AIM: To analyze the frozen section (FS) diagnostic accuracy in correlation with the final diagnosis of brain tumors. MATERIAL AND METHODS: This retrospective study comprised all brain tumor cases with FS diagnosis and permanent section diagnosis in Jordan University Hospital from July 1, 2007 to December 31, 2017. Data were obtained by reviewing slides and reports from the histopathology archives. Statistical Package for the Social Science (SPSS) software v20 was used for analysis. RESULTS: A total of 179 cases with frozen section and permanent section diagnoses were analyzed. Eighty-four (47%) patients were males and 95 (53%) females.The ages ranged from 1 to 85 years. Diagnostic accuracy of FS was 88.8%. Discrepancy was noted in 20 cases. Of the discrepancies, misclassification of tumor type was the most common category (12 cases, 60%), followed by grading mismatch (7 cases, 35%) and misdiagnosis of tumor versus non-tumor conditions (1 case, 5%). Patient age and gender were not significantly associated with the discrepancy between FS and final diagnosis. CONCLUSION: Our results were comparable to international reports. However, more emphasis on diagnostic cytology in intraoperative consultation is required as an effective adjunct to frozen section to overcome limitations.
AIM: To analyze the frozen section (FS) diagnostic accuracy in correlation with the final diagnosis of brain tumors. MATERIAL AND METHODS: This retrospective study comprised all brain tumor cases with FS diagnosis and permanent section diagnosis in Jordan University Hospital from July 1, 2007 to December 31, 2017. Data were obtained by reviewing slides and reports from the histopathology archives. Statistical Package for the Social Science (SPSS) software v20 was used for analysis. RESULTS: A total of 179 cases with frozen section and permanent section diagnoses were analyzed. Eighty-four (47%) patients were males and 95 (53%) females.The ages ranged from 1 to 85 years. Diagnostic accuracy of FS was 88.8%. Discrepancy was noted in 20 cases. Of the discrepancies, misclassification of tumor type was the most common category (12 cases, 60%), followed by grading mismatch (7 cases, 35%) and misdiagnosis of tumor versus non-tumor conditions (1 case, 5%). Patient age and gender were not significantly associated with the discrepancy between FS and final diagnosis. CONCLUSION: Our results were comparable to international reports. However, more emphasis on diagnostic cytology in intraoperative consultation is required as an effective adjunct to frozen section to overcome limitations.
Authors: Francesco Restelli; Andrea Maria Mathis; Julius Höhne; Elio Mazzapicchi; Francesco Acerbi; Bianca Pollo; Karl Quint Journal: Front Oncol Date: 2022-10-03 Impact factor: 5.738
Authors: Sarah Zulkarnain; Norhayati Yunus; Regunath Kandasamy; Ahmad Badruridzwanullah Zun; Anani Aila Mat Zin Journal: Asian Pac J Cancer Prev Date: 2020-10-01