Zühre Kaya1, Ozgür Umit Akdemir2, Ozlem Lütfiye Atay2, Nalan Akyürek3, Faruk Güçlü Pınarlı4, İdil Yenicesu1, Ülker Koçak1. 1. a Department of Pediatrics, Pediatric Hematology Unit , Gazi University, Faculty of Medicine , Ankara , Turkey. 2. b Departments of Nuclear Medicine , Gazi University, Faculty of Medicine , Ankara , Turkey. 3. c Department of Pathology , Gazi University Faculty of Medicine , Ankara , Turkey. 4. d Department of Pediatric Oncology , Gazi University Faculty of Medicine , Ankara , Turkey.
Abstract
OBJECTIVE: Few data are available on the clinical significance of 18-fluorodeoxyglucose positron emission tomography (FDG-PET/CT) results in patients with leukemia. We investigated the utility of FDG-PET/CT at the time of relapsed/refractory disease in pediatric patients with leukemia. METHODS: Medical records of 28 children with suspected leukemia progression or recurrence during/after chemotherapy or allogeneic stem cell transplantation (allo-SCT) were retrospectively reviewed to determine the utility of FDG-PET/CT. RESULTS: Twenty-two of the 28 patients have documented abnormal imaging findings during clinical follow-up, while six had were interpreted as not demonstrating signal consistent with active leukemia. Of the 22 patients with abnormal FDG-PET/CT studies 14 were found to have FDG-PET/CT reported as consistent with active leukemia and increased leukemia blasts on bone marrow biopsy. Regarding the eight patients without positive FDG-PET/CT and proven leukemia relapse, four had discordant findings on FDG-PET/CT and biopsy, and four had FDG-PET/CT reported as infection. Mean maximum standardized uptake values (SUVmax) were significantly higher among patients whose FDG-PET/CT findings were positive for leukemia as opposed to infectious disease (p < .05). Mean SUVmax was also significantly higher among patients with multifocal lesions on FDG-PET/CT than among those with diffuse lesions (p < .05). CONCLUSIONS: The findings suggest that FDG-PET/CT may be a complementary imaging modality that could be combined with bone marrow examination to improve detection of subtle leukemic infiltration in children with suspected leukemia progression or recurrence after chemotherapy or allo-SCT.
OBJECTIVE: Few data are available on the clinical significance of 18-fluorodeoxyglucose positron emission tomography (FDG-PET/CT) results in patients with leukemia. We investigated the utility of FDG-PET/CT at the time of relapsed/refractory disease in pediatric patients with leukemia. METHODS: Medical records of 28 children with suspected leukemia progression or recurrence during/after chemotherapy or allogeneic stem cell transplantation (allo-SCT) were retrospectively reviewed to determine the utility of FDG-PET/CT. RESULTS: Twenty-two of the 28 patients have documented abnormal imaging findings during clinical follow-up, while six had were interpreted as not demonstrating signal consistent with active leukemia. Of the 22 patients with abnormal FDG-PET/CT studies 14 were found to have FDG-PET/CT reported as consistent with active leukemia and increased leukemia blasts on bone marrow biopsy. Regarding the eight patients without positive FDG-PET/CT and proven leukemia relapse, four had discordant findings on FDG-PET/CT and biopsy, and four had FDG-PET/CT reported as infection. Mean maximum standardized uptake values (SUVmax) were significantly higher among patients whose FDG-PET/CT findings were positive for leukemia as opposed to infectious disease (p < .05). Mean SUVmax was also significantly higher among patients with multifocal lesions on FDG-PET/CT than among those with diffuse lesions (p < .05). CONCLUSIONS: The findings suggest that FDG-PET/CT may be a complementary imaging modality that could be combined with bone marrow examination to improve detection of subtle leukemic infiltration in children with suspected leukemia progression or recurrence after chemotherapy or allo-SCT.
Authors: Austin J Borja; Emily C Hancin; Alexandra D Dreyfuss; Vincent Zhang; Toby Mathew; Chaitanya Rojulpote; Thomas J Werner; Shivaraj Patil; Karthik Gonuguntla; Alexander Lin; Steven J Feigenberg; Samuel Swisher-McClure; Abass Alavi; Mona-Elisabeth Revheim Journal: Am J Nucl Med Mol Imaging Date: 2020-02-25
Authors: Elizabeth M Holland; Bonnie Yates; Alex Ling; Constance M Yuan; Hao-Wei Wang; Maryalice Stetler-Stevenson; Michael LaLoggia; John C Molina; Daniel A Lichtenstein; Daniel W Lee; John A Ligon; Haneen Shalabi; Mark A Ahlman; Nirali N Shah Journal: Blood Adv Date: 2022-04-12