Literature DB >> 30642938

Clofazimine Exposure In Vitro Selects Efflux Pump Mutants and Bedaquiline Resistance.

Nabila Ismail1, Remco P H Peters2,3, Nazir A Ismail2,4,5, Shaheed V Omar5.   

Abstract

Six in vitro clofazimine-resistant spontaneous mutants obtained from a wild-type or pyrazinamide-resistant ATCC reference strain were selected to evaluate bedaquiline cross-resistance. The reverse was conducted for bedaquiline mutants. All clofazimine mutants harboring an rv0678 mutation displayed phenotypic cross-resistance. We observed the same for rv0678 bedaquiline mutants; however, atpE bedaquiline mutants showed no phenotypic cross-resistance. This confirms that upfront clofazimine usage may impact subsequent bedaquiline use due to a shared efflux resistance pathway.
Copyright © 2019 American Society for Microbiology.

Entities:  

Keywords:  bedaquiline; clofazimine; cross-resistance; efflux pump mutants

Mesh：

Substances：

Year:  2019        PMID： 30642938      PMCID： PMC6395909          DOI： 10.1128/AAC.02141-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

1.  A Multimethod, Multicountry Evaluation of Breakpoints for Bedaquiline Resistance Determination.

Authors:  Koné Kaniga; Shaheed V Omar; Nazir Ahmed Ismail; Akio Aono; Emanuele Borroni; Daniela Maria Cirillo; Christel Desmaretz; Rumina Hasan; Satoshi Mitarai; Sadia Shakoor; Gabriela Torrea
Journal:  Antimicrob Agents Chemother       Date:  2020-08-20       Impact factor: 5.191

2.  Systematic review of mutations associated with resistance to the new and repurposed Mycobacterium tuberculosis drugs bedaquiline, clofazimine, linezolid, delamanid and pretomanid.

Authors:  Suha Kadura; Nicholas King; Maria Nakhoul; Hongya Zhu; Grant Theron; Claudio U Köser; Maha Farhat
Journal:  J Antimicrob Chemother       Date:  2020-08-01       Impact factor: 5.790

3.  In Vitro Susceptibility of Nocardia farcinica to the Antimycobacterial Drug Clofazimine.

Authors:  Ka Lip Chew; Sophie Octavia; Siang Fei Yeoh; Jeanette W P Teo
Journal:  Antimicrob Agents Chemother       Date:  2020-12-16       Impact factor: 5.191

4.  Population-level emergence of bedaquiline and clofazimine resistance-associated variants among patients with drug-resistant tuberculosis in southern Africa: a phenotypic and phylogenetic analysis.

Authors:  Camus Nimmo; James Millard; Lucy van Dorp; Kayleen Brien; Sashen Moodley; Allison Wolf; Alison D Grant; Nesri Padayatchi; Alexander S Pym; François Balloux; Max O'Donnell
Journal:  Lancet Microbe       Date:  2020-08

5.  Bedaquiline Drug Resistance Emergence Assessment in Multidrug-Resistant Tuberculosis (MDR-TB): a 5-Year Prospective In Vitro Surveillance Study of Bedaquiline and Other Second-Line Drug Susceptibility Testing in MDR-TB Isolates.

Authors:  Koné Kaniga; Rumina Hasan; Ruwen Jou; Edita Vasiliauskienė; Charoen Chuchottaworn; Nazir Ismail; Beverly Metchock; Skaidrius Miliauskas; Nguyen Viet Nhung; Camilla Rodrigues; Soyoun Shin; Hulya Simsek; Saijai Smithtikarn; Anh Le Thi Ngoc; Jirakan Boonyasopun; Mubin Kazi; Seungmo Kim; Phalin Kamolwat; Greta Musteikiene; Catherine Ann Sacopon; Sabira Tahseen; Laima Vasiliauskaitė; Mei-Hua Wu; Shaheed Vally Omar
Journal:  J Clin Microbiol       Date:  2021-10-27       Impact factor: 11.677

6.  Genetic variants and their association with phenotypic resistance to bedaquiline in Mycobacterium tuberculosis: a systematic review and individual isolate data analysis.

Authors:  Nabila Ismail; Emmanuel Rivière; Jason Limberis; Stella Huo; John Z Metcalfe; Rob M Warren; Annelies Van Rie
Journal:  Lancet Microbe       Date:  2021-08-31

7.  Variants associated with Bedaquiline (BDQ) resistance identified in Rv0678 and efflux pump genes in Mycobacterium tuberculosis isolates from BDQ naïve TB patients in Pakistan.

Authors:  Sadia Shakoor; Safina Abdul Razzak; Dania Khalid Saeed; Zahra Hasan; Saba Faraz Sabzwari; Zahida Azizullah; Akbar Kanji; Asghar Nasir; Samreen Shafiq; Najia Karim Ghanchi; Rumina Hasan
Journal:  BMC Microbiol       Date:  2022-02-25       Impact factor: 3.605

Review 8.  Application of Next Generation Sequencing for Diagnosis and Clinical Management of Drug-Resistant Tuberculosis: Updates on Recent Developments in the Field.

Authors:  Navisha Dookie; Azraa Khan; Nesri Padayatchi; Kogieleum Naidoo
Journal:  Front Microbiol       Date:  2022-03-24       Impact factor: 5.640

Review 9.  Whole Genome Sequencing for the Analysis of Drug Resistant Strains of Mycobacterium tuberculosis: A Systematic Review for Bedaquiline and Delamanid.

Authors:  Luisa Maria Nieto Ramirez; Karina Quintero Vargas; Gustavo Diaz
Journal:  Antibiotics (Basel)       Date:  2020-03-23

10.  Resistance against Membrane-Inserting MmpL3 Inhibitor through Upregulation of MmpL5 in Mycobacterium tuberculosis.

Authors:  Ming Li; Samuel Agyei Nyantakyi; Mei-Lin Go; Thomas Dick
Journal:  Antimicrob Agents Chemother       Date:  2020-11-17       Impact factor: 5.191
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