BACKGROUND: We assessed the impact of comorbid depression and anxiety disorders as well as positive and negative emotional states on alcohol consumption in alcohol dependent men and women. METHODS: Per day alcohol consumption during 90 days before enrolment was assessed by the Time Line Follow Back (TLFB) in 287 men and 156 women meeting DSM-IV-TR criteria for alcohol dependence. Propensity to drink in negative/positive emotional states was assessed using the Inventory of Drug Taking Situations (IDTS). Psychiatric comorbidities, including major depressive disorder (MDD), substance-induced depression (SID), anxiety disorders (AnxD), or substance-induced anxiety (SIA) were identified by Psychiatric Research Interview of Substance and Mood Disorders (PRISM). RESULTS: In the combined group, increased number of drinks per day and number of heavy drinking days correlated with increased IDTS scores (all p < 0.0001), while the lifetime history of MDD was associated with fewer drinking days (p = 0.045) but not average number of drinks per day. Male sex was associated with higher alcohol consumption per day (p < 0.0001), but not with the number of drinking days (p > 0.05). Lifetime MDD history was associated with less drinking days (p = 0.0084) and less heavy drinking days (p = 0.021) in alcohol dependent men, while current MDD was associated with higher alcohol use per day in alcohol dependent women (p = 0.044). CONCLUSIONS: Our findings suggest that emotional states and lifetime MDD history have sex-specific impact on alcohol use in alcohol dependent men and women. The mechanisms underlying these findings and their relevance to treatment outcomes need to be examined in future studies.
BACKGROUND: We assessed the impact of comorbid depression and anxiety disorders as well as positive and negative emotional states on alcohol consumption in alcohol dependent men and women. METHODS: Per day alcohol consumption during 90 days before enrolment was assessed by the Time Line Follow Back (TLFB) in 287 men and 156 women meeting DSM-IV-TR criteria for alcohol dependence. Propensity to drink in negative/positive emotional states was assessed using the Inventory of Drug Taking Situations (IDTS). Psychiatric comorbidities, including major depressive disorder (MDD), substance-induced depression (SID), anxiety disorders (AnxD), or substance-induced anxiety (SIA) were identified by Psychiatric Research Interview of Substance and Mood Disorders (PRISM). RESULTS: In the combined group, increased number of drinks per day and number of heavy drinking days correlated with increased IDTS scores (all p < 0.0001), while the lifetime history of MDD was associated with fewer drinking days (p = 0.045) but not average number of drinks per day. Male sex was associated with higher alcohol consumption per day (p < 0.0001), but not with the number of drinking days (p > 0.05). Lifetime MDD history was associated with less drinking days (p = 0.0084) and less heavy drinking days (p = 0.021) in alcohol dependent men, while current MDD was associated with higher alcohol use per day in alcohol dependent women (p = 0.044). CONCLUSIONS: Our findings suggest that emotional states and lifetime MDD history have sex-specific impact on alcohol use in alcohol dependent men and women. The mechanisms underlying these findings and their relevance to treatment outcomes need to be examined in future studies.
Authors: Dvora Shmulewitz; Efrat Aharonovich; Katie Witkiewitz; Raymond F Anton; Henry R Kranzler; Jennifer Scodes; Karl F Mann; Melanie M Wall; Deborah Hasin Journal: Am J Psychiatry Date: 2021-01-21 Impact factor: 19.242
Authors: Ming-Fen Ho; Cheng Zhang; Lixuan Wei; Lingxin Zhang; Irene Moon; Jennifer R Geske; Michelle K Skime; Doo-Sup Choi; Joanna M Biernacka; Tyler S Oesterle; Mark A Frye; Marvin D Seppala; Victor M Karpyak; Hu Li; Richard M Weinshilboum Journal: Br J Pharmacol Date: 2022-02-08 Impact factor: 9.473
Authors: Ming-Fen Ho; Cheng Zhang; Irene Moon; Brandon J Coombes; Joanna Biernacka; Michelle Skime; Doo-Sup Choi; Paul E Croarkin; Mark A Frye; Quyen Ngo; Cedric Skillon; Tyler S Oesterle; Victor M Karpyak; Hu Li; Richard M Weinshilboum Journal: Front Pharmacol Date: 2022-09-01 Impact factor: 5.988
Authors: Robert Hitzemann; Susan E Bergeson; Ari E Berman; Jason A Bubier; Elissa J Chesler; Deborah A Finn; Matthew Hein; Paula Hoffman; Andrew Holmes; Brent R Kisby; Denesa Lockwood; Kerrie H Lodowski; Michelle McManus; Julie A Owen; Angela R Ozburn; Praneetha Panthagani; Igor Ponomarev; Laura Saba; Boris Tabakoff; Aashlesha Walchale; Robert W Williams; Tamara J Phillips Journal: Biol Psychiatry Date: 2021-05-01 Impact factor: 12.810