Fabrizia Falco1, Marcello Moccia2, Alessandro Chiodi3, Antonio Carotenuto1, Angelo D'Amelio3, Laura Rosa4, Kyrie Piscopo4, Andrea Falco1, Teresa Costabile1, Francesca Lauro1, Vincenzo Brescia Morra1, Roberta Lanzillo1. 1. Multiple Sclerosis Clinical Care and Research Centre, Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II University, Via Sergio Pansini, 5 - Building 17, Ground floor, Naples, Italy. 2. Multiple Sclerosis Clinical Care and Research Centre, Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II University, Via Sergio Pansini, 5 - Building 17, Ground floor, Naples, Italy. moccia.marcello@gmail.com. 3. Clinical Psychology Unit, Department of Neuroscience, Reproductive Science and Odontostomatology, Federico II University, Naples, Italy. 4. Active Inclusion and Student Participation Service, Federico II University of Naples, Naples, Italy.
Abstract
AIM: The Brief Repeatable Battery of Neuropsychological Tests (BRB) is frequently used to estimate cognitive function in adults with multiple sclerosis (MS), while it has been included in few studies on young MS, also because of the absence of normative values. We aim to evaluate the impact of age, gender, and education on BRB scores in a young adolescent population. METHODS: We administered the BRB to 76, 14-to-17-year-old, healthy subjects. Linear regression models were used to assess the impact of age, gender, and education on sub-test scores. When statistically significant (p < 0.05), we used the regression coefficient to correct the raw scores. RESULTS: Younger age was associated with better performance on SPART (β = - 2.54; p < 0.05) and SPART-D (β = - 1.06; p < 0.05). Male gender was associated with better performance on SPART (β = 3.40; p < 0.05), SPART-D (β = 1.41; p < 0.05), PASAT-3 (β = 5.58; p < 0.05), and PASAT-2 (β = 5.07; p < 0.05). Educational attainments were associated with better performance on SPART (β = 3.23; p < 0.05) and SPART-D (β = 1.28; p < 0.05). Cut-off points were suggested at the 5th lowest percentile. INTERPRETATION: Age, gender, and education must be accounted for when applying the BRB to young population. Present results can prove useful for future clinical and research applications in adolescent MS patients.
AIM: The Brief Repeatable Battery of Neuropsychological Tests (BRB) is frequently used to estimate cognitive function in adults with multiple sclerosis (MS), while it has been included in few studies on young MS, also because of the absence of normative values. We aim to evaluate the impact of age, gender, and education on BRB scores in a young adolescent population. METHODS: We administered the BRB to 76, 14-to-17-year-old, healthy subjects. Linear regression models were used to assess the impact of age, gender, and education on sub-test scores. When statistically significant (p < 0.05), we used the regression coefficient to correct the raw scores. RESULTS: Younger age was associated with better performance on SPART (β = - 2.54; p < 0.05) and SPART-D (β = - 1.06; p < 0.05). Male gender was associated with better performance on SPART (β = 3.40; p < 0.05), SPART-D (β = 1.41; p < 0.05), PASAT-3 (β = 5.58; p < 0.05), and PASAT-2 (β = 5.07; p < 0.05). Educational attainments were associated with better performance on SPART (β = 3.23; p < 0.05) and SPART-D (β = 1.28; p < 0.05). Cut-off points were suggested at the 5th lowest percentile. INTERPRETATION: Age, gender, and education must be accounted for when applying the BRB to young population. Present results can prove useful for future clinical and research applications in adolescent MS patients.
Authors: M P Amato; E Portaccio; B Goretti; V Zipoli; L Ricchiuti; M F De Caro; F Patti; R Vecchio; S Sorbi; M Trojano Journal: Mult Scler Date: 2006-12 Impact factor: 6.312
Authors: R Lanzillo; A Chiodi; A Carotenuto; V Magri; A Napolitano; R Liuzzi; T Costabile; N Rainone; M F Freda; P Valerio; V Brescia Morra Journal: Eur J Paediatr Neurol Date: 2015-09-03 Impact factor: 3.140
Authors: M P Amato; B Goretti; A Ghezzi; S Lori; V Zipoli; E Portaccio; L Moiola; M Falautano; M F De Caro; M Lopez; F Patti; R Vecchio; C Pozzilli; V Bianchi; M Roscio; G Comi; M Trojano Journal: Neurology Date: 2008-05-13 Impact factor: 9.910
Authors: E Portaccio; B Goretti; S Lori; V Zipoli; S Centorrino; A Ghezzi; F Patti; V Bianchi; G Comi; M Trojano; M P Amato Journal: Mult Scler Date: 2009-03-24 Impact factor: 6.312