Luisa Servioli1,2, Gabriel Maciel1,2, Carlotta Nannini1,2, Cynthia S Crowson1,2, Eric L Matteson3,4, Divi Cornec1,2, Alvise Berti1,2. 1. From the Division of Rheumatology, and Division of Biomedical Statistics and Informatics, and Division of Epidemiology, and Division of Pulmonary and Critical Care Medicine, Department of Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; Autoimmune Diseases Department, Medical Clinic 1, Hospital Maciel, Montevideo, Uruguay; Department of Rheumatology, Hospital of Prato, Prato, Italy; Rheumatology Department, Brest Teaching Hospital, Brest, France; Immunology, Rheumatology, Allergy and Rare Diseases Department, San Raffaele Scientific Institute, Milan, Italy; Rheumatology Department, Santa Chiara Hospital, Trento, Italy. 2. L. Servioli, MD, Division of Rheumatology, Mayo Clinic College of Medicine and Science, and Autoimmune diseases Department, Medical Clinic 1, Hospital Maciel; G. Maciel, MD, Autoimmune Diseases Department, Medical Clinic 1, Hospital Maciel; C. Nannini, MD, Division of Rheumatology, Mayo Clinic College of Medicine and Science, and Department of Rheumatology, Hospital of Prato; C.S. Crowson, PhD, Division of Rheumatology, and Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine and Science; E.L. Matteson, MD, MPH, Division of Rheumatology, and Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine and Science; D. Cornec, MD, PhD, Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine and Science, and Rheumatology Department, Brest Teaching Hospital; A. Berti, MD, Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine and Science, and the Immunology, Rheumatology, Allergy and Rare Diseases Department, San Raffaele Scientific Institute, and the Rheumatology Department, Santa Chiara Hospital. 3. From the Division of Rheumatology, and Division of Biomedical Statistics and Informatics, and Division of Epidemiology, and Division of Pulmonary and Critical Care Medicine, Department of Health Sciences Research, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA; Autoimmune Diseases Department, Medical Clinic 1, Hospital Maciel, Montevideo, Uruguay; Department of Rheumatology, Hospital of Prato, Prato, Italy; Rheumatology Department, Brest Teaching Hospital, Brest, France; Immunology, Rheumatology, Allergy and Rare Diseases Department, San Raffaele Scientific Institute, Milan, Italy; Rheumatology Department, Santa Chiara Hospital, Trento, Italy. Matteson.eric@mayo.edu. 4. L. Servioli, MD, Division of Rheumatology, Mayo Clinic College of Medicine and Science, and Autoimmune diseases Department, Medical Clinic 1, Hospital Maciel; G. Maciel, MD, Autoimmune Diseases Department, Medical Clinic 1, Hospital Maciel; C. Nannini, MD, Division of Rheumatology, Mayo Clinic College of Medicine and Science, and Department of Rheumatology, Hospital of Prato; C.S. Crowson, PhD, Division of Rheumatology, and Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine and Science; E.L. Matteson, MD, MPH, Division of Rheumatology, and Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine and Science; D. Cornec, MD, PhD, Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine and Science, and Rheumatology Department, Brest Teaching Hospital; A. Berti, MD, Division of Pulmonary and Critical Care Medicine, Mayo Clinic College of Medicine and Science, and the Immunology, Rheumatology, Allergy and Rare Diseases Department, San Raffaele Scientific Institute, and the Rheumatology Department, Santa Chiara Hospital. Matteson.eric@mayo.edu.
Abstract
OBJECTIVE: To explore the role of smoking and obesity in primary Sjögren syndrome (pSS). METHODS: Olmsted County (Minnesota, USA) residents (n = 106) diagnosed with pSS from 2000 to 2015 were compared to 3 controls without pSS and matched for age and sex who were randomly selected from Olmsted County residents. RESULTS: Current smokers were less likely to be pSS cases (OR 0.34, 95% CI 0.14-0.85), while there was no association between former smoking and case/control status (OR 1.27, 95% CI 0.80-2.03) compared to never smokers. Smoking status was not associated with antinuclear antibody, anti-SSA, anti-SSB, or rheumatoid factor positivity (p > 0.05). OR for obesity was 0.79 (95% CI 0.48-1.30). CONCLUSION: In this population-based study, current smoking was inversely associated with case/control status, while body mass index lacked any association.
OBJECTIVE: To explore the role of smoking and obesity in primary Sjögren syndrome (pSS). METHODS: Olmsted County (Minnesota, USA) residents (n = 106) diagnosed with pSS from 2000 to 2015 were compared to 3 controls without pSS and matched for age and sex who were randomly selected from Olmsted County residents. RESULTS: Current smokers were less likely to be pSS cases (OR 0.34, 95% CI 0.14-0.85), while there was no association between former smoking and case/control status (OR 1.27, 95% CI 0.80-2.03) compared to never smokers. Smoking status was not associated with antinuclear antibody, anti-SSA, anti-SSB, or rheumatoid factor positivity (p > 0.05). OR for obesity was 0.79 (95% CI 0.48-1.30). CONCLUSION: In this population-based study, current smoking was inversely associated with case/control status, while body mass index lacked any association.
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