BACKGROUND AND OBJECTIVE: Bronchiolitis obliterans syndrome (BOS) after haematopoietic stem cell transplantation (HSCT) presents with lung function decline. The pattern of lung function decline after BOS diagnosis could impact prognostication of BOS as a complication after HSCT. The aim of this study was to assess the impact of lung function decline on overall survival (OS) in BOS subjects. METHODS: Subjects with BOS were compared to those without BOS and matched for age, gender, primary diagnoses, conditioning regimes and chronic graft versus host disease. Lung function tests at baseline, at BOS diagnosis and every 3 months after HSCT were evaluated. RESULTS: Of the 1461 subjects undergoing allogeneic HSCT (allo-HSCT) between 1998 and 2015, 95 (6.5%) were diagnosed with BOS. A total of 159 matched HSCT recipients without BOS were identified. A 25% decline in FEV1 within the first 3 months after BOS diagnosis would separate BOS subjects into a subgroup with initial rapid decline and another subgroup with initial gradual decline in lung function. The rapid decline group showed lower subsequent lung function parameters and significantly worse OS compared to the gradual decline group (P = 0.013). CONCLUSION: Post-HSCT BOS subjects with initial rapid lung function decline within 3 months after BOS diagnosis will have significantly poorer lung function and worse OS compared to those with initial gradual decline in lung function after BOS diagnosis. HSCT BOS patients with rapid initial decline in lung function warrant closer monitoring for the development of other post-HSCT complications that could affect their survival.
BACKGROUND AND OBJECTIVE:Bronchiolitis obliterans syndrome (BOS) after haematopoietic stem cell transplantation (HSCT) presents with lung function decline. The pattern of lung function decline after BOS diagnosis could impact prognostication of BOS as a complication after HSCT. The aim of this study was to assess the impact of lung function decline on overall survival (OS) in BOS subjects. METHODS: Subjects with BOS were compared to those without BOS and matched for age, gender, primary diagnoses, conditioning regimes and chronic graft versus host disease. Lung function tests at baseline, at BOS diagnosis and every 3 months after HSCT were evaluated. RESULTS: Of the 1461 subjects undergoing allogeneic HSCT (allo-HSCT) between 1998 and 2015, 95 (6.5%) were diagnosed with BOS. A total of 159 matched HSCT recipients without BOS were identified. A 25% decline in FEV1 within the first 3 months after BOS diagnosis would separate BOS subjects into a subgroup with initial rapid decline and another subgroup with initial gradual decline in lung function. The rapid decline group showed lower subsequent lung function parameters and significantly worse OS compared to the gradual decline group (P = 0.013). CONCLUSION: Post-HSCT BOS subjects with initial rapid lung function decline within 3 months after BOS diagnosis will have significantly poorer lung function and worse OS compared to those with initial gradual decline in lung function after BOS diagnosis. HSCT BOSpatients with rapid initial decline in lung function warrant closer monitoring for the development of other post-HSCT complications that could affect their survival.
Authors: Ajay Sheshadri; Amin Alousi; Lara Bashoura; Karen Stolar; Shiva Baghaie; Muhammad H Arain; Laila Noor; Amulya Balagani; Akash Jain; David Blanco; Abel Ortiz; Susan K Peterson; Renee Langhals; Michael Taylor; Alex Stenzler; Rohtesh S Mehta; Uday R Popat; Chitra Hosing; Gabriela Rondon; Fan Shen; Liang Li; Guang-Shing Cheng; David E Ost; Richard E Champlin; Burton F Dickey Journal: Ann Am Thorac Soc Date: 2020-10
Authors: Ajay Sheshadri; Sukh Makhnoon; Amin M Alousi; Lara Bashoura; Rene Andrade; Christopher J Miller; Karen R Stolar; Muhammad Hasan Arain; Laila Noor; Amulya Balagani; Akash Jain; David Blanco; Abel Ortiz; Michael S Taylor; Alex Stenzler; Rohtesh Mehta; Uday R Popat; Chitra Hosing; David E Ost; Richard E Champlin; Burton F Dickey; Susan K Peterson Journal: JMIR Form Res Date: 2022-02-07
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Authors: Shivanthan Shanthikumar; William A Gower; Matthew Abts; Deborah R Liptzin; Elizabeth K Fiorino; Anne Stone; Saumini Srinivasan; Timothy J Vece; Nour Akil; Theresa Cole; Kenneth R Cooke; Samuel B Goldfarb Journal: Cancer Rep (Hoboken) Date: 2021-07-28