Long-term graft patency after coronary artery bypass grafting: Effects of surgical technique.

The aim of the current study was to identify surgical factors associated with long-term patency of grafts used in coronary artery bypass grafting (CABG). The present study analyzed data from 127 patients who underwent CABG at our institute between 2000 and 2006 and presented for ambulatory examination and coronary computed tomography angiography evaluation of graft patency in 2016 (139.78±36.64 months post-CABG). The 127 patients received 340 grafts (2.68 grafts/patient) and 399 distal anastomoses (3.14 anastomoses/patient), 220 (55.14%) with arterial grafts and 179 (44.86%) with saphenous vein grafts. Graft patency varied according to coronary territory, proximal anastomosis type (in situ graft, composite graft, graft anastomosed to the ascending aorta), Y anastomosis angle (47.21° for patent arterial grafts vs. 56° for occluded), and distal anastomosis angle (in sequential anastomoses irrespective to graft type, 48.60° for patent side-to-side anastomosis vs. 53.97° for occluded, 65.12° for patent end-to-side anastomosis vs. 90.80° for occluded; in single end-to-side anastomosis of arterial grafts, 39.46° for patent and 44.94° for occluded). A single end-to-side anastomosis angle 60° or greater was associated with a 5.149 occlusion odds ratio (OR) (P<0.001) for arterial grafts. Venous grafts were not sensitive to single end-to-side anastomosis angle. In conclusion, a small anastomosis angle for proximal Y and distal anastomoses is associated with a higher long-term patency of the free graft. Radial artery grafts registered higher patency rates when anastomosed to the ascending aorta compared with composite grafting with the left internal thoracic artery, whereas in situ right internal thoracic artery (RITA) anastomosed to the right coronary territory is associated with a lower patency rate compared with free RITA used to revascularise the anterolateral or circumflex territory in composite grafting.

Introduction

In the present, cardiovascular diseases are the leading cause of death worldwide, with an estimated 17,7 million deaths per year of which 7.4 million are attributed to coronary artery disease (CAD) alone (1). Between 18 and 91 per 100,000 inhabitants benefit from coronary artery bypass grafting (CABG) in Europe (2) and, according to both European (3) and American (4) Societies' guidelines, CABG is associated with an increase in quality of life and survival in patients with unprotected left main (or equivalent) and multi-vessel disease; however, the ideal grafting technique has not been established.

Early CABG interventions were performed almost entirely using saphenous vein grafts (SVG) with a late attrition rate of 2–5% per year after surgery related to the intrinsic pathologic changes (5). Compared with veins, internal thoracic arteries (ITA) have an extremely low attrition rate with very good long-term patency rates (96.4% over 15 years) (6). The use of an ITA graft results in a mean survival of 4.4 years longer than CABG with veins alone over a 20-year follow-up period (7), and bilateral ITA [left internal thoracic artery (LITA) and right internal thoracic artery (RITA)] use offers even better survival rates than single ITA grafts (8).

Most patients with CAD have a multi-vessel disease and require revascularisation of more than two coronary arteries. The pursuit of additional grafts and anastomosis techniques to achieve complete revascularisation (5–6 distal anastomoses) has not proved to be an easy task (9,10). One option is the radial artery (RA), which supplies a long graft with a calibre superior to ITA but is prone to spasm and intimal hyperplasia in case of inadequate harvesting and preparation due to its muscular structure, leading to its abandonment in the early years of CABG (11). Improved harvesting and preparation finally made RA a viable option as a graft superior to SVG in terms of long-term patency (91.8% vs. 86.4%) (12,13). Various teams have proposed alternative grafts (right gastroepiploic artery, inferior epigastric artery, splenic artery, ulnar artery, subcapsular artery, left gastric artery and lateral circumflex femoral artery), but their long-term reliability has not yet been confirmed (14).

Complete revascularisation usually has to be accomplished using two to three grafts with the best-proven patency rates. In these circumstances, sequential, composite, Y-grafts, T-grafts, and combinations are required to bypass all stenosis/occlusions with a limited number of grafts. Buxton described several graft configurations to be used (15) in total arterial revascularisation, but safety, efficacy, and long-term patency have not been assessed for the majority of these configurations (16–18).

The purpose of the current study was to identify surgical factors associated with long-term graft patency.

Patients and methods

Patient population, surgical technique, and postoperative treatment

Demographic, clinical, echocardiographic, and angiographic data on patients undergoing CABG at the Cardiovascular Diseases Institute in Iasi, Romania, have been retrospectively collected and introduced into a database since 2000 together with intraoperative parameters (extracorporeal circulation type and time, aortic cross clamp time, CABG technique, number and type of grafts, associated procedures) and postoperative data (intensive care unit parameters, complications, and within 30 days mortality). The CABG technique varied according to the international trend at the time of surgery from total venous to total arterial revascularisation and from one graft-one anastomosis to composite and sequential grafting. All interventions were performed by the same experienced primary surgeon (>7,000 cardiac surgery interventions performed) using cardiopulmonary bypass (CPB) and continuous sutures with Prolene 8-0 for graft anastomosis. No intraoperative flow measurements were performed.

Long-term postoperative treatment consisted of beta blockers, statins, and enteric-coated aspirin in all cases. Patients who benefited from a RA graft received a calcium channel blocker (Amlodipine) for the first 3 months to prevent spasm. Treatment was adjusted according to the blood pressure, left ventricular ejection fraction (LVEF), and comorbidities.

Patient follow-up

In 2016, the status of all 394 patients who received surgery between 2000 and 2006 and were discharged from the hospital was verified through the National Health Insurance House database, and there were 269 identified survivors (68.27%). All survivors were recalled for an ambulatory examination and coronary computed tomography angiography (CCTA) evaluation of graft patency by invitation letter submitted to the last known address or by telephonic contact. A total of 159 patients responded, and the CCTA assessment of graft patency (interpretable images) was performed in 127 patients who had received surgery over 10 years earlier and who consented to and presented no contraindications for the examination. The 127 patients were evaluated after a mean postoperative interval of 139.78±36.64 months and represented the study group of the current article. No redo CABG or percutaneous transluminal coronary angioplasty (PTCA) after CABG were performed in the current study group.

CCTA evaluation

All CCTA evaluations were performed using a 2nd generation 2*128-slices dual source multi-detector CT (MDCT) scanner (Siemens Somatom Definition Flash; Siemens Healthineers, Erlangen, Germany). Optimal reconstructions at different percentage times of an R-R interval were performed (0.75 mm slice thickness) and submitted to the Syngo.via workstation (Siemens Healthineers) for image analysis (graft type and status, type of proximal and distal anastomosis, anastomosis angle).

Image analysis

All CT examinations were evaluated twice by the same radiologist for the following parameters: graft type and status (confronted with the operative protocol), proximal and distal anastomosis type (confronted with the operative protocol), anastomosis angle (Y anastomosis angle measured between the branches of the Y, distal end-to-side and side-to-side anastomosis angle measured between the native vessel and the graft) (Fig. 1). All angles were measured on multiplanar reconstructions (MPR) with the two vessels (graft and native coronary artery) in the same plane.

Figure 1.

Measurement of (A) distal side-to-side, (B) distal end-to-side and (C) Y anastomosis angle on computerised tomography images.

Statistical analysis

Continuous variables are expressed as mean ± standard deviation (SD) and categorical variables as percentages. Groups were compared using the chi-square test for categorical variables, and the Student t test and Wilcoxon-Mann-Whitney U test for continuous variables on the basis of their distribution. Normality was verified using the Kolmogorov-Smirnov and the Shapiro-Wilk W tests. Logistic regression was employed for testing the association between categorical and continuous variables previously identified as affecting the outcome (graft patency) at univariable analysis with P<0.05. A receiver operating characteristic (ROC) curve was used for identifying discrimination threshold (cut-off) value for continuous variables. Statistical analyses were performed using SPSS Statistics 24 for Mac OS X (IBM, Corp., Armonk, NY, USA).

The study was approved by the Ethics Committee of the ‘Grigore T. Popa’ University of Medicine and Pharmacy (Iasi, Romania) and by the Ethics Committee of the ‘Prof. Dr. George I.M. Georgescu’ Cardiovascular Diseases Institute (Iasi, Romania).

Results

Baseline characteristics

The preoperative, operative, and postoperative data of the 127 patients are summarised in Tables I–III.

Table I.

Preoperative data.

Parameter	Value (127 patients)	Percentage (%)
Mean age (years) ± SD	67.54±8.84	–
≤65 years	44	34.65
>65 years	83	65.35
Sex, female	19	14.96
Family history	41	32.28
Smoking	49	38.58
Diabetes mellitus	28	22.05
Dyslipidaemia	97	76.38
MAD	19	14.96
AHT	77	60.63
COPD	8	6.30
NYHA II heart failure	18	14.17
NYHA III–IV heart failure	24	18.90
Prior AMI	65	51.18
Arrhythmias	23	18.11
Mean LVEF (%)	53.81±10.77	–
Number of affected coronary arteries	2.86±1.24	–
Diffuse disease	29	22.83
Three vessel disease	71	55.91

SD, standard deviation; MAD, multisite artery disease; AHT, arterial hypertension; COPD, chronic obstructive pulmonary disease; NYHA, New York Heart Association; AMI, acute myocardial infarction; LVEF, left ventricular ejection fraction.

Table III.

Postoperative data (initial 30 days).

Parameter	Value (127 patients)	Percentage
Reintervention for haemorrhage or sternal dehiscence	10	7.87
Acute renal failure	2	1.57
Arrhythmia	31	24.41
Neurological complications	2	1.57
Deep sternal wound infection	2	1.57
Other infections (urinary tract, pneumonia)	3	2.36
Digestive complications	4	3.15
(ileus, Clostridium difficile infection)

Graft patency assessment

The 127 patients presented a total number of 340 grafts (2.68 grafts/patient) and 399 distal anastomoses (3.14 anastomoses/patient), 220 (55.14%) performed using arterial grafts (122 LITA, 53 RA, 45 RITA) and 179 (44.86%) using SVG. Overall graft patency at 10 to 16 years after the surgical intervention was of 90.16% for LITA (12 occluded grafts), 75.55% for RITA (11 occluded grafts), 79.25% for RA (11 occluded grafts), and 74.3% for SVG (46 occluded grafts) with variations according to coronary territory (Table IV).

Table IV.

Graft patency according to coronary territory.

Variable	Right coronary territory (%)	Circumflex artery territory (%)	Anterolateral territory (%)
Right internal thoracic	3 occluded grafts out of	7 occluded grafts out of 23 (30.43)	1 occluded graft out of
artery graft	8 (37.5)		14 (7.14)
Radial artery graft	6 occluded grafts out of	4 occluded grafts out of 16 (25)	1 occluded graft out of
	31 (19.35)		6 (16.67)
Saphenous vein graft	24 occluded grafts out of	11 occluded grafts out of 63 (17.46)	11 occluded graft out of
	68 (35.29)		48 (22.92)

The effect of proximal anastomosis type

In case of RITA and RA, the authors analysed graft patency according to proximal anastomosis type (in situ graft, composite graft with Y/T anastomosis, and graft anastomosed to the ascending aorta). All saphenous vein grafts were anastomosed proximally to the ascending aorta, and LITA was used in situ in all cases except one so both grafts were excluded from this analysis.

RITA was used in situ in 8 cases (17.78%), as a composite graft anastomosed Y/T to LITA in 36 cases (80%), and as a free graft anastomosed to the ascending aorta in 1 case (2.22%). The occlusion rate was of 3/8 (37.5%) for in situ RITA and 8/3936 (22.22%) for composite grafting. The free graft anastomosed to the ascending aorta was patent. Chi-square test showed no association of RITA patency with proximal anastomosis type (P=0.501).

RA was used as a free graft anastomosed to the ascending aorta in 40 cases (75.47%) with an occlusion rate of 6/40 (15%) and as a composite graft anastomosed Y/T to LITA in 13 cases (25.43%) with an occlusion rate of 5/13 (38.46%). The Pearson chi-square test proved a significant association of graft patency with proximal anastomosis type (χ2=10.932, P=0.001) (Table V). Logistic regression showed a 0.110 OR (P=0.002) for RA anastomosed to the ascending aorta, thus certifying a protective effect against graft failure (Table VI).

Table V.

Association of RA graft patency with proximal anastomosis type.

Variable	Occluded (%)	Patent (%)	Pearson chi-square	P-value
RA-Aorta	6 (15)	34 (85)	10.932	0.001
RA-LITA	5 (38.46)	8 (61.54)

RA, radial artery; LITA, left internal thoracic artery.

Table VI.

Prognostic value of the proximal anastomosis type (RA-aorta).

						95% CI for EXP(B)
B	SE	Wald	df	Sig.	Exp(B)	Lower	Upper
Proximal anastomosis
−2.205	0.722	9.327	1	0.002	0.110	0.027	0.454
Constant
0.470	0.570	0.680	1	0.410	1.600

RA, radial artery; B, unstandardized regression weight; SE, standard error; Wald, Wald chi-square test; Df, degrees of freedom; Sig., significance level; Exp(B), exponentiation of the B coefficient; CI, confidence interval.

The effect of Y/T anastomosis angle

The mean angle for Y/T anastomoses with both grafts patent was 47.21° compared with 56° for anastomoses with occlusion of the free arterial graft (RA or RITA). The Wilcoxon-Mann-Whitney U test identified a significant difference between the anastomosis angle of patent vs. occluded grafts (P=0.015), a smaller angle being registered in case of patent anastomosis (Table VII) (Fig. 2). The authors did not identify a high sensitivity and specificity threshold angle with prognostic value in affirming the risk of occlusion for Y-anastomoses.

Table VII.

Proximal and distal anastomosis angle comparison between occluded and patent grafts.

Variable	Occluded	Patent	P-value
Y/T anastomosis angle	56±27.22°	47.21±25.05°	0.015
Side-to-side anastomosis (sequential grafting)	53.97±23.54°	48.60±21.14°	0.005
End-to-side anastomosis (sequential grafting)	90.80±11.27°	65.12±26.04°	0.002
End-to-side (single distal anastomosis)	44.94±19.38°	39.46±18.71°	0.034

Figure 2.

Coronary computed tomography angiography reconstruction demonstrating a proximal Y anastomosis of the right internal thoracic artery with the left internal thoracic artery. The left internal thoracic artery was used in situ and the right internal thoracic artery as a free graft with sequential distal anastomoses to CX territory.

The effect of distal anastomosis type and angle

In case of distal anastomosis, 31 were side-to-side performed with 27 sequential grafts, the rest of 368 being end-to-side (Fig. 3). Of the 27 sequential grafts, 9 were venous (occlusion of 2 end-to-side anastomoses and 0/11 side-to-side anastomoses) and 18 arterial (occlusion of 7 end-to-side anastomoses and 9/20 side-to-side anastomoses). The small number of cases did not allow statistical interpretation, but one can note a higher patency rate of venous grafts with sequential anastomoses.

Figure 3.

saphenous vein graft with two side-to-side anastomoses used to revascularise CX territory.

Concerning the anastomosis angle in sequential grafting, the angle was of 48.60° for patent side-to-side anastomoses compared with 53.97° for occluded ones. Similarly, the anastomosis angle was smaller for patent end-to-side anastomoses (65.12°) compared with occluded ones (90.80°) (P=0.002) (Table VII). The analysis was performed irrespective to graft type.

In case of single distal anastomosis (end-to-side), arterial grafts proved to be sensitive to the anastomosis angle with a mean value of 39.46°±21.97° for patent grafts and 44.94°±29.52° for occluded ones (P=0.034) (Table VII). For venous grafts, the difference was not statistically significant. Using the area under the curve (AUC) of ROC, an angle of 60° was determined as a threshold value with an 80% sensitivity and specificity in affirming arterial graft occlusion (Fig. 4). Logistic regression identified an occlusion OR of 5.149 for arterial grafts in case of distal anastomosis angle of 60° or greater (P<0.001) (Table VIII).

Figure 4.

ROC curve fr identifying the cut-off value of the distal anastomosis angle. ROC, receiver operating characteristic.

Table VIII.

Prognostic value of a distal anastomosis angle ≥60°.

						95% CI for EXP(B)
B	SE	Wald	Df	Sig.	Exp(B)	Lower	Upper	Occluded anastomoses
Angle
1.639	0.444	13.630	1	<0.01	5.149	2.157	12.292	14 (8.38%) for <60°
Constant
−2.367	0.302	61.476	1	<0.01	0.094			6 (17.14%) for ≥60°

B, unstandardized regression weight; SE, standard error; Wald, Wald chi-square test; Df, degrees of freedom; Sig., significance level; Exp(B), exponentiation of the B coefficient; CI, confidence interval.

Discussion

Over the decades, graft patency has been assessed for individual grafts alone and not for CABG as an entity per se, while the dilemma of designing an optimal grafting technique bringing considerable haemodynamic improvement and graft patency remained unsolved despite the increase in worldwide research. A literature review allowed us to classify factors influencing graft patency into morphological (vessel type, graft length, and calibre) (11,15), pathophysiological (competitive flow through the native coronary artery, graft degenerative changes) (15), and surgical (technical expertise, graft harvesting and preparation, grafting design, and anastomosis technique) categories (16,17). This single-centre study analysed graft patency according to surgical technique, namely proximal and distal anastomosis type and angle.

Proximal anastomosis

We found a higher patency rate for RITA used as a composite graft for the anterolateral or CX territory (78.38%) compared with in situ RITA graft for the RCA territory (62.5%) and for RA anastomosed to the ascending aorta (85%) compared with composite grafting with LITA (61.54%).

A number of studies (18–22) analysed the patency of in situ and free pedicled ITAs. Dion et al prefer an in situ pedicled ITA each time the local anatomy, the topography, and number of lesions allow it, the physiological response being predictable in terms of flow and calibre according to their study (23). They evaluated ITA grafts irrespective of type and target coronary territory at 7.5 years from surgery and found a patency rate of 96.3% for in situ ITAs compared with 86.5% for free grafts anastomosed to the ascending aorta or used for Y/T anastomosis.

Fukui, Calafiore, and Tatoulis consider, based on angiographic results obtained at 12 months, 17.5 months, and 41,5 months postoperatively, that there are no differences in patency rates and prognosis between free ITAs with composite anastomosis and in situ ITAs on one hand and between pedicled and skeletonised grafts on the other hand (19–21). In our study, in situ RITA was used exclusively for the RCA territory and free ITAs as composite grafts for the anterolateral or CX territory, thus introducing another variable in the equation, the coronary territory. In 2012, Mukherjee et al performed a meta-analysis on 226 articles to compare the outcome of RITA and SVG used to revascularise the right coronary territory and concluded that SVG may offer a superior patency rates when used to revascularise RCA compared with RITA (23). The poor outcome of RITA grafted to the right coronary territory could be explained by graft stretching in cases of left ventricular dilation, different haemodynamic conditions, and runoff.

In our group, RA was used as a free graft with a higher patency rate when anastomosed to the ascending aorta vs. composite grafting. Similar results were previously reported in 2009 by Jung et al, who analysed 893 patients that benefited from RA grafts, 451 with direct RA to aortic anastomosis (group I) and 422 with RA composite grafting with the LITA (group II). The patency rate was significantly higher in group I than in group II in the early postoperative period (98.3% vs. 94.5%), at 1 year (93.8 vs. 90.5%), 2 years (90.5% vs. 85.3%), and 5 years (74.3% vs. 65.2%). Jung et al attribute the difference to a higher drive pressure and flow afforded by the direct aortic connection, thus preventing occlusion (24).

In case of composite grafting, the long-term patency was conditioned by the anastomosis angle, with smaller values in cases of patent free graft (47.21°) compared with occluded free graft (56°). No in vivo study analysing Y anastomosis angle was identified in the literature. Experimental research performed by Song et al using three-dimensional simulation of a Y anastomosis by computational fluid dynamics support our results by demonstrating that the more acute is the angle of anastomosis, the smaller are the energy loss and the back flow into the graft (25).

Distal anastomosis

Compared to venous grafts, arterial grafts also proved sensitive to distal anastomosis angle, with a mean value of 39.46° for patent grafts vs. 44.94° for occluded ones and a 5.149 occlusion OR in cases of distal anastomosis angle 60° or greater for grafts with single end-to-side anastomosis. The first efforts to imagine an optimal distal anastomosis technique aimed to improve local haemodynamics by changing the anastomosis geometry, as tissue remodelling is influenced by the end-to-side anastomosis angle, a factor conditioning flow fields and wall shear stress (WSS) (26). Staalsen et al demonstrated using polyurethane grafts that no flow disturbances were detected at the toe and one diameter downstream with an anastomosis angle of 15°, and a zone of recirculation extending from the toe to one diameter downstream was identified in the 45° and 90° anastomoses. An anastomosis angle of 30° is generally associated with a uniform flow and a smooth transition between graft flow and target vessel flow (26).

Similar results were obtained for sequential anastomosis, with an angle of 48.60° for patent side-to-side anastomoses compared with 53.97° for occluded and 65.12° for patent end-to-side anastomoses vs. 90.80° for occluded irrespective of graft type. One can notice wider anastomoses angles for distal end-to-side anastomoses of sequential grafts compared with grafts with single distal anastomosis. The final anastomosis of side-to-side grafts is usually performed with posterolateral arteries on the diaphragmatic surface of the heart or with the posterior descending artery, thus explaining a wider angle compared with grafts with single distal anastomosis performed with diagonal or marginal arteries. In cases of sequential anastomoses, Frauenfelder et al (27) and Fei et al (28) demonstrated that wider anastomotic angles generate higher WSS values and flow oscillation around the toe and along the bed of the target vessel. These studies consider the graft and target vessel as forming a planar configuration, which is far from reality, but similar results were obtained by Sherwin et al (29), who investigated the influence of out-of-plane geometry and found that the anastomosis bed was most affected by flow oscillation generated by wider anastomoses angles yielding to intimal hyperplasia and long-term occlusion.

Bonert et al (30) compared the patency of side-to-side with end-to-side anastomoses and concluded that the parallel form of side-to-side anastomosis contributes to maintaining graft patency in side-to-side anastomoses by diminishing the haemodynamic risk and spatial gradients. In cases of end-to-side anastomosis, the haemodynamic forces act perpendicular to the target vessel wall and trigger important variations of WSS (1.5 Pa) and formation of stagnation and flow separation zones (29). In our study, the limited number of sequential anastomoses did not allow a statistically significant comparison of side-to-side to end-to-side anastomoses, but venous grafts proved to have a higher patency with side-to-side anastomoses compared with arterial ones.

Although limited by the small sample and reduced number of cases for each graft configuration, our study is the first to quantify potential factors conditioning graft patency on CCTA images, as there is a paucity of in vivo studies examining morphological, pathophysiological, and surgical factors that influence long-term graft patency. Morphological factors (e.g., graft length, target vessel calibre, graft-to-host diameter ratio, degree of stenosis) were analysed together with surgical factors and will be the subject of a different article. Currently, the majority of the research in the field is carried on in in vitro or computerised models that cannot take into account all possible graft configurations. Tremblay et al (31) performed the only study up to date that uses CCTA to identify morphological and morphometrical factors associated with a saphenous vein bridge (SVB) dysfunction. They analysed SVB length, SVB segment lengths, SVB lumen sectional areas, anastomostic angulations and intrinsic SVB angulations on a group of 40 patients and concluded that CT could be used to identify quantitative graft parameters associated with graft dysfunction. Our study extends this idea and identifies morphological and morphometrical factors associated with long-term graft patency according to graft type, grafted territory, anastomosis type and angle; factors that could lead to adjustment of the surgical technique to increase long-term patency rates and reduce the risk of major adverse cardiac events. Bias was controlled as much as possible by analysing data according to the aforementioned factors, all cases being operated by the same surgical team. The current research is to be considered a pilot study and will be further extended by systematic recall of patients who received surgery more than 10 years ago for a specific analysis focused on target vessels, especially the RCA.

In conclusion, surgical technique is an important factor conditioning long-term graft patency. A small anastomosis angle, both for proximal Y and distal anastomoses, is associated to a higher long-term patency of the free graft. RA grafts registered higher patency rates when anastomosed to the ascending aorta compared with composite grafting with LITA, whereas in situ RITA anastomosed to the right coronary territory is associated with a lower patency rate compared with free RITA used to revascularise the anterolateral or CX territory as part of composite grafting.

Table II.

Surgical data.

Parameter	Value (127 patients)	Percentage (%)
Emergency surgery	3	2.36
Associated interventions	13	10.24
ACC time (min) ± SD	90.01±61.35
ECC time (min) ± SD	136.82±64.13
Mean number of grafts/patient	2.68±0.94
Mean number of arterial grafts/patient	1.64±1.20
Mean number of venous grafts/patient	1.52±0.79
Mean number of distal anastomoses/patient	3.14±1
Conventional CABG (at least 1 SVG)	79	62.20
TAR	38	29.92
Single graft	5	3.94
Total venous	5	3.94
IABP usage	1	0.79
Complete revascularisation	102	80.31

Associated interventions: Valve surgery, atrial fibrillation ablation, ascending aorta replacement, left ventricular aneurysm repair. SD, standard deviation; ACC, aortic cross clamp; ECC, extracorporeal circulation; CABG, coronary artery bypass grafting; TAR, total arterial revascularisation; IABP, intra-aortic balloon pump.