Valerio Da Ros1, Jonathan Cortese2, Olivier Chassin3, Aymeric Rouchaud2, Mariana Sarov3, Jildaz Caroff2, Cristian Mihalea4, Silvia Minosse5, Irina Taifas3, Jacopo Scaggiante5, Laura Greco5, Leon Ikka2, Nidhal Ben Achour2, Francesca Di Giuliano5, Augustin Ozanne2, Nicolas Legris3, Marina Diomedi6, Fabrizio Sallustio6, Roberto Floris5, Christian Denier3, Laurent Spelle2. 1. Department of diagnostic imaging and interventional radiology, "Tor Vergata" university Hospital, viale Oxford, 81, 00133 Rome, Italy; Interventional Neuroradiology NEURI Center, Hôpital Bicêtre, 78, rue du Général-Leclerc, 94270 Le Kremlin Bicêtre, France. Electronic address: darosvalerio@gmail.com. 2. Interventional Neuroradiology NEURI Center, Hôpital Bicêtre, 78, rue du Général-Leclerc, 94270 Le Kremlin Bicêtre, France. 3. Department of Neurology, Bicêtre Hospital, 78, rue du Général-Leclerc, 94270 Le Kremlin-Bicêtre, Paris, France. 4. Department of diagnostic imaging and interventional radiology, "Tor Vergata" university Hospital, viale Oxford, 81, 00133 Rome, Italy; Interventional Neuroradiology NEURI Center, Hôpital Bicêtre, 78, rue du Général-Leclerc, 94270 Le Kremlin Bicêtre, France. 5. Department of diagnostic imaging and interventional radiology, "Tor Vergata" university Hospital, viale Oxford, 81, 00133 Rome, Italy. 6. Department of Neurology, Stroke Unit, "Tor Vergata" University Hospital, viale Oxford, 81, 00133 Rome, Italy.
Abstract
BACKGROUND AND PURPOSE: To compare outcomes of minor stroke patients with intracranial vessel occlusions (IVO) underwent mechanical thrombectomy (MT) versus those treated with intravenous thrombolysis alone (IVT). METHODS: We retrospectively reviewed two large prospective stroke databases from two European centers searching for patients admitted with minor stroke (i.e. NIHSS Score░≤░5), baseline mRS░=░0 and occlusion of the M1-M2 segment of the middle cerebral artery (MCA). Groups receiving (A) IVT alone and (B) MT+/-IVT were compared. Primary outcome measures were MT safety, successful recanalization rate (mTICI 2b-3) and NIHSS shift (discharge NIHSS minus admission NIHSS); secondary outcomes included discharge rates and excellent outcome (mRS 0-1) at 3 months. Univariate and multivariate analyses were performed. RESULTS: Thirty-two patients were enrolled in Group B (19░MT alone; 13 MT░+░IVT) and 24 in Group A. Successful recanalization (mTICI 2b-3) was obtained in 100% of cases in Group B vs 38% in Group A. Symptomatic hemorrhagic transformation rate did not differ between the two groups. Multivariate analysis reported MT as the only predictor of early (<░12░h) favorable NIHSS shift and lower NIHSS at discharge. Moreover, discharge at home and excellent outcome at 3-month follow-up were statistically associated with MT. CONCLUSIONS: MT in patients with minor strokes and intracranial vessel occlusion (IVO) is safe and can determine a rapid improvement of NIHSS Score. MT seems also associated with a higher rate of patients discharged at home after hospitalization and better clinical outcome at 3-month follow-up. Larger randomized trials are warranted to confirm these results.
BACKGROUND AND PURPOSE: To compare outcomes of minor strokepatients with intracranial vessel occlusions (IVO) underwent mechanical thrombectomy (MT) versus those treated with intravenous thrombolysis alone (IVT). METHODS: We retrospectively reviewed two large prospective stroke databases from two European centers searching for patients admitted with minor stroke (i.e. NIHSS Score░≤░5), baseline mRS░=░0 and occlusion of the M1-M2 segment of the middle cerebral artery (MCA). Groups receiving (A) IVT alone and (B) MT+/-IVT were compared. Primary outcome measures were MT safety, successful recanalization rate (mTICI 2b-3) and NIHSS shift (discharge NIHSS minus admission NIHSS); secondary outcomes included discharge rates and excellent outcome (mRS 0-1) at 3 months. Univariate and multivariate analyses were performed. RESULTS: Thirty-two patients were enrolled in Group B (19░MT alone; 13 MT░+░IVT) and 24 in Group A. Successful recanalization (mTICI 2b-3) was obtained in 100% of cases in Group B vs 38% in Group A. Symptomatic hemorrhagic transformation rate did not differ between the two groups. Multivariate analysis reported MT as the only predictor of early (<░12░h) favorable NIHSS shift and lower NIHSS at discharge. Moreover, discharge at home and excellent outcome at 3-month follow-up were statistically associated with MT. CONCLUSIONS: MT in patients with minor strokes and intracranial vessel occlusion (IVO) is safe and can determine a rapid improvement of NIHSS Score. MT seems also associated with a higher rate of patients discharged at home after hospitalization and better clinical outcome at 3-month follow-up. Larger randomized trials are warranted to confirm these results.