Literature DB >> 30658056

The Elusive Inhibitory Function of the Acidic N-Terminal Segment of the Prodomain of PCSK9: The Plot Thickens.

Nabil G Seidah1.   

Abstract

Entities:  

Year:  2019        PMID： 30658056     DOI： 10.1016/j.jmb.2019.01.015

Source DB:  PubMed          Journal:  J Mol Biol        ISSN： 0022-2836            Impact factor:   5.469


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  5 in total

1.  Ser-Phosphorylation of PCSK9 (Proprotein Convertase Subtilisin-Kexin 9) by Fam20C (Family With Sequence Similarity 20, Member C) Kinase Enhances Its Ability to Degrade the LDLR (Low-Density Lipoprotein Receptor).

Authors:  Ali Ben Djoudi Ouadda; Marie-Soleil Gauthier; Delia Susan-Resiga; Emmanuelle Girard; Rachid Essalmani; Miles Black; Jadwiga Marcinkiewicz; Diane Forget; Josée Hamelin; Alexandra Evagelidis; Kevin Ly; Robert Day; Luc Galarneau; Francois Corbin; Benoit Coulombe; Artuela Çaku; Vincent S Tagliabracci; Nabil G Seidah
Journal:  Arterioscler Thromb Vasc Biol       Date:  2019-09-05       Impact factor: 8.311

Review 2.  The Multifaceted Biology of PCSK9.

Authors:  Nabil G Seidah; Annik Prat
Journal:  Endocr Rev       Date:  2022-05-12       Impact factor: 25.261

3.  Mutational Spectrum of LDLR and PCSK9 Genes Identified in Iranian Patients With Premature Coronary Artery Disease and Familial Hypercholesterolemia.

Authors:  Arman Moradi; Majid Maleki; Zahra Ghaemmaghami; Zahra Khajali; Feridoun Noohi; Maryam Hosseini Moghadam; Samira Kalyinia; Seyed Javad Mowla; Nabil G Seidah; Mahshid Malakootian
Journal:  Front Genet       Date:  2021-02-11       Impact factor: 4.599

4.  Pathogenic gain-of-function mutations in the prodomain and C-terminal domain of PCSK9 inhibit LDL binding.

Authors:  Samantha K Sarkar; Angela Matyas; Ikhuosho Asikhia; Zhenkun Hu; Mia Golder; Kaitlyn Beehler; Tanja Kosenko; Thomas A Lagace
Journal:  Front Physiol       Date:  2022-09-14       Impact factor: 4.755

5.  A transient amphipathic helix in the prodomain of PCSK9 facilitates binding to low-density lipoprotein particles.

Authors:  Samantha K Sarkar; Alexander C Y Foo; Angela Matyas; Ikhuosho Asikhia; Tanja Kosenko; Natalie K Goto; Ariela Vergara-Jaque; Thomas A Lagace
Journal:  J Biol Chem       Date:  2020-01-16       Impact factor: 5.157
  5 in total

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