| Literature DB >> 30658745 |
Jackeline Cintra Soares1, Pedro Luiz Rosalen2, Josy Goldoni Lazarini2, Adna Prado Massarioli1, Camila Fortunato da Silva1, Bruno Dias Nani2, Marcelo Franchin2, Severino Matias de Alencar3.
Abstract
Brazilian native fruits (BNF) remain unexplored and underutilized resources with a high potential to improve human health and wellness. In our study, five new BNF (Eugenia stipitata, Sageretia elegans, Byrsonima arthropoda, Spondias mombin andRubus rosaefolius)were evaluated for their phenolic composition by LC-ESI-QTOF-MS; and for their ROS and RNS scavenging effects (ROO, O2-, NO, HOCl); in vivo anti-inflammatory activity (neutrophil migration); and in vivo acute toxicity in Galleria mellonella. Eighty-six phenolic compounds were identified, including hydroxybenzoic acids, hydroxycinnamic acids, flavonoids, anthocyanins and ellagitannins, several of which had never been reported in BNF. The BNF exhibited high antioxidant effects against biologically relevant radicals, and treated animals showed decreased neutrophil influx and NF-kB activation. Thus, these BNF are good sources of antioxidant and anti-inflammatory molecules that can be beneficial for human health as functional foods. Based on their bioactivity, they can be considered as new Brazilian superfruits.Entities:
Keywords: Anti-inflammatory activity; Antioxidant activity; Apigenin-7-O-glucoside (PubChem CID: 45933926); Coumaric acid (PubChem CID: 637542); Cyanidin-3-O-glucoside (PubChem CID: 12303203); Delphinidin 3-O-glucoside (PubChem CID: 443650); Ellagic acid (PubChem CID:5281855); Gallocatechin-gallate (PubChem CID:199472); Lambertianin C (PubChem CID: 101196665).; Naringin hydrate (PubChem CID: 6419948); Native fruits; Phenolic compounds; Quercetin-7-O-glucoside (PubChem CID: 5381351); ROS and RNS; Rutin hydrated (PubChem CID: 45479757)
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Year: 2019 PMID： 30658745 DOI： 10.1016/j.foodchem.2018.12.106
Source DB: PubMed Journal: Food Chem ISSN： 0308-8146 Impact factor: 7.514