Literature DB >> 30652628

Preconditioned or IL4-Secreting Mesenchymal Stem Cells Enhanced Osteogenesis at Different Stages.

Tzuhua Lin1, Yusuke Kohno1, Jhih-Fong Huang1, Monica Romero-Lopez1, Masahiro Maruyama1, Masaya Ueno1, Jukka Pajarinen1, Karthik Nathan1, Zhenyu Yao1, Fan Yang1,2, Joy Y Wu3, Stuart B Goodman1,2.   

Abstract

IMPACT STATEMENT: Pathogen-associated molecular patterns, damage-associated molecular patterns, and other noxious stimuli activate macrophages to induce the proinflammatory responses. Modulation of inflammatory macrophages (M1) into an anti-inflammatory tissue repair macrophage (M2) phenotype at the appropriate time optimizes bone remodeling and regeneration. Simulating the proinflammatory stimuli by using preconditioned mesenchymal stem cells (MSCs) at an earlier stage, and alleviate the inflammation by using IL4-secreting MSCs at a later stage could further optimize bone regeneration in chronic inflammatory conditions, including periprosthetic osteolysis.

Entities:  

Keywords:  IL4; macrophage; mesenchymal stem cells; osteogenesis; preconditioning; wear particles

Mesh：

Substances：

Year:  2019        PMID： 30652628      PMCID： PMC6686696          DOI： 10.1089/ten.TEA.2018.0292

Source DB:  PubMed          Journal:  Tissue Eng Part A        ISSN： 1937-3341            Impact factor:   3.845


  18 in total

Review 1.  The role of macrophages in osteolysis of total joint replacement.

Authors:  Eileen Ingham; John Fisher
Journal:  Biomaterials       Date:  2005-04       Impact factor: 12.479

2.  Establishment of NF-κB sensing and interleukin-4 secreting mesenchymal stromal cells as an "on-demand" drug delivery system to modulate inflammation.

Authors:  Tzuhua Lin; Jukka Pajarinen; Akira Nabeshima; Laura Lu; Karthik Nathan; Zhenyu Yao; Stuart B Goodman
Journal:  Cytotherapy       Date:  2017-07-21       Impact factor: 5.414

3.  Articular chondrocytes and mesenchymal stem cells seeded on biodegradable scaffolds for the repair of cartilage in a rat osteochondral defect model.

Authors:  Rebecca L Dahlin; Lucas A Kinard; Johnny Lam; Clark J Needham; Steven Lu; F Kurtis Kasper; Antonios G Mikos
Journal:  Biomaterials       Date:  2014-06-11       Impact factor: 12.479

4.  NF-κB decoy oligodeoxynucleotide enhanced osteogenesis in mesenchymal stem cells exposed to polyethylene particle.

Authors:  Tzu-Hua Lin; Taishi Sato; Katherine R Barcay; Heather Waters; Florence Loi; Ruth Zhang; Jukka Pajarinen; Kensuke Egashira; Zhenyu Yao; Stuart B Goodman
Journal:  Tissue Eng Part A       Date:  2015-01-22       Impact factor: 3.845

5.  Macrophages promote osteoblastic differentiation in-vivo: implications in fracture repair and bone homeostasis.

Authors:  Linda Vi; Gurpreet S Baht; Heather Whetstone; Adeline Ng; Qingxia Wei; Raymond Poon; Sivakami Mylvaganam; Marc Grynpas; Benjamin A Alman
Journal:  J Bone Miner Res       Date:  2015-06       Impact factor: 6.741

6.  Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production.

Authors:  Krisztián Németh; Asada Leelahavanichkul; Peter S T Yuen; Balázs Mayer; Alissa Parmelee; Kent Doi; Pamela G Robey; Kantima Leelahavanichkul; Beverly H Koller; Jared M Brown; Xuzhen Hu; Ivett Jelinek; Robert A Star; Eva Mezey
Journal:  Nat Med       Date:  2008-11-21       Impact factor: 53.440

7.  Wear particles, periprosthetic osteolysis and the immune system.

Authors:  Stuart B Goodman
Journal:  Biomaterials       Date:  2007-07-23       Impact factor: 12.479

Review 8.  Mesenchymal Stem Cells in Bone Regeneration.

Authors:  M Noelle Knight; Kurt D Hankenson
Journal:  Adv Wound Care (New Rochelle)       Date:  2013-07       Impact factor: 4.730

9.  The effects of immunomodulation by macrophage subsets on osteogenesis in vitro.

Authors:  Florence Loi; Luis A Córdova; Ruth Zhang; Jukka Pajarinen; Tzu-hua Lin; Stuart B Goodman; Zhenyu Yao
Journal:  Stem Cell Res Ther       Date:  2016-01-22       Impact factor: 6.832

10.  Preconditioning of murine mesenchymal stem cells synergistically enhanced immunomodulation and osteogenesis.

Authors:  Tzuhua Lin; Jukka Pajarinen; Akira Nabeshima; Laura Lu; Karthik Nathan; Eemeli Jämsen; Zhenyu Yao; Stuart B Goodman
Journal:  Stem Cell Res Ther       Date:  2017-12-06       Impact factor: 6.832
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  14 in total

1.  Suppression of NF-κB-induced chronic inflammation mitigates inflammatory osteolysis in the murine continuous polyethylene particle infusion model.

Authors:  Takeshi Utsunomiya; Ning Zhang; Tzuhua Lin; Yusuke Kohno; Masaya Ueno; Masahiro Maruyama; Ejun Huang; Claire Rhee; Zhenyu Yao; Stuart B Goodman
Journal:  J Biomed Mater Res A       Date:  2021-03-28       Impact factor: 4.396

2.  Interleukin-4 repairs wear particle induced osteolysis by modulating macrophage polarization and bone turnover.

Authors:  Jukka Pajarinen; Tzuhua Lin; Akira Nabeshima; Taishi Sato; Emmanuel Gibon; Eemeli Jämsen; Tahsin N Khan; Zhenyu Yao; Stuart B Goodman
Journal:  J Biomed Mater Res A       Date:  2020-12-19       Impact factor: 4.396

3.  Bone Immune Response to Materials, Part II: Copper and Polyetheretherketone (PEEK) Compared to Titanium at 10 and 28 Days in Rabbit Tibia.

Authors:  Ricardo Trindade; Tomas Albrektsson; Silvia Galli; Zdenka Prgomet; Pentti Tengvall; Ann Wennerberg
Journal:  J Clin Med       Date:  2019-06-07       Impact factor: 4.241

Review 4.  Periprosthetic Osteolysis: Mechanisms, Prevention and Treatment.

Authors:  Stuart B Goodman; Jiri Gallo
Journal:  J Clin Med       Date:  2019-12-01       Impact factor: 4.241

Review 5.  Modeling Complex Orthopedic Trauma in Rodents: Bone, Muscle and Nerve Injury and Healing.

Authors:  Huaishuang Shen; Aysha M Gardner; Juhee Vyas; Ryosuke Ishida; Vivianne L Tawfik
Journal:  Front Pharmacol       Date:  2021-02-01       Impact factor: 5.810

6.  Different Effects of Intramedullary Injection of Mesenchymal Stem Cells During the Acute vs. Chronic Inflammatory Phase on Bone Healing in the Murine Continuous Polyethylene Particle Infusion Model.

Authors:  Takeshi Utsunomiya; Ning Zhang; Tzuhua Lin; Yusuke Kohno; Masaya Ueno; Masahiro Maruyama; Claire Rhee; Ejun Huang; Zhenyu Yao; Stuart B Goodman
Journal:  Front Cell Dev Biol       Date:  2021-03-19

7.  Feline adipose tissue-derived mesenchymal stem cells pretreated with IFN-γ enhance immunomodulatory effects through the PGE₂ pathway.

Authors:  Seol Gi Park; Ju Hyun An; Qiang Li; Hyung Kyu Chae; Su Min Park; Jeong Hwa Lee; Jin Ok Ahn; Woo Jin Song; Hwa Young Youn
Journal:  J Vet Sci       Date:  2021-03       Impact factor: 1.672

Review 8.  The Crosstalk between Mesenchymal Stem Cells and Macrophages in Bone Regeneration: A Systematic Review.

Authors:  Rita Lih-Ying Shin; Chien-Wei Lee; Oscar Yuan-Jie Shen; Hongtao Xu; Oscar Kuang-Sheng Lee
Journal:  Stem Cells Int       Date:  2021-06-14       Impact factor: 5.443

9.  The efficacy of lapine preconditioned or genetically modified IL4 over-expressing bone marrow-derived mesenchymal stromal cells in corticosteroid-associated osteonecrosis of the femoral head in rabbits.

Authors:  Masahiro Maruyama; Seyedsina Moeinzadeh; Roberto Alfonso Guzman; Ning Zhang; Hunter W Storaci; Takeshi Utsunomiya; Elaine Lui; Elijah Ejun Huang; Claire Rhee; Qi Gao; Zhenyu Yao; Michiaki Takagi; Yunzhi Peter Yang; Stuart B Goodman
Journal:  Biomaterials       Date:  2021-06-21       Impact factor: 15.304

Review 10.  Modulation of the Inflammatory Response and Bone Healing.

Authors:  Masahiro Maruyama; Claire Rhee; Takeshi Utsunomiya; Ning Zhang; Masaya Ueno; Zhenyu Yao; Stuart B Goodman
Journal:  Front Endocrinol (Lausanne)       Date:  2020-06-11       Impact factor: 5.555
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