Literature DB >> 30645002

Alcohol-Related Liver Disease: Areas of Consensus, Unmet Needs and Opportunities for Further Study.

Gyongyi Szabo1, Patrick S Kamath2, Vijay H Shah2, Mark Thursz3, Philippe Mathurin4.   

Abstract

A joint meeting of the European Association for the Study of the Liver (EASL) and the American Association for the Study of Liver Diseases (AASLD) was held in London on September 30 and October 1, 2017. The goals of the meeting were to identify areas of broad agreement and disagreement, develop consensus, and determine future directions to ultimately reduce the burden, morbidity, and mortality of alcohol-related liver disease (previously termed alcoholic liver disease). The specific aims of the meeting were to identify unmet needs and areas for future investigation, in order to reduce alcohol consumption, develop markers for diagnosis and prognosis of disease, and create a framework to test novel pharmacological agents with pre-specified treatment endpoints. A table summary of these goals and aims is provided in the context of epidemiology, current management strategies, next steps for future trials and translational science.
© 2019 by the American Association for the Study of Liver Diseases and the European Association for the Study of the Liver.

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Year:  2019        PMID: 30645002     DOI: 10.1002/hep.30369

Source DB:  PubMed          Journal:  Hepatology        ISSN: 0270-9139            Impact factor:   17.425


  22 in total

1.  Hepatic injury and inflammation alter ethanol metabolism and drinking behavior.

Authors:  Tianyi Ren; Bryan Mackowiak; Yuhong Lin; Yanhang Gao; Junqi Niu; Bin Gao
Journal:  Food Chem Toxicol       Date:  2019-12-21       Impact factor: 6.023

2.  Biomarkers of Macrophage Activation and Immune Danger Signals Predict Clinical Outcomes in Alcoholic Hepatitis.

Authors:  Banishree Saha; David Tornai; Karen Kodys; Adeyinka Adejumo; Patrick Lowe; Craig McClain; Mack Mitchell; Arthur McCullough; Srinivasan Dasarathy; Aimee Kroll-Desrosiers; Bruce Barton; Svetlana Radaeva; Gyongyi Szabo
Journal:  Hepatology       Date:  2019-05-27       Impact factor: 17.425

Review 3.  The knowns and unknowns of treatment for alcoholic hepatitis.

Authors:  Tejasav S Sehrawat; Mengfei Liu; Vijay H Shah
Journal:  Lancet Gastroenterol Hepatol       Date:  2020-05

Review 4.  Neutrophil Extracellular Traps and Liver Disease.

Authors:  Moira B Hilscher; Vijay H Shah
Journal:  Semin Liver Dis       Date:  2019-11-14       Impact factor: 6.115

5.  Targeting liver aldehyde dehydrogenase-2 prevents heavy but not moderate alcohol drinking.

Authors:  Adrien Guillot; Tianyi Ren; Tony Jourdan; Robert J Pawlosky; Elaine Han; Seung-Jin Kim; Li Zhang; George F Koob; Bin Gao
Journal:  Proc Natl Acad Sci U S A       Date:  2019-12-02       Impact factor: 11.205

Review 6.  Interleukin-22 in alcoholic hepatitis and beyond.

Authors:  Xiaogang Xiang; Seonghwan Hwang; Dechun Feng; Vijay H Shah; Bin Gao
Journal:  Hepatol Int       Date:  2020-09-05       Impact factor: 6.047

7.  Chronic-plus-binge alcohol intake induces production of proinflammatory mtDNA-enriched extracellular vesicles and steatohepatitis via ASK1/p38MAPKα-dependent mechanisms.

Authors:  Jing Ma; Haixia Cao; Robim M Rodrigues; Mingjiang Xu; Tianyi Ren; Yong He; Seonghwan Hwang; Dechun Feng; Ruixue Ren; Peixin Yang; Suthat Liangpunsakul; Jian Sun; Bin Gao
Journal:  JCI Insight       Date:  2020-07-23

8.  Multivariable-adjusted trends in mortality due to alcoholic liver disease among adults in the United States, from 1999-2017.

Authors:  Emily Ryu; Harry H Xia; Grace L Guo; Lanjing Zhang
Journal:  Am J Transl Res       Date:  2022-02-15       Impact factor: 4.060

9.  Circulating Extracellular Vesicles Carrying Sphingolipid Cargo for the Diagnosis and Dynamic Risk Profiling of Alcoholic Hepatitis.

Authors:  Tejasav S Sehrawat; Juan P Arab; Mengfei Liu; Pouya Amrollahi; Meihua Wan; Jia Fan; Yasuhiko Nakao; Elisa Pose; Amaia Navarro-Corcuera; Debanjali Dasgupta; Chieh-Yu Liao; Li He; Amy S Mauer; Emma Avitabile; Meritxell Ventura-Cots; Ramon A Bataller; Arun J Sanyal; Naga P Chalasani; Julie K Heimbach; Kymberly D Watt; Gregory J Gores; Pere Gines; Patrick S Kamath; Douglas A Simonetto; Tony Y Hu; Vijay H Shah; Harmeet Malhi
Journal:  Hepatology       Date:  2020-10-30       Impact factor: 17.425

10.  A Novel Mouse Model of Acute-on-Chronic Cholestatic Alcoholic Liver Disease: A Systems Biology Comparison With Human Alcoholic Hepatitis.

Authors:  Shinji Furuya; Josepmaria Argemi; Takeki Uehara; Yuuki Katou; Derrick E Fouts; Bernd Schnabl; Laurent Dubuquoy; Abha Belorkar; Rajanikanth Vadigepalli; Hiroshi Kono; Ramon Bataller; Ivan Rusyn
Journal:  Alcohol Clin Exp Res       Date:  2019-11-28       Impact factor: 3.928

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