothuriidae; triterpene glycoside
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Year: 2019 PMID： 30663364 DOI： 10.1080/14786419.2018.1548451
Source DB: PubMed Journal: Nat Prod Res ISSN： 1478-6419 Impact factor: 2.861