María Isabel Peña-Cano1, Renata Saucedo2, Enrique Morales-Avila1, Jorge Valencia3, Jose A Zavala-Moha4, Adriana López5. 1. Faculty of Chemistry, Universidad Autonoma del Estado de Mexico, Toluca, Mexico. 2. Endocrine Research Unit, National Medical Center, Instituto Mexicano del Seguro Social, Mexico City, Mexico, sgrenata@yahoo.com. 3. Endocrine Research Unit, National Medical Center, Instituto Mexicano del Seguro Social, Mexico City, Mexico. 4. Oncology Department of Regional Hospital 251, Instituto Mexicano del Seguro Social, Mexico City, Mexico. 5. Pathology Department of Regional Hospital 251, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
Abstract
BACKGROUND: Obesity is a risk factor for breast cancer (BC). Some mechanisms through which obesity can lead to cancer development are insulin-like growth factors (IGFs), adipokines, and microRNAs (miRs). The objective of the study was to determine whether miR-17-5p, miR-195-5p, and miR-221-3p expressions were deregulated in serum samples of obese and nonobese postmenopausal women with BC. In addition, insulin, adiponectin, leptin and IGFs were analyzed. METHODS: Fifty postmenopausal women with newly diagnosed BC and 50 postmenopausal healthy women were evaluated. Differences in miRs between BC and healthy cases and between obese and lean participants were analyzed. Receiver operating characteristic curves for miRs for discriminating patients with or without BC were established, and relationships between the miRs, adipokines, and breast tumor characteristics were also investigated. RESULTS: miR-17-5p and miR-195-5p were higher in patients with BC in comparison to the controls, while miR-221-3p and adiponectin were significantly lower. Increased levels of miR-195-5p allowed the differentiation of BC from controls with a sensitivity of 83.3 and a specificity of 78.3%, and were associated with lobular and poorly differentiated cancer. There was no difference in miRs levels between obese and lean groups. CONCLUSIONS: Circulating miRs and adiponectin were deregulated in postmenopausal women with BC.
BACKGROUND:Obesity is a risk factor for breast cancer (BC). Some mechanisms through which obesity can lead to cancer development are insulin-like growth factors (IGFs), adipokines, and microRNAs (miRs). The objective of the study was to determine whether miR-17-5p, miR-195-5p, and miR-221-3p expressions were deregulated in serum samples of obese and nonobese postmenopausal women with BC. In addition, insulin, adiponectin, leptin and IGFs were analyzed. METHODS: Fifty postmenopausal women with newly diagnosed BC and 50 postmenopausal healthy women were evaluated. Differences in miRs between BC and healthy cases and between obese and lean participants were analyzed. Receiver operating characteristic curves for miRs for discriminating patients with or without BC were established, and relationships between the miRs, adipokines, and breast tumor characteristics were also investigated. RESULTS:miR-17-5p and miR-195-5p were higher in patients with BC in comparison to the controls, while miR-221-3p and adiponectin were significantly lower. Increased levels of miR-195-5p allowed the differentiation of BC from controls with a sensitivity of 83.3 and a specificity of 78.3%, and were associated with lobular and poorly differentiated cancer. There was no difference in miRs levels between obese and lean groups. CONCLUSIONS: Circulating miRs and adiponectin were deregulated in postmenopausal women with BC.
Authors: Thu H N Nguyen; Thanh T N Nguyen; Tran T M Nguyen; Le H M Nguyen; Luan H Huynh; Hoang N Phan; Hue T Nguyen Journal: Breast Cancer Res Treat Date: 2022-09-09 Impact factor: 4.624