Literature DB >> 30659536

A Journey through the Cytoskeleton with Protein Kinase CK2.

Claudio D'Amore1, Valentina Salizzato1,2, Christian Borgo1, Luca Cesaro1, Lorenzo A Pinna1,2, Mauro Salvi1.   

Abstract

Substrate pleiotropicity, a very acidic phosphorylation consensus sequence, and an apparent uncontrolled activity, are the main features of CK2, a Ser/Thr protein kinase that is required for a plethora of cell functions. Not surprisingly, CK2 appears to affect cytoskeletal structures and correlated functions such as cell shape, mechanical integrity, cell movement and division. This review outlines our current knowledge of how CK2 regulates cytoskeletal structures, and discusses involved pathways and molecular mechanisms. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Keywords:  Post-translational modifications; acidic phosphorylation; actin; casein kinase 2; septin; tubulin.

Mesh：

Substances：

Year:  2019        PMID： 30659536     DOI： 10.2174/1389203720666190119124846

Source DB:  PubMed          Journal:  Curr Protein Pept Sci        ISSN： 1389-2037            Impact factor:   3.272


  12 in total

1.  The Global Phosphorylation Landscape of SARS-CoV-2 Infection.

Authors:  Mehdi Bouhaddou; Danish Memon; Bjoern Meyer; Kris M White; Veronica V Rezelj; Miguel Correa Marrero; Benjamin J Polacco; James E Melnyk; Svenja Ulferts; Robyn M Kaake; Jyoti Batra; Alicia L Richards; Erica Stevenson; David E Gordon; Ajda Rojc; Kirsten Obernier; Jacqueline M Fabius; Margaret Soucheray; Lisa Miorin; Elena Moreno; Cassandra Koh; Quang Dinh Tran; Alexandra Hardy; Rémy Robinot; Thomas Vallet; Benjamin E Nilsson-Payant; Claudia Hernandez-Armenta; Alistair Dunham; Sebastian Weigang; Julian Knerr; Maya Modak; Diego Quintero; Yuan Zhou; Aurelien Dugourd; Alberto Valdeolivas; Trupti Patil; Qiongyu Li; Ruth Hüttenhain; Merve Cakir; Monita Muralidharan; Minkyu Kim; Gwendolyn Jang; Beril Tutuncuoglu; Joseph Hiatt; Jeffrey Z Guo; Jiewei Xu; Sophia Bouhaddou; Christopher J P Mathy; Anna Gaulton; Emma J Manners; Eloy Félix; Ying Shi; Marisa Goff; Jean K Lim; Timothy McBride; Michael C O'Neal; Yiming Cai; Jason C J Chang; David J Broadhurst; Saker Klippsten; Emmie De Wit; Andrew R Leach; Tanja Kortemme; Brian Shoichet; Melanie Ott; Julio Saez-Rodriguez; Benjamin R tenOever; R Dyche Mullins; Elizabeth R Fischer; Georg Kochs; Robert Grosse; Adolfo García-Sastre; Marco Vignuzzi; Jeffery R Johnson; Kevan M Shokat; Danielle L Swaney; Pedro Beltrao; Nevan J Krogan
Journal:  Cell       Date:  2020-06-28       Impact factor: 41.582

Review 2.  CK2 and the Hallmarks of Cancer.

Authors:  May-Britt Firnau; Angela Brieger
Journal:  Biomedicines       Date:  2022-08-16

3.  Tunneling nanotubes provide a route for SARS-CoV-2 spreading.

Authors:  Anna Pepe; Stefano Pietropaoli; Matthijn Vos; Giovanna Barba-Spaeth; Chiara Zurzolo
Journal:  Sci Adv       Date:  2022-07-20       Impact factor: 14.957

Review 4.  Phosphoregulation of Kinesins Involved in Long-Range Intracellular Transport.

Authors:  Diksha Kumari; Krishanu Ray
Journal:  Front Cell Dev Biol       Date:  2022-06-03

5.  Protein Kinase CK2 Subunits Differentially Perturb the Adhesion and Migration of GN11 Cells: A Model of Immature Migrating Neurons.

Authors:  Antonella Lettieri; Christian Borgo; Luca Zanieri; Claudio D'Amore; Roberto Oleari; Alyssa Paganoni; Lorenzo A Pinna; Anna Cariboni; Mauro Salvi
Journal:  Int J Mol Sci       Date:  2019-11-26       Impact factor: 5.923

6.  4,5,7-Trisubstituted indeno[1,2-b]indole inhibits CK2 activity in tumor cells equivalent to CX-4945 and shows strong anti-migratory effects.

Authors:  Robin Birus; Ehab El-Awaad; Laurens Ballentin; Faten Alchab; Dagmar Aichele; Laurent Ettouati; Claudia Götz; Marc Le Borgne; Joachim Jose
Journal:  FEBS Open Bio       Date:  2021-12-18       Impact factor: 2.693

7.  CX-4945 and siRNA-Mediated Knockdown of CK2 Improves Cisplatin Response in HPV(+) and HPV(-) HNSCC Cell Lines.

Authors:  Janeen H Trembley; Bin Li; Betsy T Kren; Amy A Gravely; Emiro Caicedo-Granados; Mark A Klein; Khalil Ahmed
Journal:  Biomedicines       Date:  2021-05-18

8.  Broad-Spectrum Anticancer Activity and Pharmacokinetic Properties of a Prenyloxy-Substituted Indeno[1,2-b]indole Derivative, Discovered as CK2 Inhibitor.

Authors:  Ehab El-Awaad; Robin Birus; Christelle Marminon; Zouhair Bouaziz; Laurens Ballentin; Dagmar Aichele; Marc Le Borgne; Joachim Jose
Journal:  Pharmaceuticals (Basel)       Date:  2021-06-05

9.  Synergistic Interactions of 5-Fluorouracil with Inhibitors of Protein Kinase CK2 Correlate with p38 MAPK Activation and FAK Inhibition in the Triple-Negative Breast Cancer Cell Line.

Authors:  Patrycja Wińska; Olena Karatsai; Monika Staniszewska; Mirosława Koronkiewicz; Konrad Chojnacki; Maria Jolanta Rędowicz
Journal:  Int J Mol Sci       Date:  2020-08-28       Impact factor: 5.923

Review 10.  Role of CK2 inhibitor CX-4945 in anti-cancer combination therapy - potential clinical relevance.

Authors:  Claudio D'Amore; Christian Borgo; Stefania Sarno; Mauro Salvi
Journal:  Cell Oncol (Dordr)       Date:  2020-10-14       Impact factor: 6.730
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