Lanting Xu1,2, Meimei Xing1,2, Xiaoqing Xu2, Fatma Sa Saadeldeen2, Zhenhua Liu1,2, Jinfeng Wei1,2, Wenyi Kang1,2. 1. National Center for Research & Development of Edible Fungus Processing Technology, Henan University, Kaifeng 475004, China. 2. Joint International Research Laboratory of Food & Medicine Resource Function, Henan Province, Kaifeng 475004, China.
Abstract
AIM: Alizarin (AZ), that can be isolated from Rubia cordifolia, has biological activities such as antioxidation and anti-inflammatory. This study aimed to investigate the effect of AZ on glucose and lipid metabolism disorders in alloxan-induced diabetic mice and also explored the effect of AZ on insulin resistance in 3T3-L1 adipocytes. RESULTS: The research showed that AZ could decrease fasting and postprandial blood glucose, TG, TC and MDA, and it could also increase liver glycogen levels and SOD activity in diabetic mice. AZ could significantly improve the glucose uptake of 3T3-L1 adipocytes under insulin resistance, and could also increase GLUT4 protein expression levels, IRS-1 and Akt protein phosphorylation. CONCLUSION: These results showed that AZ has the potential to reduce blood sugar and improve insulin resistance.
AIM: Alizarin (AZ), that can be isolated from Rubia cordifolia, has biological activities such as antioxidation and anti-inflammatory. This study aimed to investigate the effect of AZ on glucose and lipid metabolism disorders in alloxan-induced diabeticmice and also explored the effect of AZ on insulin resistance in 3T3-L1 adipocytes. RESULTS: The research showed that AZ could decrease fasting and postprandial blood glucose, TG, TC and MDA, and it could also increase liver glycogen levels and SOD activity in diabeticmice. AZ could significantly improve the glucose uptake of 3T3-L1 adipocytes under insulin resistance, and could also increase GLUT4 protein expression levels, IRS-1 and Akt protein phosphorylation. CONCLUSION: These results showed that AZ has the potential to reduce blood sugar and improve insulin resistance.