Literature DB >> 3064853

Induction of rat gastric damage by the endothelium-derived peptide, endothelin.

B J Whittle1, J V Esplugues.   

Abstract

The effect of the endogenous vasoconstrictor peptide, endothelin, on gastric mucosal integrity has been investigated in the rat. Local intra-arterial infusion of endothelin, in picomole doses, dose-dependently induced haemorrhagic and necrotic damage in the gastric mucosa. Such injury was not prevented by atropine, cimetidine, adrenoceptor antagonists, indomethacin, or the 5-lipoxygenase inhibitor BW A4C. These results suggest a potential pro-ulcerogenic role of endothelin in the pathogenesis of gastric damage and ulceration.

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Year:  1988        PMID： 3064853      PMCID： PMC1854285          DOI： 10.1111/j.1476-5381.1988.tb11733.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  5 in total

1.  A novel potent vasoconstrictor peptide produced by vascular endothelial cells.

Authors:  M Yanagisawa; H Kurihara; S Kimura; Y Tomobe; M Kobayashi; Y Mitsui; Y Yazaki; K Goto; T Masaki
Journal:  Nature       Date:  1988-03-31       Impact factor: 49.962

2.  Close-arterial administration of the thromboxane mimetic U-46619 induces damage to the rat gastric mucosa.

Authors:  J V Esplugues; B J Whittle
Journal:  Prostaglandins       Date:  1988-02

3.  Gastric mucosal damage induced by local intra-arterial administration of Paf in the rat.

Authors:  J V Esplugues; B J Whittle
Journal:  Br J Pharmacol       Date:  1988-01       Impact factor: 8.739

4.  Vasoconstriction with thromboxane A2 induces ulceration of the gastric mucosa.

Authors:  B J Whittle; G L Kauffman; S Moncada
Journal:  Nature       Date:  1981-07-30       Impact factor: 49.962

5.  Selective inhibition of arachidonate 5-lipoxygenase by novel acetohydroxamic acids: biochemical assessment in vitro and ex vivo.

Authors:  J E Tateson; R W Randall; C H Reynolds; W P Jackson; P Bhattacherjee; J A Salmon; L G Garland
Journal:  Br J Pharmacol       Date:  1988-06       Impact factor: 8.739
  5 in total
  18 in total

1.  Endothelin-like pulmonary vasoconstrictor peptide release by alpha-thrombin.

Authors:  D G Moon; M J Horgan; T T Andersen; S R Krystek; J W Fenton; A B Malik
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

2.  Direct positive inotropic and vasoconstrictor effects of endothelin.

Authors:  M R Siegfried; N Aoki; D Mulloy; A M Lefer
Journal:  Heart Vessels       Date:  1990       Impact factor: 2.037

3.  Intragastric alcohol causes endothelin release from feline pancreas.

Authors:  M P Lewis; P U Reber; A M Kusske; M T Toyama; K E Todd; S W Ashley; H A Reber
Journal:  Dig Dis Sci       Date:  1998-05       Impact factor: 3.199

4.  Regulation of gastric mucosal integrity by endogenous nitric oxide: interactions with prostanoids and sensory neuropeptides in the rat.

Authors:  B J Whittle; J Lopez-Belmonte; S Moncada
Journal:  Br J Pharmacol       Date:  1990-03       Impact factor: 8.739

Review 5.  Thirteenth Gaddum Memorial Lecture. Neuronal and endothelium-derived mediators in the modulation of the gastric microcirculation: integrity in the balance.

Authors:  B J Whittle
Journal:  Br J Pharmacol       Date:  1993-09       Impact factor: 8.739

6.  The involvement of endothelial dysfunction, nitric oxide and prostanoids in the rat gastric microcirculatory responses to endothelin-1.

Authors:  J Lopez-Belmonte; B J Whittle
Journal:  Br J Pharmacol       Date:  1994-05       Impact factor: 8.739

7.  Submucosal microinfusion of endothelin and adrenaline mobilizes ECL-cell histamine in rat stomach, and causes mucosal damage: a microdialysis study.

Authors:  M Bernsand; P Ericsson; M Bjorkqvist; C-M Zhao; R Hakanson; P Norlen
Journal:  Br J Pharmacol       Date:  2003-09-22       Impact factor: 8.739

8.  The development of the endothelin-1-induced gastric ulcer: time sequence analysis of morphologic changes.

Authors:  L Spyridon; N Akira; K Hiromasa; G Katsutoshi; M Takao; O Yoshiki; S Hideo; F Hisayuki
Journal:  Int J Exp Pathol       Date:  1994-10       Impact factor: 1.925

9.  The paradoxical vascular interactions between endothelin-1 and calcitonin gene-related peptide in the rat gastric mucosal microcirculation.

Authors:  J Lopez-Belmonte; B J Whittle
Journal:  Br J Pharmacol       Date:  1993-09       Impact factor: 8.739

10.  Involvement of superoxide and xanthine oxidase in neutrophil-independent rat gastric damage induced by NO donors.

Authors:  D Lamarque; B J Whittle
Journal:  Br J Pharmacol       Date:  1995-09       Impact factor: 8.739
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