Literature DB >> 30658117

Alcohol-related liver disease: Areas of consensus, unmet needs and opportunities for further study.

Mark Thursz1, Patrick S Kamath2, Philippe Mathurin3, Gyongyi Szabo4, Vijay H Shah5.   

Abstract

A joint meeting of the European Association for the Study of the Liver (EASL) and the American Association for the Study of Liver Diseases (AASLD) was held in London on September 30 and October 1, 2017. The goals of the meeting were to identify areas of broad agreement and disagreement, develop consensus, and determine future directions to ultimately reduce the burden, morbidity, and mortality of alcohol-related liver disease (previously termed alcoholic liver disease). The specific aims of the meeting were to identify unmet needs and areas for future investigation, in order to reduce alcohol consumption, develop markers for diagnosis and prognosis of disease, and create a framework to test novel pharmacological agents with pre-specified treatment endpoints.
Copyright © 2019 European Association for the Study of the Liver, American Association for the Study of Liver Diseases. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  ALD; Alcohol; Biomarkers; Clinical trials; Endpoints; Epidemiology; Public health; Unmet needs

Year:  2019        PMID: 30658117     DOI: 10.1016/j.jhep.2018.10.041

Source DB:  PubMed          Journal:  J Hepatol        ISSN: 0168-8278            Impact factor:   25.083


  19 in total

1.  An Open-Label, Dose-Escalation Study to Assess the Safety and Efficacy of IL-22 Agonist F-652 in Patients With Alcohol-associated Hepatitis.

Authors:  Juan P Arab; Tejasav S Sehrawat; Douglas A Simonetto; Vikas K Verma; Dechun Feng; Tom Tang; Kevin Dreyer; Xiaoqiang Yan; William L Daley; Arun Sanyal; Naga Chalasani; Svetlana Radaeva; Liu Yang; Hugo Vargas; Mauricio Ibacache; Bin Gao; Gregory J Gores; Harmeet Malhi; Patrick S Kamath; Vijay H Shah
Journal:  Hepatology       Date:  2020-04-27       Impact factor: 17.425

Review 2.  Treating Alcohol Use Disorder in Chronic Liver Disease.

Authors:  Eric R Yoo; George Cholankeril; Aijaz Ahmed
Journal:  Clin Liver Dis (Hoboken)       Date:  2020-03-26

3.  Alcohol use and binge drinking among U.S. men, pregnant and non-pregnant women ages 18-44: 2002-2017.

Authors:  Deborah S Hasin; Dvora Shmulewitz; Katherine Keyes
Journal:  Drug Alcohol Depend       Date:  2019-09-27       Impact factor: 4.492

4.  Mice lacking α4 nicotinic acetylcholine receptors are protected against alcohol-associated liver injury.

Authors:  Walter H Watson; Jeffrey D Ritzenthaler; Edilson Torres-Gonzalez; Gavin E Arteel; Jesse Roman
Journal:  Alcohol Clin Exp Res       Date:  2022-07-03       Impact factor: 3.928

5.  HealthCall: A randomized trial assessing a smartphone enhancement of brief interventions to reduce heavy drinking in HIV care.

Authors:  Deborah S Hasin; Efrat Aharonovich; Barry S Zingman; Malka Stohl; Claire Walsh; Jennifer C Elliott; David S Fink; Justin Knox; Sean Durant; Raquel Menchaca; Anjali Sharma
Journal:  J Subst Abuse Treat       Date:  2022-01-31

6.  Flightless-I is a potential biomarker for the early detection of alcoholic liver disease.

Authors:  Jaime Arellanes-Robledo; Joseph Ibrahim; Karina Reyes-Gordillo; Ruchi Shah; Leslie Leckey; M Raj Lakshman
Journal:  Biochem Pharmacol       Date:  2020-11-07       Impact factor: 5.858

7.  XIAP Knockdown in Alcohol-Associated Liver Disease Models Exhibits Divergent in vitro and in vivo Phenotypes Owing to a Potential Zonal Inhibitory Role of SMAC.

Authors:  Li He; Tejasav S Sehrawat; Vikas K Verma; Amaia Navarro-Corcuera; Guneet Sidhu; Amy Mauer; Xin Luo; Tomohiro Katsumi; Jingbiao Chen; Soni Shah; Juan Pablo Arab; Sheng Cao; Hamid Kashkar; Gregory J Gores; Harmeet Malhi; Vijay H Shah
Journal:  Front Physiol       Date:  2021-05-07       Impact factor: 4.755

Review 8.  Alcohol-Related Liver Disease: Basic Mechanisms and Clinical Perspectives.

Authors:  Szu-Yi Liu; I-Ting Tsai; Yin-Chou Hsu
Journal:  Int J Mol Sci       Date:  2021-05-13       Impact factor: 5.923

9.  Changes in Serum Myostatin Levels in Alcoholic Hepatitis Correlate with Improvement in MELD.

Authors:  Hani Shamseddeen; Abhishek Madathanapalli; Vijay S Are; Vijay H Shah; Arun J Sanyal; Qing Tang; Tiebing Liang; Kayla Gelow; Teresa A Zimmers; Naga Chalasani; Archita P Desai
Journal:  Dig Dis Sci       Date:  2020-10-19       Impact factor: 3.487

10.  ATF4 activation promotes hepatic mitochondrial dysfunction by repressing NRF1-TFAM signalling in alcoholic steatohepatitis.

Authors:  Liuyi Hao; Wei Zhong; Haibo Dong; Wei Guo; Xinguo Sun; Wenliang Zhang; Ruichao Yue; Tianjiao Li; Alexandra Griffiths; Ali Reza Ahmadi; Zhaoli Sun; Zhenyuan Song; Zhanxiang Zhou
Journal:  Gut       Date:  2020-11-11       Impact factor: 23.059

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