Abubakar S Muhammad1, Ismaila A Mungadi1, Enemeka D Ndodu2, Garba D Kalayi3. 1. Urology Unit, Department of Surgery, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria. 2. Centre for Advanced Medical Research and Training, Usmanu Danfodiyo University Sokoto, Nigeria. 3. Urology Division, Department of Surgery, Ahmadu Bello University Teaching Hospital Zaria, Nigeria.
Abstract
OBJECTIVE: To compare the sensitivity, specificity, positive predictive value, negative predictive value of urinary survivin and that of urine cytology in the diagnosis of bladder carcinoma in a schistosoma endemic area. DESIGN AND SETTING: This is a 12-month prospective study of patients with features of bladder carcinoma as study group and patients with other urologic conditions and healthy volunteers as control group. PARTICIPANTS: Patients with features of bladder carcinoma formed the study group, while patients with other urological conditions and healthy volunteers formed the control group. RESULTS: There were 52 patients in study group and 36 patients in control group. The mean ages of patients in the study and control groups were 47.17 ± 17.00 and 44.19 ± 18.89 years respectively. There were 48 males and 4 females in the study group, giving a male: female ratio of 12:1. Thirty-one (60 %) of the patients were farmers and 44 patients (85%) had history suggestive of schistosomiasis at childhood. The sensitivity of urine cytology and survivin in the study were 29.1% and 100.0% respectively. The specificity of urine cytology and survivin were 100.0% and 100.0% respectively (p= 0.05). The marker was associated with false positive (FP) results in patients with prostate cancer. CONCLUSION: Urinary survivin is highly sensitive, specific and predictive of bladder carcinoma in our environment. The marker is associated with false positive results in patients with prostate cancer. FUNDING: By authors.
OBJECTIVE: To compare the sensitivity, specificity, positive predictive value, negative predictive value of urinary survivin and that of urine cytology in the diagnosis of bladder carcinoma in a schistosoma endemic area. DESIGN AND SETTING: This is a 12-month prospective study of patients with features of bladder carcinoma as study group and patients with other urologic conditions and healthy volunteers as control group. PARTICIPANTS: Patients with features of bladder carcinoma formed the study group, while patients with other urological conditions and healthy volunteers formed the control group. RESULTS: There were 52 patients in study group and 36 patients in control group. The mean ages of patients in the study and control groups were 47.17 ± 17.00 and 44.19 ± 18.89 years respectively. There were 48 males and 4 females in the study group, giving a male: female ratio of 12:1. Thirty-one (60 %) of the patients were farmers and 44 patients (85%) had history suggestive of schistosomiasis at childhood. The sensitivity of urine cytology and survivin in the study were 29.1% and 100.0% respectively. The specificity of urine cytology and survivin were 100.0% and 100.0% respectively (p= 0.05). The marker was associated with false positive (FP) results in patients with prostate cancer. CONCLUSION: Urinary survivin is highly sensitive, specific and predictive of bladder carcinoma in our environment. The marker is associated with false positive results in patients with prostate cancer. FUNDING: By authors.
Authors: Derya Tilki; Maximilian Burger; Guido Dalbagni; H Barton Grossman; Oliver W Hakenberg; Juan Palou; Oliver Reich; Morgan Rouprêt; Shahrokh F Shariat; Alexandre R Zlotta Journal: Eur Urol Date: 2011-06-12 Impact factor: 20.096
Authors: Omar Moussa; Hassan Abol-Enein; Nabil K Bissada; Thomas Keane; Mohamed A Ghoneim; Dennis K Watson Journal: J Urol Date: 2006-06 Impact factor: 7.450