Hyo Jung An1,2, Dae Hyun Song2,3,4, Hyun Min Koh2, Gyung Hyuck Ko3,4,5, Jeong-Hee Lee3,4,5, Dong Chul Kim3,4,5, Jung Wook Yang5, Min Hye Kim1,5, Deok Ha Seo1,6, Se Min Jang7, Jong Sil Lee3,4,5. 1. Department of Medicine, Gyeongsang National University College of Medicine, Jinju, Korea. 2. Department of Pathology, Gyeongsang National University Changwon Hospital, Changwon, Korea. 3. Gyeongsang National University School of Medicine, Jinju, Korea. 4. Gyeongsang Institute of Health Science, Jinju, Korea. 5. Department of Pathology, Gyeongsang National University Hospital, Jinju, Korea. 6. Department of Urology, Gyeongsang National University Changwon Hospital, Changwon, Korea. 7. Department of Pathology, Konyang University Hospital, Daejeon, Korea.
Abstract
AIM: To examine the expression of RAB27A and RAB27B in clear cell renal cell carcinoma (CCRCC). MATERIALS & METHODS: The intensity and proportion of tumor cells staining positive for RAB27A and RAB27B in a total of 304 cores were evaluated. RESULTS: The T stage showed a significant correlation with RAB27A intensity (p < 0.001). In multivariate analysis, CCRCC with negative intensity of RAB27A expression demonstrated poor disease-specific survival (hazard ratio: 6.821, 95% CI: 1.128-41.241; p-value = 0.036). CONCLUSION: RAB27A is an independent prognostic factor in CCRCC.
AIM: To examine the expression of RAB27A and RAB27B in clear cell renal cell carcinoma (CCRCC). MATERIALS & METHODS: The intensity and proportion of tumor cells staining positive for RAB27A and RAB27B in a total of 304 cores were evaluated. RESULTS: The T stage showed a significant correlation with RAB27A intensity (p < 0.001). In multivariate analysis, CCRCC with negative intensity of RAB27A expression demonstrated poor disease-specific survival (hazard ratio: 6.821, 95% CI: 1.128-41.241; p-value = 0.036). CONCLUSION:RAB27A is an independent prognostic factor in CCRCC.
Authors: Hyo Jung An; Jong Sil Lee; Jung Wook Yang; Min Hye Kim; Ji Min Na; Dae Hyun Song Journal: Cancer Genomics Proteomics Date: 2022 Sep-Oct Impact factor: 3.395