Literature DB >> 30649198

RNF216 is essential for spermatogenesis and male fertility†.

Ashley F Melnick1, Yuen Gao1, Jiali Liu1,2, Deqiang Ding1, Alicia Predom1, Catherine Kelly1, Rex A Hess3, Chen Chen1,4,5.   

Abstract

Ring finger protein 216 (RNF216) belongs to the RING family of E3 ubiquitin ligases that are involved in cellular protein degradation. Mutations in human Rnf216 gene have been identified in Gordon Holmes syndrome, which is defined by ataxia, dementia, and hypogonadotropism. However, the gene function of Rnf216 in mammalian species remains unknown. Here, we show that targeted deletion of Rnf216 in mice results in disruption in spermatogenesis and male infertility. RNF216 is not required for female fertility. These findings reveal an essential function of RNF216 in spermatogenesis and male fertility and suggest a critical role for RNF216 in human gonadal development.
© The Author(s) 2019. Published by Oxford University Press on behalf of Society for the Study of Reproduction.

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Year:  2019        PMID： 30649198      PMCID： PMC6698654          DOI： 10.1093/biolre/ioz006

Source DB:  PubMed          Journal:  Biol Reprod        ISSN： 0006-3363            Impact factor:   4.285


  9 in total

1.  Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors.

Authors:  Tsung-Hsien Chuang; Richard J Ulevitch
Journal:  Nat Immunol       Date:  2004-04-25       Impact factor: 25.606

2.  RNF216 mutations as a novel cause of autosomal recessive Huntington-like disorder.

Authors:  Patrick Santens; Tim Van Damme; Wouter Steyaert; Andy Willaert; Bernard Sablonnière; Anne De Paepe; Paul J Coucke; Bart Dermaut
Journal:  Neurology       Date:  2015-04-03       Impact factor: 9.910

3.  Ataxia, dementia, and hypogonadotropism caused by disordered ubiquitination.

Authors:  David H Margolin; Maria Kousi; Yee-Ming Chan; Elaine T Lim; Jeremy D Schmahmann; Marios Hadjivassiliou; Janet E Hall; Ibrahim Adam; Andrew Dwyer; Lacey Plummer; Stephanie V Aldrin; Julia O'Rourke; Andrew Kirby; Kasper Lage; Aubrey Milunsky; Jeff M Milunsky; Jennifer Chan; E Tessa Hedley-Whyte; Mark J Daly; Nicholas Katsanis; Stephanie B Seminara
Journal:  N Engl J Med       Date:  2013-05-08       Impact factor: 91.245

4.  A conditional knockout resource for the genome-wide study of mouse gene function.

Authors:  William C Skarnes; Barry Rosen; Anthony P West; Manousos Koutsourakis; Wendy Bushell; Vivek Iyer; Alejandro O Mujica; Mark Thomas; Jennifer Harrow; Tony Cox; David Jackson; Jessica Severin; Patrick Biggs; Jun Fu; Michael Nefedov; Pieter J de Jong; A Francis Stewart; Allan Bradley
Journal:  Nature       Date:  2011-06-15       Impact factor: 49.962

5.  Triad3A regulates synaptic strength by ubiquitination of Arc.

Authors:  Angela M Mabb; H Shawn Je; Mark J Wall; Camenzind G Robinson; Rylan S Larsen; Yuan Qiang; Sonia A L Corrêa; Michael D Ehlers
Journal:  Neuron       Date:  2014-06-18       Impact factor: 17.173

6.  TRIAD3/RNF216 mutations associated with Gordon Holmes syndrome lead to synaptic and cognitive impairments via Arc misregulation.

Authors:  Nilofer Husain; Qiang Yuan; Yi-Chun Yen; Olga Pletnikova; Dong Qianying Sally; Paul Worley; Zoë Bichler; H Shawn Je
Journal:  Aging Cell       Date:  2016-12-20       Impact factor: 9.304

7.  The E3 ubiquitin ligase Triad3A negatively regulates the RIG-I/MAVS signaling pathway by targeting TRAF3 for degradation.

Authors:  Peyman Nakhaei; Thibault Mesplede; Mayra Solis; Qiang Sun; Tiejun Zhao; Long Yang; Tsung-Hsien Chuang; Carl F Ware; Rongtuan Lin; John Hiscott
Journal:  PLoS Pathog       Date:  2009-11-06       Impact factor: 6.823

8.  The mammalian gene function resource: the International Knockout Mouse Consortium.

Authors:  Allan Bradley; Konstantinos Anastassiadis; Abdelkader Ayadi; James F Battey; Cindy Bell; Marie-Christine Birling; Joanna Bottomley; Steve D Brown; Antje Bürger; Carol J Bult; Wendy Bushell; Francis S Collins; Christian Desaintes; Brendan Doe; Aris Economides; Janan T Eppig; Richard H Finnell; Colin Fletcher; Martin Fray; David Frendewey; Roland H Friedel; Frank G Grosveld; Jens Hansen; Yann Hérault; Geoffrey Hicks; Andreas Hörlein; Richard Houghton; Martin Hrabé de Angelis; Danny Huylebroeck; Vivek Iyer; Pieter J de Jong; James A Kadin; Cornelia Kaloff; Karen Kennedy; Manousos Koutsourakis; K C Kent Lloyd; Susan Marschall; Jeremy Mason; Colin McKerlie; Michael P McLeod; Harald von Melchner; Mark Moore; Alejandro O Mujica; Andras Nagy; Mikhail Nefedov; Lauryl M Nutter; Guillaume Pavlovic; Jane L Peterson; Jonathan Pollock; Ramiro Ramirez-Solis; Derrick E Rancourt; Marcello Raspa; Jacques E Remacle; Martin Ringwald; Barry Rosen; Nadia Rosenthal; Janet Rossant; Patricia Ruiz Noppinger; Ed Ryder; Joel Zupicich Schick; Frank Schnütgen; Paul Schofield; Claudia Seisenberger; Mohammed Selloum; Elizabeth M Simpson; William C Skarnes; Damian Smedley; William L Stanford; A Francis Stewart; Kevin Stone; Kate Swan; Hamsa Tadepally; Lydia Teboul; Glauco P Tocchini-Valentini; David Valenzuela; Anthony P West; Ken-ichi Yamamura; Yuko Yoshinaga; Wolfgang Wurst
Journal:  Mamm Genome       Date:  2012-09-12       Impact factor: 2.957

9.  Regulation of autophagy by E3 ubiquitin ligase RNF216 through BECN1 ubiquitination.

Authors:  Congfeng Xu; Kuan Feng; Xiaonan Zhao; Shiqian Huang; Yiji Cheng; Liu Qian; Yanan Wang; Hongxing Sun; Min Jin; Tsung-Hsien Chuang; Yanyun Zhang
Journal:  Autophagy       Date:  2014       Impact factor: 16.016
  9 in total
  7 in total

1.  RNF216 Alleviates Radiation-Induced Apoptosis and DNA Damage Through Regulating Ubiquitination-Mediated Degradation of p53 in Glioblastoma.

Authors:  Songwang Xie; Zhen Hong; Yan Li; Junyong Wang; Jian Wang; Shaoquan Li; Yongchang Liu
Journal:  Mol Neurobiol       Date:  2022-05-20       Impact factor: 5.682

2.  The E3 ubiquitin ligase RNF216/TRIAD3 is a key coordinator of the hypothalamic-pituitary-gonadal axis.

Authors:  Arlene J George; Bin Dong; Hannah Lail; Morgan Gomez; Yarely C Hoffiz; Christopher B Ware; Ning Fang; Anne Z Murphy; Erik Hrabovszky; Desiree Wanders; Angela M Mabb
Journal:  iScience       Date:  2022-05-10

Review 3.  Ubiquitin ligases: guardians of mammalian development.

Authors:  David A Cruz Walma; Zhuoyao Chen; Alex N Bullock; Kenneth M Yamada
Journal:  Nat Rev Mol Cell Biol       Date:  2022-01-25       Impact factor: 113.915

Review 4.  Proteolysis in Reproduction: Lessons From Gene-Modified Organism Studies.

Authors:  Daiji Kiyozumi; Masahito Ikawa
Journal:  Front Endocrinol (Lausanne)       Date:  2022-05-04       Impact factor: 6.055

5.  Multi-organ proteomic landscape of COVID-19 autopsies.

Authors:  Xiu Nie; Liujia Qian; Rui Sun; Bo Huang; Xiaochuan Dong; Qi Xiao; Qiushi Zhang; Tian Lu; Liang Yue; Shuo Chen; Xiang Li; Yaoting Sun; Lu Li; Luang Xu; Yan Li; Ming Yang; Zhangzhi Xue; Shuang Liang; Xuan Ding; Chunhui Yuan; Li Peng; Wei Liu; Xiao Yi; Mengge Lyu; Guixiang Xiao; Xia Xu; Weigang Ge; Jiale He; Jun Fan; Junhua Wu; Meng Luo; Xiaona Chang; Huaxiong Pan; Xue Cai; Junjie Zhou; Jing Yu; Huanhuan Gao; Mingxing Xie; Sihua Wang; Guan Ruan; Hao Chen; Hua Su; Heng Mei; Danju Luo; Dashi Zhao; Fei Xu; Yan Li; Yi Zhu; Jiahong Xia; Yu Hu; Tiannan Guo
Journal:  Cell       Date:  2021-01-09       Impact factor: 41.582

Review 6.  Human semen quality as affected by SARS-CoV-2 infection: An up-to-date review.

Authors:  Saleem Ali Banihani
Journal:  Andrologia       Date:  2021-10-30       Impact factor: 2.532

Review 7.  Application of CRISPR/Cas Technology in Spermatogenesis Research and Male Infertility Treatment.

Authors:  Hao-Qi Wang; Tian Wang; Fei Gao; Wen-Zhi Ren
Journal:  Genes (Basel)       Date:  2022-06-01       Impact factor: 4.141
  7 in total

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