Literature DB >> 30649532

DNA Methylation Markers of Type 2 Diabetes Mellitus Among Male Veterans With or Without Human Immunodeficiency Virus Infection.

Raina Mathur1, Qin Hui1, Yunfeng Huang1, Marta Gwinn1, Kaku So-Armah2, Matthew S Freiberg3, Amy C Justice4,5, Ke Xu4,6, Vincent C Marconi7,8,9, Yan V Sun1,7,10.   

Abstract

Epigenetic modifications such as DNA methylation are associated with both human immunodeficiency virus (HIV) infection and type 2 diabetes mellitus (T2DM). We investigated epigenetic associations with T2DM according to HIV infection status and assessed interaction effects among 681 male participants of the Veterans Aging Cohort Study. Methylation at previously reported sites, cg1963031 (TXNIP), cg18181703 (SOCS3), and cg09152259 (PROC), was significantly associated with T2DM in HIV-infected individuals. We identified 3 novel associations with suggestive statistical significance: cg1231141 (ADAMTS2), cg19534769 (HGFAC), and cg13163919 (TLE3). Suggestive interaction with HIV infection status was found at cg17862404 (TSC22D1). The implicated genes are involved in inflammation, pancreatic β-cell function, and T2DM pathogenesis.
© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  DNA methylation; HIV; Type 2 Diabetes; epigenome

Mesh：

Substances：

Year:  2019        PMID： 30649532      PMCID： PMC6534194          DOI： 10.1093/infdis/jiz023

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  15 in total

1.  Identification of HIV infection-related DNA methylation sites and advanced epigenetic aging in HIV-positive, treatment-naive U.S. veterans.

Authors:  Kristin N Nelson; Qin Hui; David Rimland; Ke Xu; Matthew S Freiberg; Amy C Justice; Vincent C Marconi; Yan V Sun
Journal:  AIDS       Date:  2017-02-20       Impact factor: 4.177

2.  A critical role for the neural zinc factor ST18 in pancreatic β-cell apoptosis.

Authors:  Cyndi Henry; Anne-Françoise Close; Jean Buteau
Journal:  J Biol Chem       Date:  2014-02-07       Impact factor: 5.157

3.  Comorbidities Among US Patients With Prevalent HIV Infection-A Trend Analysis.

Authors:  Joel Gallant; Priscilla Y Hsue; Sanatan Shreay; Nicole Meyer
Journal:  J Infect Dis       Date:  2017-12-19       Impact factor: 5.226

4.  Identification of hepatocyte growth factor activator (Hgfac) gene as a target of HNF1α in mouse β-cells.

Authors:  Tsuyoshi Ohki; Yoshifumi Sato; Tatsuya Yoshizawa; Ken-ichi Yamamura; Kentaro Yamada; Kazuya Yamagata
Journal:  Biochem Biophys Res Commun       Date:  2012-08-01       Impact factor: 3.575

Review 5.  Activated protein C and its potential applications in prevention of islet β-cell damage and diabetes.

Authors:  Meilang Xue; Christopher J Jackson
Journal:  Vitam Horm       Date:  2014       Impact factor: 3.421

Review 6.  Recent progress in genetic and epigenetic research on type 2 diabetes.

Authors:  Soo Heon Kwak; Kyong Soo Park
Journal:  Exp Mol Med       Date:  2016-03-11       Impact factor: 8.718

7.  Deletion of skeletal muscle SOCS3 prevents insulin resistance in obesity.

Authors:  Sebastian Beck Jorgensen; Hayley M O'Neill; Lykke Sylow; Jane Honeyman; Kimberly A Hewitt; Rengasamy Palanivel; Morgan D Fullerton; Lisa Öberg; Anudharan Balendran; Sandra Galic; Chris van der Poel; Ian A Trounce; Gordon S Lynch; Jonathan D Schertzer; Gregory R Steinberg
Journal:  Diabetes       Date:  2012-09-06       Impact factor: 9.461

8.  DNA methylation arrays as surrogate measures of cell mixture distribution.

Authors:  Eugene Andres Houseman; William P Accomando; Devin C Koestler; Brock C Christensen; Carmen J Marsit; Heather H Nelson; John K Wiencke; Karl T Kelsey
Journal:  BMC Bioinformatics       Date:  2012-05-08       Impact factor: 3.169

9.  TXNIP regulates peripheral glucose metabolism in humans.

Authors:  Hemang Parikh; Emma Carlsson; William A Chutkow; Lovisa E Johansson; Heidi Storgaard; Pernille Poulsen; Richa Saxena; Christine Ladd; P Christian Schulze; Michael J Mazzini; Christine Bjørn Jensen; Anna Krook; Marie Björnholm; Hans Tornqvist; Juleen R Zierath; Martin Ridderstråle; David Altshuler; Richard T Lee; Allan Vaag; Leif C Groop; Vamsi K Mootha
Journal:  PLoS Med       Date:  2007-05       Impact factor: 11.069

10.  Epigenome-wide differential DNA methylation between HIV-infected and uninfected individuals.

Authors:  Xinyu Zhang; Amy C Justice; Ying Hu; Zuoheng Wang; Hongyu Zhao; Guilin Wang; Eric O Johnson; Brinda Emu; Richard E Sutton; John H Krystal; Ke Xu
Journal:  Epigenetics       Date:  2016-09-27       Impact factor: 4.528
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  6 in total

1.  Epigenetic Associations With Estimated Glomerular Filtration Rate Among Men With Human Immunodeficiency Virus Infection.

Authors:  Junyu Chen; Yunfeng Huang; Qin Hui; Raina Mathur; Marta Gwinn; Kaku So-Armah; Matthew S Freiberg; Amy C Justice; Ke Xu; Vincent C Marconi; Yan V Sun
Journal:  Clin Infect Dis       Date:  2020-02-03       Impact factor: 9.079

2.  Association of Cardiovascular Health Through Young Adulthood With Genome-Wide DNA Methylation Patterns in Midlife: The CARDIA Study.

Authors:  Yinan Zheng; Brian T Joyce; Shih-Jen Hwang; Jiantao Ma; Lei Liu; Norrina B Allen; Amy E Krefman; Jun Wang; Tao Gao; Drew R Nannini; Haixiang Zhang; David R Jacobs; Myron D Gross; Myriam Fornage; Cora E Lewis; Pamela J Schreiner; Stephen Sidney; Dongquan Chen; Philip Greenland; Daniel Levy; Lifang Hou; Donald M Lloyd-Jones
Journal:  Circulation       Date:  2022-06-02       Impact factor: 39.918

3.  Increased PARylation impacts the DNA methylation process in type 2 diabetes mellitus.

Authors:  Michele Zampieri; Maria Giulia Bacalini; Ilaria Barchetta; Stefania Scalea; Flavia Agata Cimini; Laura Bertoccini; Stefano Tagliatesta; Giovanna De Matteis; Giuseppe Zardo; Maria Gisella Cavallo; Anna Reale
Journal:  Clin Epigenetics       Date:  2021-05-17       Impact factor: 6.551

4.  Chronic HIV infection induces transcriptional and functional reprogramming of innate immune cells.

Authors:  Wouter A van der Heijden; Lisa Van de Wijer; Farid Keramati; Wim Trypsteen; Sofie Rutsaert; Rob Ter Horst; Martin Jaeger; Hans Jpm Koenen; Hendrik G Stunnenberg; Irma Joosten; Paul E Verweij; Jan van Lunzen; Charles A Dinarello; Leo Ab Joosten; Linos Vandekerckhove; Mihai G Netea; André Jam van der Ven; Quirijn de Mast
Journal:  JCI Insight       Date:  2021-04-08

Review 5.  Epigenome-wide epidemiologic studies of human immunodeficiency virus infection, treatment, and disease progression.

Authors:  Boghuma K Titanji; Marta Gwinn; Vincent C Marconi; Yan V Sun
Journal:  Clin Epigenetics       Date:  2022-01-11       Impact factor: 6.551

6.  DNA methylation biomarker selected by an ensemble machine learning approach predicts mortality risk in an HIV-positive veteran population.

Authors:  Chang Shu; Amy C Justice; Xinyu Zhang; Vincent C Marconi; Dana B Hancock; Eric O Johnson; Ke Xu
Journal:  Epigenetics       Date:  2020-10-22       Impact factor: 4.528
  6 in total

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