Literature DB >> 30653655

Difficulties and challenges in the development of precision medicine.

Xiaoqin Liu1, Xin Luo2, Chunyang Jiang3, Hui Zhao3.   

Abstract

The rapid development of precision medicine is introducing a new era of significance in medicine. However, attaining precision medicine is an ambitious goal that is bound to encounter some challenges. Here, we have put forward some difficulties or questions that should be addressed by the progress in this field. The proposed issues include the long road to precision medicine for all types of diseases as the unknown domains of the human genome hinder the development of precision medicine. The challenges in the acquisition and analysis of large amounts of omics data, including difficulties in the establishment of a library of biological samples and large-scale data analysis, as well as the challenges of informed consent and medical ethics in precision medicine, must be overcome to attain the goals of precision medicine. To date, precision medicine programs have accomplished many preliminary achievements and will help to drive a dramatic revolution in clinical practices for the medical community. Through these advances, the diagnosis and treatment of many diseases will achieve many breakthroughs. This project is just beginning and requires a great deal of time and money. Precision medicine also requires extensive collaboration. Ultimately, these difficulties can be overcome. We should realize that precision medicine is good for patients, but there is still a long way to go.
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  diagnosis; disease; precision medicine; treatment

Mesh:

Year:  2019        PMID: 30653655     DOI: 10.1111/cge.13511

Source DB:  PubMed          Journal:  Clin Genet        ISSN: 0009-9163            Impact factor:   4.438


  11 in total

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Review 2.  Precision health in Taiwan: A data-driven diagnostic platform for the future of disease prevention.

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3.  Exploring the Interdisciplinary Nature of Precision Medicine:Network Analysis and Visualization.

Authors:  Xin Xu; Jiming Hu; Xiaoguang Lyu; He Huang; Xingyu Cheng
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4.  Opportunity of Next-Generation Sequencing-Based Short Tandem Repeat System for Tumor Source Identification.

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5.  MDN1 Mutation Is Associated With High Tumor Mutation Burden and Unfavorable Prognosis in Breast Cancer.

Authors:  Shuai Hao; Miao Huang; Xiaofan Xu; Xulin Wang; Liqun Huo; Lu Wang; Jun Gu
Journal:  Front Genet       Date:  2022-03-21       Impact factor: 4.599

6.  Experience of patients with lung cancer and with targeted therapy-related skin adverse drug reactions: A qualitative study.

Authors:  Ruofei Du; Huashan Yang; Jizhe Zhu; Huiyue Zhou; Lixia Ma; Mikiyas Amare Getu; Changying Chen; Tao Wang
Journal:  Asia Pac J Oncol Nurs       Date:  2022-07-06

7.  Bending the Curve in Cardiovascular Disease Mortality: Bethesda + 40 and Beyond.

Authors:  David Calvin Goff; Sadiya Sana Khan; Donald Lloyd-Jones; Donna K Arnett; Mercedes R Carnethon; Darwin R Labarthe; Matthew Shane Loop; Russell V Luepker; Michael V McConnell; George A Mensah; Mahasin S Mujahid; Martin Enrique O'Flaherty; Dorairaj Prabhakaran; Véronique Roger; Wayne D Rosamond; Stephen Sidney; Gina S Wei; Janet S Wright
Journal:  Circulation       Date:  2021-02-22       Impact factor: 29.690

8.  Improving Mental Health Services: A 50-Year Journey from Randomized Experiments to Artificial Intelligence and Precision Mental Health.

Authors:  Leonard Bickman
Journal:  Adm Policy Ment Health       Date:  2020-09

9.  miRNA Genetic Variants Alter Their Secondary Structure and Expression in Patients With RASopathies Syndromes.

Authors:  Joseane Biso de Carvalho; Guilherme Loss de Morais; Thays Cristine Dos Santos Vieira; Natana Chaves Rabelo; Juan Clinton Llerena; Sayonara Maria de Carvalho Gonzalez; Ana Tereza Ribeiro de Vasconcelos
Journal:  Front Genet       Date:  2019-11-13       Impact factor: 4.599

Review 10.  Precision Medicine: Steps along the Road to Combat Human Cancer.

Authors:  Samuel F Nassar; Khadir Raddassi; Baljit Ubhi; Joseph Doktorski; Ahmad Abulaban
Journal:  Cells       Date:  2020-09-09       Impact factor: 6.600

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