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Literature DB >> 30661727

Prion Protein Antagonists Rescue Alzheimer's Amyloid-β-Related Cognitive Deficits.

Abhay P Sagare¹, Melanie D Sweeney¹, Amy R Nelson¹, Zhen Zhao², Berislav V Zlokovic³.

Abstract

Recent studies revealed that cellular prion protein on neurons bind Alzheimer's amyloid-β oligomers, causing neurotoxic effects. A new article in Cell Reports by Gunther and colleagues (Cell Rep. 2019; 26:145-158) shows that an orally administered cellular prion protein antagonist can rescue synaptic and cognitive deficits in Alzheimer's mice overexpressing amyloid-β.

Entities: Chemical Disease Gene Species

Keywords: Alzheimer’s disease; amyloid-β oligomers; antagonist; cellular prion protein; cognition

Year: 2019 PMID： 30661727 PMCID： PMC6377285 DOI： 10.1016/j.molmed.2019.01.001

Source DB: PubMed Journal: Trends Mol Med ISSN： 1471-4914 Impact factor: 11.951

12 in total

1. Cellular prion protein participates in amyloid-β transcytosis across the blood-brain barrier.

Authors: Thorsten Pflanzner; Benjamin Petsch; Bettina André-Dohmen; Andreas Müller-Schiffmann; Sabrina Tschickardt; Sascha Weggen; Lothar Stitz; Carsten Korth; Claus U Pietrzik
Journal: J Cereb Blood Flow Metab Date: 2012-02-01 Impact factor: 6.200

Review 2. Prions.

Authors: David W Colby; Stanley B Prusiner
Journal: Cold Spring Harb Perspect Biol Date: 2011-01-01 Impact factor: 10.005

3. Effects of Prion Protein on Aβ42 and Pyroglutamate-Modified AβpΕ3-42 Oligomerization and Toxicity.

Authors: Katiuscia Pagano; Denise Galante; Cristina D'Arrigo; Alessandro Corsaro; Mario Nizzari; Tullio Florio; Henriette Molinari; Simona Tomaselli; Laura Ragona
Journal: Mol Neurobiol Date: 2018-07-06 Impact factor: 5.590

4. Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone.

Authors: Silvia A Purro; Mark A Farrow; Jacqueline Linehan; Tamsin Nazari; David X Thomas; Zhicheng Chen; David Mengel; Takashi Saito; Takaomi Saido; Peter Rudge; Sebastian Brandner; Dominic M Walsh; John Collinge
Journal: Nature Date: 2018-12-13 Impact factor: 49.962

5. Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models.

Authors: Mikhail A Kostylev; Adam C Kaufman; Haakon B Nygaard; Pujan Patel; Laura T Haas; Erik C Gunther; Alexander Vortmeyer; Stephen M Strittmatter
Journal: J Biol Chem Date: 2015-05-27 Impact factor: 5.157

Review 6. Blood-Brain Barrier: From Physiology to Disease and Back.

Authors: Melanie D Sweeney; Zhen Zhao; Axel Montagne; Amy R Nelson; Berislav V Zlokovic
Journal: Physiol Rev Date: 2019-01-01 Impact factor: 37.312

7. Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouse.

Authors: Erika Chung; Yong Ji; Yanjie Sun; Richard J Kascsak; Regina B Kascsak; Pankaj D Mehta; Stephen M Strittmatter; Thomas Wisniewski
Journal: BMC Neurosci Date: 2010-10-14 Impact factor: 3.288

8. Rescue of Transgenic Alzheimer's Pathophysiology by Polymeric Cellular Prion Protein Antagonists.

Authors: Erik C Gunther; Levi M Smith; Mikhail A Kostylev; Timothy O Cox; Adam C Kaufman; Suho Lee; Ewa Folta-Stogniew; George D Maynard; Ji Won Um; Massimiliano Stagi; Jacqueline K Heiss; Austin Stoner; Geoff P Noble; Hideyuki Takahashi; Laura T Haas; John S Schneekloth; Janie Merkel; Christopher Teran; Zahra K Naderi; Surachai Supattapone; Stephen M Strittmatter
Journal: Cell Rep Date: 2019-01-29 Impact factor: 9.423

Prion Protein Antagonists Rescue Alzheimer's Amyloid-β-Related Cognitive Deficits.

1. Cellular prion protein participates in amyloid-β transcytosis across the blood-brain barrier.

Review 2. Prions.

3. Effects of Prion Protein on Aβ42 and Pyroglutamate-Modified AβpΕ3-42 Oligomerization and Toxicity.

4. Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone.

5. Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models.

Review 6. Blood-Brain Barrier: From Physiology to Disease and Back.

7. Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouse.

8. Rescue of Transgenic Alzheimer's Pathophysiology by Polymeric Cellular Prion Protein Antagonists.

9. Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers.

Review 10. Prion Protein as a Toxic Acceptor of Amyloid-β Oligomers.

Review 1. Peripheral Pathways to Neurovascular Unit Dysfunction, Cognitive Impairment, and Alzheimer's Disease.

Review 2. Neurodegeneration in type 2 diabetes: Alzheimer's as a case study.