Nguyen-Son Le1, Stefan Janik1, Helmut Simmel2, Boban M Erovic3. 1. Department of Otorhinolaryngology and Head and Neck Surgery, Medical University of Vienna, Vienna, Austria. 2. Department of Radio-Oncology, Kaiser-Franz-Josef Hospital, Vienna, Austria. 3. Department of Head and Neck Diseases, Evangelical Hospital Vienna, Vienna, Austria.
Abstract
BACKGROUND: The purpose of this study was to analyze and compare ipsilateral and bilateral adjuvant radiotherapy in patients with cancer of unknown primary (CUP) of the head and neck. METHODS: Overall survival, recurrence-free survival, and radiation-induced side effects were assessed in 76 patients with CUP who underwent ipsilateral (n = 29) or bilateral (n = 47) radiotherapy. RESULTS: At a median follow-up of 41 months, the 5-year overall survival and recurrence-free rate were 67.9% and 71.5%, respectively. No statistically significant difference between ipsilateral and bilateral radiotherapy could be found regarding 5-year overall survival, recurrence-free survival, occurrence of a primary tumor, and distant metastasis. The analysis of radiation-induced acute side effects showed a significant benefit of ipsilateral radiotherapy. CONCLUSION: As the main parameters of the study regarding the outcome and radiation-induced side effects showed no advantages of bilateral radiotherapy, the strategy of ipsilateral radiotherapy can be recommended for the adjuvant treatment of CUP patients.
BACKGROUND: The purpose of this study was to analyze and compare ipsilateral and bilateral adjuvant radiotherapy in patients with cancer of unknown primary (CUP) of the head and neck. METHODS: Overall survival, recurrence-free survival, and radiation-induced side effects were assessed in 76 patients with CUP who underwent ipsilateral (n = 29) or bilateral (n = 47) radiotherapy. RESULTS: At a median follow-up of 41 months, the 5-year overall survival and recurrence-free rate were 67.9% and 71.5%, respectively. No statistically significant difference between ipsilateral and bilateral radiotherapy could be found regarding 5-year overall survival, recurrence-free survival, occurrence of a primary tumor, and distant metastasis. The analysis of radiation-induced acute side effects showed a significant benefit of ipsilateral radiotherapy. CONCLUSION: As the main parameters of the study regarding the outcome and radiation-induced side effects showed no advantages of bilateral radiotherapy, the strategy of ipsilateral radiotherapy can be recommended for the adjuvant treatment of CUP patients.
Authors: Muhammad Faisal; Nguyen-Son Le; Stefan Grasl; Stefan Janik; Helmut Simmel; Annemarie U Schratter-Sehn; Jafar-Sasan Hamzavi; Peter Franz; Boban M Erovic Journal: Diagnostics (Basel) Date: 2022-04-03
Authors: Muhammad Faisal; Rudolf Seemann; Claudia Lill; Sasan Hamzavi; Arno Wutzl; Boban M Erovic; Stefan Janik Journal: Head Neck Date: 2020-01-10 Impact factor: 3.147
Authors: Alexis Platek; Michael Mix; Varun Chowdhry; Mark Farrugia; Michael A Lacombe; Jeffrey A Bogart; Luke Degraaf; Austin Iovoli; Hassan Arshad; Kimberly Wooten; Vishal Gupta; Wesley L Hicks; Mary E Platek; Seung S Hahn; Anurag K Singh Journal: PLoS One Date: 2020-04-10 Impact factor: 3.240
Authors: Olgun Elicin; Paul Martin Putora; Marco Siano; Martina A Broglie; Christian Simon; Daniel Zwahlen; Gerhard F Huber; Giorgio Ballerini; Lorenza Beffa; Roland Giger; Sacha Rothschild; Sandro V Negri; Pavel Dulguerov; Guido Henke Journal: Front Oncol Date: 2019-10-24 Impact factor: 6.244