Alexander Vargas-Hernández1,2, Lisa R Forbes3,4. 1. Department of Pediatrics, Immunology Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, USA. 2. Center for Human Immunobiology, William T Shearer Center for Human Immunobiology, Texas Children's Hospital, 1102 Bates Ave, Suite 330, Houston, TX, 77030, USA. 3. Department of Pediatrics, Immunology Allergy and Rheumatology, Baylor College of Medicine, Houston, TX, USA. lisa.forbes@bcm.edu. 4. Center for Human Immunobiology, William T Shearer Center for Human Immunobiology, Texas Children's Hospital, 1102 Bates Ave, Suite 330, Houston, TX, 77030, USA. lisa.forbes@bcm.edu.
Abstract
PURPOSE OF REVIEW: Natural killer cells are innate lymphoid cells (ILCs) that play critical roles in human host defense and are especially useful in combating viral pathogens and malignancy. RECENT FINDINGS: The NK cell deficiency (NKD) is particularly underscored in patients with a congenital immunodeficiency in which NK cell development or function is affected. The classical NK cell deficiency (cNKD) is a result of absent or a profound decrease in the number of circulating NK cells. In contrast, functional NKD (fNKD) is characterized by abnormal NK cell function but with normal number of NK cells. The combined immune deficiencies with significant impact on NK cells are not considered classical or functional NK cell deficiencies. In these disorders, the impairment of NK cells represents an important aspect of the overall immunodeficiency. In turn, this leads to improved insights on the NK cell development and function. Here, we detail the NK cell biology based upon recent natural killer cell defects described in combined immune deficiencies.
PURPOSE OF REVIEW: Natural killer cells are innate lymphoid cells (ILCs) that play critical roles in human host defense and are especially useful in combating viral pathogens and malignancy. RECENT FINDINGS: The NK cell deficiency (NKD) is particularly underscored in patients with a congenital immunodeficiency in which NK cell development or function is affected. The classical NK cell deficiency (cNKD) is a result of absent or a profound decrease in the number of circulating NK cells. In contrast, functional NKD (fNKD) is characterized by abnormal NK cell function but with normal number of NK cells. The combined immune deficiencies with significant impact on NK cells are not considered classical or functional NK cell deficiencies. In these disorders, the impairment of NK cells represents an important aspect of the overall immunodeficiency. In turn, this leads to improved insights on the NK cell development and function. Here, we detail the NK cell biology based upon recent natural killer cell defects described in combined immune deficiencies.
Entities:
Keywords:
NK cell deficiency; Natural killer cells
Authors: Raquel Ruiz-García; Alexander Vargas-Hernández; Ivan K Chinn; Laura S Angelo; Tram N Cao; Zeynep Coban-Akdemir; Shalini N Jhangiani; Qingchang Meng; Lisa R Forbes; Donna M Muzny; Luis M Allende; Mohammed S Ehlayel; Richard A Gibbs; James R Lupski; Gulbu Uzel; Jordan S Orange; Emily M Mace Journal: J Allergy Clin Immunol Date: 2018-01-10 Impact factor: 10.793
Authors: Katja G Weinacht; Louis-Marie Charbonnier; Fayhan Alroqi; Ashley Plant; Qi Qiao; Hao Wu; Clement Ma; Troy R Torgerson; Sergio D Rosenzweig; Thomas A Fleisher; Luigi D Notarangelo; Imelda C Hanson; Lisa R Forbes; Talal A Chatila Journal: J Allergy Clin Immunol Date: 2017-01-27 Impact factor: 10.793
Authors: Gillian L Dornan; Braden D Siempelkamp; Meredith L Jenkins; Oscar Vadas; Carrie L Lucas; John E Burke Journal: Proc Natl Acad Sci U S A Date: 2017-02-06 Impact factor: 11.205
Authors: Emily M Mace; Amy P Hsu; Linda Monaco-Shawver; George Makedonas; Joshua B Rosen; Lesia Dropulic; Jeffrey I Cohen; Eugene P Frenkel; John C Bagwell; John L Sullivan; Christine A Biron; Christine Spalding; Christa S Zerbe; Gulbu Uzel; Steven M Holland; Jordan S Orange Journal: Blood Date: 2013-01-30 Impact factor: 22.113
Authors: María Soledad Caldirola; María Guadalupe Rodríguez Broggi; María Isabel Gaillard; Liliana Bezrodnik; Norberto Walter Zwirner Journal: Front Immunol Date: 2018-06-22 Impact factor: 7.561