Ariana M Chao1,2, Thomas A Wadden2, Robert I Berkowitz3,4. 1. Department of Biobehavioral Health Sciences, University of Pennsylvania School of Nursing, Philadelphia, PA, USA. 2. Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. 3. Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. berkowitz@email.chop.edu. 4. Department of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia, 3440 Market Street, Suite 200, Philadelphia, PA, 19104, USA. berkowitz@email.chop.edu.
Abstract
PURPOSE OF REVIEW: This narrative review synthesized recent research related to obesity in adolescents with psychiatric disorders, with a focus on epidemiology, mechanisms, and weight management approaches. The paper reviews literature on depressive and anxiety disorders, bipolar disorder, and schizophrenia spectrum and other psychotic disorders. RECENT FINDINGS: Depression has a bidirectional relationship with obesity. Bipolar disorder and schizophrenia spectrum disorders, and their treatments, increase the risk of developing obesity. Mechanisms underlying this weight gain include lifestyle and environmental factors and psychiatric medications, though emerging evidence has also suggested the role of genetic and neuroendocrine processes. Evidence about the most effective treatments for obesity in adolescents with psychiatric disorders remains limited. Adolescents with psychiatric disorders are at high risk for obesity. Close monitoring for increases in weight and cardiometabolic risk factors with use of antipsychotic and mood-stabilizing medications is recommended. Clinical trials are needed that test the efficacy of weight management strategies for this population.
PURPOSE OF REVIEW: This narrative review synthesized recent research related to obesity in adolescents with psychiatric disorders, with a focus on epidemiology, mechanisms, and weight management approaches. The paper reviews literature on depressive and anxiety disorders, bipolar disorder, and schizophrenia spectrum and other psychotic disorders. RECENT FINDINGS:Depression has a bidirectional relationship with obesity. Bipolar disorder and schizophrenia spectrum disorders, and their treatments, increase the risk of developing obesity. Mechanisms underlying this weight gain include lifestyle and environmental factors and psychiatric medications, though emerging evidence has also suggested the role of genetic and neuroendocrine processes. Evidence about the most effective treatments for obesity in adolescents with psychiatric disorders remains limited. Adolescents with psychiatric disorders are at high risk for obesity. Close monitoring for increases in weight and cardiometabolic risk factors with use of antipsychotic and mood-stabilizing medications is recommended. Clinical trials are needed that test the efficacy of weight management strategies for this population.
Authors: Chen Hu; Ivan J Torres; Hong Qian; Hubert Wong; Priyanka Halli; Taj Dhanoa; Sharon Ahn; Gang Wang; David J Bond; Raymond W Lam; Lakshmi N Yatham Journal: J Affect Disord Date: 2016-10-11 Impact factor: 4.839
Authors: Jeffrey A Lieberman; T Scott Stroup; Joseph P McEvoy; Marvin S Swartz; Robert A Rosenheck; Diana O Perkins; Richard S E Keefe; Sonia M Davis; Clarence E Davis; Barry D Lebowitz; Joanne Severe; John K Hsiao Journal: N Engl J Med Date: 2005-09-19 Impact factor: 91.245
Authors: Scott B Teasdale; Philip B Ward; Simon Rosenbaum; Andrew Watkins; Jackie Curtis; Megan Kalucy; Katherine Samaras Journal: Br J Nutr Date: 2016-06 Impact factor: 3.718
Authors: Christoph U Correll; Peter Manu; Vladimir Olshanskiy; Barbara Napolitano; John M Kane; Anil K Malhotra Journal: JAMA Date: 2009-10-28 Impact factor: 56.272
Authors: Yuri Milaneschi; Femke Lamers; Wouter J Peyrot; Bernhard T Baune; Gerome Breen; Abbas Dehghan; Andreas J Forstner; Hans J Grabe; Georg Homuth; Carol Kan; Cathryn Lewis; Niamh Mullins; Matthias Nauck; Giorgio Pistis; Martin Preisig; Margarita Rivera; Marcella Rietschel; Fabian Streit; Jana Strohmaier; Alexander Teumer; Sandra Van der Auwera; Naomi R Wray; Dorret I Boomsma; Brenda W J H Penninx Journal: JAMA Psychiatry Date: 2017-12-01 Impact factor: 21.596
Authors: Katherine N Balantekin; Anne Claire Grammer; Ellen E Fitzsimmons-Craft; Dawn E Eichen; Andrea K Graham; Grace E Monterubio; Marie-Laure Firebaugh; Anna M Karam; Shiri Sadeh-Sharvit; Neha J Goel; Rachael E Flatt; Mickey T Trockel; C Barr Taylor; Denise E Wilfley Journal: Eat Behav Date: 2021-02-13
Authors: Matthew J Gurka; Siraj U Siddiqi; Stephanie L Filipp; Rebeccah Mercado; Lindsay A Thompson; David M Janicke; Elizabeth A Shenkman Journal: Pediatr Obes Date: 2020-10-16 Impact factor: 4.000