Literature DB >> 30644100

Therapeutics for advanced hepatocellular carcinoma: Recent advances, current dilemma, and future directions.

Jing Zhu1, Tailang Yin2, Yong Xu3, Xiao-Jie Lu1.   

Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignancies and is a serious threat to people's health worldwide. The prognosis of advanced HCC is dim if left untreated. In the clinic, the treatment options for advanced HCC include surgery, radiotherapy, transcatheter arterial chemoembolization, and so forth. In recent years, molecular targeted therapy and immunotherapy have also made great progress, bringing new hope to patients with advanced HCC. In this study, therapeutic advances, current dilemma, and future directions of advanced HCC are reviewed, which might serve as a summary for clinicians and may stimulate future research.
© 2019 Wiley Periodicals, Inc.

Entities:  

Keywords:  Hepatocellular carcinoma (HCC); portal vein tumor thrombosis; transcatheter arterial chemoembolization: immunotherapy

Mesh:

Substances:

Year:  2019        PMID: 30644100     DOI: 10.1002/jcp.28048

Source DB:  PubMed          Journal:  J Cell Physiol        ISSN: 0021-9541            Impact factor:   6.384


  21 in total

1.  Prognostic Significance of Preoperative Integrated Liver Inflammatory Score in Patients with Hepatocellular Carcinoma.

Authors:  Biao Wu; Yumeng Wu; Xianlin Guo; Yifei Liu; Yanping Yue; Wenjing Zhao; Jibin Liu; Xuming Wu; Aiguo Shen; Suqing Zhang
Journal:  Med Sci Monit       Date:  2022-06-21

2.  Clinical significance of the immune cell landscape in hepatocellular carcinoma patients with different degrees of fibrosis.

Authors:  Xiaofeng Tang; Zheyue Shu; Weichen Zhang; Longyu Cheng; Jun Yu; Min Zhang; Shusen Zheng
Journal:  Ann Transl Med       Date:  2019-10

3.  An Individualized Immune Prognostic Index is a Superior Predictor of Survival of Hepatocellular Carcinoma.

Authors:  Xiaodong Wang; Yuquan Wu; Dongyue Wen; Lin-Yong Wu; Yujia Zhao; Yun He; Hong Yang
Journal:  Med Sci Monit       Date:  2020-05-31

4.  Intratumoral IL-12 Gene Therapy Inhibits Tumor Growth In A HCC-Hu-PBL-NOD/SCID Murine Model.

Authors:  Zhi-Feng Zhou; Feng Peng; Jie-Yu Li; Yun-Bin Ye
Journal:  Onco Targets Ther       Date:  2019-09-20       Impact factor: 4.147

Review 5.  Anti-tumoral activity of single and combined regorafenib treatments in preclinical models of liver and gastrointestinal cancers.

Authors:  Flavia Fondevila; Carolina Méndez-Blanco; Paula Fernández-Palanca; Javier González-Gallego; José L Mauriz
Journal:  Exp Mol Med       Date:  2019-09-24       Impact factor: 8.718

6.  Efficacy and safety of Chinese patent medicine (Jinlong capsule) in the treatment of advanced hepatocellular carcinoma: a meta-analysis.

Authors:  He Xu; Wenjie Wei; Mu Y; Chengwei Dong
Journal:  Biosci Rep       Date:  2020-01-31       Impact factor: 3.840

7.  Exosomal miR-638 Inhibits Hepatocellular Carcinoma Progression by Targeting SP1.

Authors:  Jing Yang; Bo Li; Shuo Zhao; Hongyu Du; Yaming Du
Journal:  Onco Targets Ther       Date:  2020-07-07       Impact factor: 4.147

8.  Big Data-Based Identification of Multi-Gene Prognostic Signatures in Liver Cancer.

Authors:  Meiliang Liu; Xia Liu; Shun Liu; Feifei Xiao; Erna Guo; Xiaoling Qin; Liuyu Wu; Qiuli Liang; Zerui Liang; Kehua Li; Di Zhang; Yu Yang; Xingxi Luo; Lei Lei; Jennifer Hui Juan Tan; Fuqiang Yin; Xiaoyun Zeng
Journal:  Front Oncol       Date:  2020-05-28       Impact factor: 6.244

Review 9.  Modulation of the Autophagy-lysosomal Pathway in Hepatocellular Carcinoma Using Small Molecules.

Authors:  Yu Geon Lee; Tae-Il Jeon
Journal:  Molecules       Date:  2020-03-30       Impact factor: 4.411

10.  Effect of sodium cantharidinate/vitamin B6 injection on survival, liver function, immune function, and quality of life in patients with hepatocellular carcinoma: Protocol for a meta-analysis.

Authors:  Min Zhu; Xiujing Liu; Changhui Zhou; Juan Li
Journal:  Medicine (Baltimore)       Date:  2020-08-21       Impact factor: 1.817

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