| Literature DB >> 30660992 |
Mónica Daniela Mora-Ruíz1, Francisco Blanco-Favela1, Adriana Karina Chávez Rueda1, María Victoria Legorreta-Haquet1, Luis Chávez-Sánchez2.
Abstract
Acute myocardial infarction (AMI) is a leading cause of death worldwide. Myocardial necrosis generates damage signals and triggers an intense inflammatory response. Many cytokines that contribute to repair tissue can also cause adverse left ventricular remodeling and heart failure. Several studies have revealed that interleukin-17 (IL-17) is a cytokine with a potential role in AMI. IL-17 plays an important role in the immune response and affects the production of different inflammatory mediators in several types of cells, involved in the damage or scar process in myocardial tissue. In this review, we will discuss the current knowledge of the role of IL-17 in AMI and the effect of IL-17 in different cells, such as cardiomyocytes, smooth muscle cells and immune system cells, in AMI pathogenesis.Entities:
Keywords: Acute myocardial infarction; Inflammation; Interleukin-17
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Year: 2019 PMID： 30660992 DOI： 10.1016/j.molimm.2019.01.008
Source DB: PubMed Journal: Mol Immunol ISSN： 0161-5890 Impact factor: 4.407