Literature DB >> 30642914

No Cell Left Unturned: Intraductal Papillary Mucinous Neoplasm Heterogeneity.

Yasmin G Hernandez-Barco1,2, Nabeel Bardeesy1, David T Ting3.   

Abstract

Intraductal papillary mucinous neoplasm (IPMN) is a pancreatic cancer precursor lesion with established genetic features, but the cellular ecosystem of these tumors remains to be fully characterized. This study utilizes single-cell RNA sequencing to describe the dynamic landscape of epithelial, immune, and stromal cells during IPMN progression to invasive cancer.See related article by Bernard et al., p. 2194. ©2019 American Association for Cancer Research.

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Year:  2019        PMID： 30642914      PMCID： PMC6445728          DOI： 10.1158/1078-0432.CCR-18-3877

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   12.531


  5 in total

1.  γδ T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation.

Authors:  Donnele Daley; Constantinos Pantelis Zambirinis; Lena Seifert; Neha Akkad; Navyatha Mohan; Gregor Werba; Rocky Barilla; Alejandro Torres-Hernandez; Mautin Hundeyin; Vishnu Raj Kumar Mani; Antonina Avanzi; Daniel Tippens; Rajkishen Narayanan; Jung-Eun Jang; Elliot Newman; Venu Gopal Pillarisetty; Michael Loran Dustin; Dafna Bar-Sagi; Cristina Hajdu; George Miller
Journal:  Cell       Date:  2016-08-25       Impact factor: 41.582

2.  Single-Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression.

Authors:  Vincent Bernard; Alexander Semaan; Jonathan Huang; F Anthony San Lucas; Feven C Mulu; Bret M Stephens; Paola A Guerrero; Yanqing Huang; Jun Zhao; Nabiollah Kamyabi; Subrata Sen; Paul A Scheet; Cullen M Taniguchi; Michael P Kim; Ching-Wei Tzeng; Matthew H Katz; Aatur D Singhi; Anirban Maitra; Hector A Alvarez
Journal:  Clin Cancer Res       Date:  2018-11-01       Impact factor: 12.531

3.  Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer.

Authors:  Daniel Öhlund; Abram Handly-Santana; Giulia Biffi; Ela Elyada; Ana S Almeida; Mariano Ponz-Sarvise; Vincenzo Corbo; Tobiloba E Oni; Stephen A Hearn; Eun Jung Lee; Iok In Christine Chio; Chang-Il Hwang; Hervé Tiriac; Lindsey A Baker; Dannielle D Engle; Christine Feig; Anne Kultti; Mikala Egeblad; Douglas T Fearon; James M Crawford; Hans Clevers; Youngkyu Park; David A Tuveson
Journal:  J Exp Med       Date:  2017-02-23       Impact factor: 14.307

4.  Crosstalk between Regulatory T Cells and Tumor-Associated Dendritic Cells Negates Anti-tumor Immunity in Pancreatic Cancer.

Authors:  Jung-Eun Jang; Cristina H Hajdu; Caroline Liot; George Miller; Michael L Dustin; Dafna Bar-Sagi
Journal:  Cell Rep       Date:  2017-07-18       Impact factor: 9.423

5.  Single-cell RNA sequencing identifies extracellular matrix gene expression by pancreatic circulating tumor cells.

Authors:  David T Ting; Ben S Wittner; Matteo Ligorio; Nicole Vincent Jordan; Ajay M Shah; David T Miyamoto; Nicola Aceto; Francesca Bersani; Brian W Brannigan; Kristina Xega; Jordan C Ciciliano; Huili Zhu; Olivia C MacKenzie; Julie Trautwein; Kshitij S Arora; Mohammad Shahid; Haley L Ellis; Na Qu; Nabeel Bardeesy; Miguel N Rivera; Vikram Deshpande; Cristina R Ferrone; Ravi Kapur; Sridhar Ramaswamy; Toshi Shioda; Mehmet Toner; Shyamala Maheswaran; Daniel A Haber
Journal:  Cell Rep       Date:  2014-09-18       Impact factor: 9.423
  5 in total
  3 in total

1.  Diminished Immune Surveillance during Histologic Progression of Intraductal Papillary Mucinous Neoplasms Offers a Therapeutic Opportunity for Cancer Interception.

Authors:  Sharia Hernandez; Edwin Roger Parra; Luisa M Solis; Subrata Sen; Naohiro Uraoka; Ximing Tang; Yu Shen; Wei Qiao; Mei Jiang; Shanyu Zhang; Barbara Mino; Wei Lu; Renganayaki Pandurengan; Cara Haymaker; Kajsa Affolter; Courtney L Scaife; Michele Yip-Schneider; C Max Schmidt; Matthew A Firpo; Sean J Mulvihill; Eugene J Koay; Huamin Wang; Ignacio I Wistuba; Anirban Maitra
Journal:  Clin Cancer Res       Date:  2022-05-02       Impact factor: 13.801

2.  Symphony in chaos: Immune orchestra during pancreatic cancer progression.

Authors:  Prateek Sharma; Tejeshwar Jain; Vrishketan Sethi; Vikas Dudeja
Journal:  EBioMedicine       Date:  2020-05-23       Impact factor: 8.143

Review 3.  Observation or resection of pancreatic intraductal papillary mucinous neoplasm: An ongoing tug of war.

Authors:  Jan Rune Aunan; Nigel B Jamieson; Kjetil Søreide
Journal:  World J Gastrointest Oncol       Date:  2019-12-15
  3 in total

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