Andrei Pereira Pernambuco1,2,3, Lucina de Souza Cota Carvalho4,5, Luana Pereira Leite Schetino4,6, Janaíne Cunha Polese7, Renato de Souza Viana8, Débora d' Ávila Reis4. 1. Departamento de Morfologia, Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais (UFMG), Avenida Presidente Antônio Carlos, 6627 - Pampulha, Belo Horizonte, MG, CEP 31270-901, Brazil. pernambucoap@ymail.com. 2. Centro Universitário de Formiga, MG. Avenida Doutor Arnaldo de Senna, 328. Água, Vermelha, Formiga, MG, CEP 35570-000, Brazil. pernambucoap@ymail.com. 3. Universidade de Itaúna, MG. Rodovia MG, 431 Km 45, s/n - Campus Verde, Itaúna, MG, CEP 35680-142, Brazil. pernambucoap@ymail.com. 4. Departamento de Morfologia, Instituto de Ciências Biológicas da Universidade Federal de Minas Gerais (UFMG), Avenida Presidente Antônio Carlos, 6627 - Pampulha, Belo Horizonte, MG, CEP 31270-901, Brazil. 5. Hospital Mater Dei, Avenida do Contorno, 9000 - Barro Preto, Belo Horizonte, MG, CEP 30110-064, Brazil. 6. Universidade Federal do Vale do Jequitinhonha e Mucuri - Campus I. Rua da Glória, n° 187 - Centro, Diamantina, MG, CEP 39100-000, Brazil. 7. Pós-Graduação em Ciências da Reabilitação da Universidade Federal de Minas Gerais, Avenida Presidente Antônio Carlos, 6627 - Pampulha, Belo Horizonte, MG, CEP 31270-901, Brazil. 8. Santa Casa de Caridade de Formiga, MG. Rua Doutor Teixeira Soares, 335 - Centro, Formiga, MG, CEP 35570-000, Brazil.
Abstract
BACKGROUND: Fibromyalgia (FM) is a syndrome characterized by widespread chronic pain associated to other symptoms, such as: fatigue, anxiety, depression and sleep disorders. Health education programs (HEP) have emerged as good non-pharmacological strategies to treat it. However, it is still not clear if the benefits are only subjective, or it has also objective impacts on immune and or neuroendocrine systems. METHODS:Fifty-eight fibromyalgia women were randomly allocated in experimental group (n = 27) or control group (n = 31). The experimental group was submitted to HEP treatment for 11 weeks, while control group did not receive intervention at the same period. All data were collected at zero and 11th week by a blinded researcher. The statistical analysis were made in GraphPad Prism software (version 5.0) with significant level adjusted for α = 0.05. RESULTS:Forty-four patients concluded the full study, 21 in the experimental group and 23 in the control group. Intragroup and intergroup analysis revealed that treatment induced significant increases of IL-4 plasma levels, anti-inflammatory cytokine/inflammatory cytokine ratio (AC/IC ratio), salivary cortisol levels, in addition to significant decreases on FIQ scores. Intergroup variation analyses revealed also significant increases of IL-10 plasma levels. CONCLUSION: The results presented suggest that this kind of HEP could induce subjective and objective changes (immune and neuroendocrine), that could explain, at least in part the improvement of fibromyalgia patient's health status. (Clinical Trial Registration Number - ReBEC - RBR-5tdnbr).
RCT Entities:
BACKGROUND:Fibromyalgia (FM) is a syndrome characterized by widespread chronic pain associated to other symptoms, such as: fatigue, anxiety, depression and sleep disorders. Health education programs (HEP) have emerged as good non-pharmacological strategies to treat it. However, it is still not clear if the benefits are only subjective, or it has also objective impacts on immune and or neuroendocrine systems. METHODS: Fifty-eight fibromyalgiawomen were randomly allocated in experimental group (n = 27) or control group (n = 31). The experimental group was submitted to HEP treatment for 11 weeks, while control group did not receive intervention at the same period. All data were collected at zero and 11th week by a blinded researcher. The statistical analysis were made in GraphPad Prism software (version 5.0) with significant level adjusted for α = 0.05. RESULTS: Forty-four patients concluded the full study, 21 in the experimental group and 23 in the control group. Intragroup and intergroup analysis revealed that treatment induced significant increases of IL-4 plasma levels, anti-inflammatory cytokine/inflammatory cytokine ratio (AC/IC ratio), salivary cortisol levels, in addition to significant decreases on FIQ scores. Intergroup variation analyses revealed also significant increases of IL-10 plasma levels. CONCLUSION: The results presented suggest that this kind of HEP could induce subjective and objective changes (immune and neuroendocrine), that could explain, at least in part the improvement of fibromyalgiapatient's health status. (Clinical Trial Registration Number - ReBEC - RBR-5tdnbr).
Entities:
Keywords:
Cortisol; Cytokines; Fibromyalgia; Health education program; Treatment
Authors: Mateus Dias Antunes; Ana Carolina Basso Schmitt; Amélia Pasqual Marques Journal: Int J Environ Res Public Health Date: 2022-04-27 Impact factor: 4.614
Authors: Edurne Úbeda-D'Ocasar; Victor Jiménez Díaz-Benito; Gracia María Gallego-Sendarrubias; Juan Antonio Valera-Calero; Ángel Vicario-Merino; Juan Pablo Hervás-Pérez Journal: Diagnostics (Basel) Date: 2020-11-09