Frédéric Lapostolle1,2,3, Sophie Bataille4, Aurélie Loyeau5, Benoît Simon6, François-Xavier Laborne6, François Dupas7, Thévy Boche8, Lionel Lamhaut9, Virginie Pirès10, Hugues Lefort11, Mireille Mapouata4, Gaëlle Le Bail12, Lisa Weisslinger1,2, Jean-Michel Juliard13, Yves Lambert14. 1. SAMU 93, UF Recherche-Enseignement-Qualité, Avicenne Hospital-APHP, Bobigny. 2. Université Paris 13, Sorbonne Paris Cité, Paris. 3. INSERM Unit 942, Bobigny. 4. Registry Department, Regional Health Agency in Great Paris Area. 5. GCS SESAN, Information Processing Department, Paris. 6. SAMU 91, Sud Francilien Hospital, Corbeil-Essonnes. 7. SAMU 95, Pontoise Hospital, Pontoise. 8. SAMU 94, Mondor Hospital-APHP, Créteil. 9. SAMU 75, Necker Hospital-APHP, Paris. 10. SAMU 77, Melun Hospital, Melun. 11. EMS Department, Fire Department of Paris, Paris. 12. SAMU 92, Garches Hospital-APHP, Garches. 13. Cardiology Department, Bichat Hospital-APHP, DHU FIRE, Université Paris Diderot, Sorbonne Paris-Cité, INSERM U-1148 Paris, Paris. 14. SAMU 78, Versailles Hospital, Le Chesnay, France.
Abstract
OBJECTIVE: Mortality in patients with ST-segment elevation myocardial infarction (STEMI) has been associated with the volume of activity of percutaneous coronary intervention (PCI) facilities. This observational study investigated whether the coronary reperfusion-decision rate is associated with the volume of activity in a prehospital emergency setting. METHODS: Prospectively collected data for the period 2003-2013 were extracted from a regional registry of all STEMI patients handled by eight dispatch centers (SAMUs) in and around Paris [41 mobile ICU (MICUs)]. A possible association between volume of activity (number of STEMIs) and coronary reperfusion-decision rate, and subsidiarily between volume of activity and choice of technique (fibrinolysis vs. primary PCI), were investigated. Explanatory factors (patient age, sex, delay between pain onset and first medical contact, and access to a PCI facility) were analyzed in a multivariate analysis. RESULTS: Overall, 18 162 patients; male/female 3.5/1; median age 62 (52-72) years were included in the analysis. The median number of STEMIs per MICU was 339 (IQ 220-508) and that of reperfusion-decisions was 94% (91-95). There was no association between the decision rate and the number of STEMIs (P = 0.1). However, the decision rate was associated with age, sex, delay, and access to a PCI facility (P < 0.0001) in a highly significant way. Fibrinolysis was a more frequent option for low-volume (remoter PCI facilities) than high-volume MICUs (30 vs. 16%). CONCLUSION: The decision of coronary reperfusion in a prehospital emergency setting depended on patient characteristics, delay between pain onset and first medical contact, and access to a PCI facility, but not on volume of activity. Promoting fibrinolysis use in underserved areas might help increase the reperfusion-decision rate.
OBJECTIVE: Mortality in patients with ST-segment elevation myocardial infarction (STEMI) has been associated with the volume of activity of percutaneous coronary intervention (PCI) facilities. This observational study investigated whether the coronary reperfusion-decision rate is associated with the volume of activity in a prehospital emergency setting. METHODS: Prospectively collected data for the period 2003-2013 were extracted from a regional registry of all STEMI patients handled by eight dispatch centers (SAMUs) in and around Paris [41 mobile ICU (MICUs)]. A possible association between volume of activity (number of STEMIs) and coronary reperfusion-decision rate, and subsidiarily between volume of activity and choice of technique (fibrinolysis vs. primary PCI), were investigated. Explanatory factors (patient age, sex, delay between pain onset and first medical contact, and access to a PCI facility) were analyzed in a multivariate analysis. RESULTS: Overall, 18 162 patients; male/female 3.5/1; median age 62 (52-72) years were included in the analysis. The median number of STEMIs per MICU was 339 (IQ 220-508) and that of reperfusion-decisions was 94% (91-95). There was no association between the decision rate and the number of STEMIs (P = 0.1). However, the decision rate was associated with age, sex, delay, and access to a PCI facility (P < 0.0001) in a highly significant way. Fibrinolysis was a more frequent option for low-volume (remoter PCI facilities) than high-volume MICUs (30 vs. 16%). CONCLUSION: The decision of coronary reperfusion in a prehospital emergency setting depended on patient characteristics, delay between pain onset and first medical contact, and access to a PCI facility, but not on volume of activity. Promoting fibrinolysis use in underserved areas might help increase the reperfusion-decision rate.
Authors: Harald Dormann; Patrick Andreas Eder; Henner Gimpel; Oliver Meindl; Asarnusch Rashid; Christian Regal Journal: J Med Syst Date: 2020-05-08 Impact factor: 4.460