Ashwani Kumar Sachdeva1, Prasanth Penumadu2, Pavneet Kohli3, Biswajit Dubashi4, Hemachandren Munuswamy5. 1. 1 Balco Medical Center, Raipur, India. 2. 2 Department of Surgical Oncology, Jawaharlal Institute of Postgraduate Medical Education & Research, Pondicherry, India. 3. 3 Department of Surgical Oncology, Jawaharlal Institute of Postgraduate Medical Education & Research, Pondicherry, India. 4. 4 Department of Medical Oncology, Jawaharlal Institute of Postgraduate Medical Education & Research, Pondicherry, India. 5. 5 Department of Cardiovascular and Thoracic Surgery, Jawaharlal Institute of Postgraduate Medical Education & Research, Pondicherry, India.
Abstract
BACKGROUND: Growing teratoma syndrome is a rare phenomenon seen in nonseminomatous germ cell tumors after chemotherapy, where the tumor grows paradoxically despite normalization of tumor markers. It has been found in various locations, most commonly, the retroperitoneum in association with metastatic disease. The occurrence of growing teratoma syndrome in a mediastinal primary is very rare and there are only a few reports in the literature. METHODS: In a retrospective review, out of 12 patients with mediastinal involvement by a germ cell tumor, 5 had a primary from the mediastinum. We present a series of 3 cases of primary germ cell tumor of the mediastinum, which after chemotherapy, fulfilled the criteria for growing teratoma syndrome and were managed with surgical excision. CONCLUSION: Development of growing teratoma syndrome in a primary mediastinal germ cell tumor is extremely rare. Its awareness and early detection can lead to successful surgical excision and long-term cure.
BACKGROUND: Growing teratoma syndrome is a rare phenomenon seen in nonseminomatous germ cell tumors after chemotherapy, where the tumor grows paradoxically despite normalization of tumor markers. It has been found in various locations, most commonly, the retroperitoneum in association with metastatic disease. The occurrence of growing teratoma syndrome in a mediastinal primary is very rare and there are only a few reports in the literature. METHODS: In a retrospective review, out of 12 patients with mediastinal involvement by a germ cell tumor, 5 had a primary from the mediastinum. We present a series of 3 cases of primary germ cell tumor of the mediastinum, which after chemotherapy, fulfilled the criteria for growing teratoma syndrome and were managed with surgical excision. CONCLUSION: Development of growing teratoma syndrome in a primary mediastinal germ cell tumor is extremely rare. Its awareness and early detection can lead to successful surgical excision and long-term cure.
Authors: Richard Zheng; Courtney L Devin; Thomas O'Malley; Francesco Palazzo; Nathaniel R Evans Journal: Surg Endosc Date: 2019-10-28 Impact factor: 4.584
Authors: Stefan Sponholz; Kyriaki Chalepaki Ntelli; Georgios Karaindros; Moritz Schirren; Anja Lorch; Andreas Hiester; Peter Albers; Joachim Schirren Journal: World J Urol Date: 2020-10-31 Impact factor: 4.226