| Literature DB >> 3065355 |
R Frydman1, H Fernandez, J C Pons, A Ulmann.
Abstract
An antiprogesterone, mifepristone (RU486), was administered to 35 patients undergoing a therapeutic interruption of pregnancy during the second and third trimester for maternal or fetal indications. A randomized double-blind study test was performed using 150 and 450 mg of mifepristone as pretreatment prior to prostaglandins. No toxicity or maternal morbidity were recorded. In three patients the onset of labour occurred spontaneously before prostaglandin administration. Mifepristone produced a modification in the consistency of the cervix with a statistical improvement in cervical calibration in the two groups, but the cervical effect was independent of the dose.Entities:
Keywords: Abortion, Induced; Abortion, Therapeutic; Biology; Cervical Dilatation; Chromosome Abnormalities; Clinical Research; Congenital Abnormalities; Demographic Factors; Developed Countries; Diseases; Endocrine System; Europe; Family Planning; Fertility Control, Postconception; France; Hereditary Diseases; Hiv Infections; Hormone Antagonists; Hormones; Mediterranean Countries; Neonatal Diseases And Abnormalities; Physiology; Population; Population Dynamics; Pregnancy; Pregnancy, Second Trimester; Pregnancy, Third Trimester; Prostaglandins; Reproduction; Research Methodology; Ru-486; Time Factors; Treatment; Viral Diseases; Western Europe
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Year: 1988 PMID： 3065355 DOI： 10.1093/oxfordjournals.humrep.a136786
Source DB: PubMed Journal: Hum Reprod ISSN： 0268-1161 Impact factor: 6.918