Literature DB >> 30655413

The importance of synthetic chemistry in the pharmaceutical industry.

Kevin R Campos1, Paul J Coleman1, Juan C Alvarez2, Spencer D Dreher2, Robert M Garbaccio2, Nicholas K Terrett2, Richard D Tillyer3, Matthew D Truppo3, Emma R Parmee2.   

Abstract

Innovations in synthetic chemistry have enabled the discovery of many breakthrough therapies that have improved human health over the past century. In the face of increasing challenges in the pharmaceutical sector, continued innovation in chemistry is required to drive the discovery of the next wave of medicines. Novel synthetic methods not only unlock access to previously unattainable chemical matter, but also inspire new concepts as to how we design and build chemical matter. We identify some of the most important recent advances in synthetic chemistry as well as opportunities at the interface with partner disciplines that are poised to transform the practice of drug discovery and development.
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

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Year:  2019        PMID: 30655413     DOI: 10.1126/science.aat0805

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  38 in total

1.  Late-Stage Functionalization of Platensimycin Leading to Multiple Analogues with Improved Antibacterial Activity in Vitro and in Vivo.

Authors:  Youchao Deng; Xiang Weng; Yuling Li; Meng Su; Zhongqing Wen; Xinxin Ji; Nan Ren; Ben Shen; Yanwen Duan; Yong Huang
Journal:  J Med Chem       Date:  2019-07-02       Impact factor: 7.446

2.  Quick Building Blocks (QBB): An Innovative and Efficient Business Model To Speed Medicinal Chemistry Analog Synthesis.

Authors:  Christopher J Helal; Mark Bundesmann; Susan Hammond; Melissa Holmstrom; Jacquelyn Klug-McLeod; Bruce A Lefker; Dale McLeod; Chakrapani Subramanyam; Oleg Zakaryants; Sylvie Sakata
Journal:  ACS Med Chem Lett       Date:  2019-07-05       Impact factor: 4.345

3.  Double-click enables synthesis of chemical libraries for drug discovery.

Authors:  Joseph J Topczewski; En-Chih Liu
Journal:  Nature       Date:  2019-10       Impact factor: 49.962

Review 4.  Technological Innovations in Photochemistry for Organic Synthesis: Flow Chemistry, High-Throughput Experimentation, Scale-up, and Photoelectrochemistry.

Authors:  Laura Buglioni; Fabian Raymenants; Aidan Slattery; Stefan D A Zondag; Timothy Noël
Journal:  Chem Rev       Date:  2021-08-10       Impact factor: 60.622

5.  Investigating 3,3-diaryloxetanes as potential bioisosteres through matched molecular pair analysis.

Authors:  Maryne A J Dubois; Rosemary A Croft; Yujie Ding; Chulho Choi; Dafydd R Owen; James A Bull; James J Mousseau
Journal:  RSC Med Chem       Date:  2021-10-06

Review 6.  Engineering living therapeutics with synthetic biology.

Authors:  Andres Cubillos-Ruiz; Tingxi Guo; Anna Sokolovska; Paul F Miller; James J Collins; Timothy K Lu; Jose M Lora
Journal:  Nat Rev Drug Discov       Date:  2021-10-06       Impact factor: 84.694

7.  A Cascade Reaction of Cinnamyl Azides with Acrylates Directly Generates Tetrahydro-Pyrrolo-Pyrazole Heterocycles.

Authors:  Angela S Carlson; En-Chih Liu; Joseph J Topczewski
Journal:  J Org Chem       Date:  2020-04-20       Impact factor: 4.354

8.  Vicinal, Double C-H Functionalization of Alcohols via an Imidate Radical-Polar Crossover Cascade.

Authors:  Allen F Prusinowski; Raymond K Twumasi; Ethan A Wappes; David A Nagib
Journal:  J Am Chem Soc       Date:  2020-03-06       Impact factor: 15.419

9.  Synthesis of HDAC Inhibitor Libraries via Microscale Workflow.

Authors:  Kevin D Dykstra; Eric Streckfuss; Min Liu; Jian Liu; Younong Yu; Ming Wang; Joseph A Kozlowski; Robert W Myers; Alexei V Buevich; Milana M Maletic; Petr Vachal; Shane W Krska
Journal:  ACS Med Chem Lett       Date:  2021-02-08       Impact factor: 4.345

Review 10.  Synthetic and computational efforts towards the development of peptidomimetics and small-molecule SARS-CoV 3CLpro inhibitors.

Authors:  Abhik Paul; Arnab Sarkar; Sanjukta Saha; Avik Maji; Pritha Janah; Tapan Kumar Maity
Journal:  Bioorg Med Chem       Date:  2021-07-03       Impact factor: 3.641

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