Michael A Campitelli1, Colleen J Maxwell1, Laura C Maclagan1, Dennis T Ko1, Chaim M Bell1, Lianne Jeffs1, Andrew M Morris1, Kate L Lapane1, Nick Daneman1, Susan E Bronskill2. 1. ICES (Campitelli, Maxwell, Maclagan, Ko, Bell, Daneman, Bronskill); Sunnybrook Research Institute (Ko, Daneman, Bronskill), Department of Cardiology (Ko) and Division of Infectious Diseases (Daneman), Sunnybrook Health Sciences Centre; Department of Medicine (Ko, Bell, Morris, Daneman) and Institute of Health Policy, Management and Evaluation (Ko, Jeffs, Daneman, Bronskill), University of Toronto; Lawrence S. Bloomberg Faculty of Nursing (Jeffs), University of Toronto; Division of General Internal Medicine (Bell), Mount Sinai Health System; Women's College Research Institute (Bronskill), Women's College Hospital; Keenan Research Centre at the Li Ka Shing Knowledge Institute (Jeffs), St. Michael's Hospital, Toronto, Ont.; Schools of Pharmacy (Maxwell) and Public Health and Health Systems (Maxwell), University of Waterloo, Waterloo, Ont.; Department of Quantitative Health Sciences (Lapane), University of Massachusetts Medical School, Worchester, Mass. 2. ICES (Campitelli, Maxwell, Maclagan, Ko, Bell, Daneman, Bronskill); Sunnybrook Research Institute (Ko, Daneman, Bronskill), Department of Cardiology (Ko) and Division of Infectious Diseases (Daneman), Sunnybrook Health Sciences Centre; Department of Medicine (Ko, Bell, Morris, Daneman) and Institute of Health Policy, Management and Evaluation (Ko, Jeffs, Daneman, Bronskill), University of Toronto; Lawrence S. Bloomberg Faculty of Nursing (Jeffs), University of Toronto; Division of General Internal Medicine (Bell), Mount Sinai Health System; Women's College Research Institute (Bronskill), Women's College Hospital; Keenan Research Centre at the Li Ka Shing Knowledge Institute (Jeffs), St. Michael's Hospital, Toronto, Ont.; Schools of Pharmacy (Maxwell) and Public Health and Health Systems (Maxwell), University of Waterloo, Waterloo, Ont.; Department of Quantitative Health Sciences (Lapane), University of Massachusetts Medical School, Worchester, Mass. susan.bronskill@ices.on.ca.
Abstract
BACKGROUND: Guidance from randomized clinical trials about the ongoing benefits of statin therapies in residents of long-term care facilities is lacking. We sought to examine the effect of statin dose on 1-year survival and admission to hospital for cardiovascular events in this setting. METHODS: We conducted a retrospective cohort study using population-based administrative data from Ontario, Canada. We identified 21 808 residents in long-term care facilities who were 76 years of age and older and were prevalent statin users on the date of a full clinical assessment between April 2013 and March 2014, and categorized residents as intensive- or moderate-dose users. Treatment groups were matched on age, sex, admission to hospital for atherosclerotic cardiovascular disease, resident frailty and propensity score. Differences in 1-year survival and admission to hospital for cardiovascular events were measured using Cox proportional and subdistribution hazard models, respectively. RESULTS: Using propensity-score matching, we included 4577 well-balanced pairs of residents who were taking intensive- and moderate-dose statins. After 1 year, there were 1210 (26.4%) deaths and 524 (11.5%) admissions to hospital for cardiovascular events among residents using moderate-dose statins compared with 1173 (25.6%) deaths and 522 (11.4%) admissions to hospital for cardiovascular events among those taking intensive-dose statins. We found no significant association between prevalent use of intensive-dose statins and 1-year survival (hazard ratio [HR] 0.97, 95% confidence interval [CI] 0.90 to 1.05) or 1-year admission to hospital for cardiovascular events (HR 0.99, 95% CI 0.88 to 1.12) compared with use of moderate-dose statins. INTERPRETATION: The rates of mortality and admission to hospital for cardiovascular events at 1 year were similar between residents in long-term care taking intensive-dose statins compared with those taking moderate-dose statins. This lack of benefit should be considered when prescribing statins to vulnerable residents of long-term care facilities who are at potentially increased risk of statin-related adverse events.
BACKGROUND: Guidance from randomized clinical trials about the ongoing benefits of statin therapies in residents of long-term care facilities is lacking. We sought to examine the effect of statin dose on 1-year survival and admission to hospital for cardiovascular events in this setting. METHODS: We conducted a retrospective cohort study using population-based administrative data from Ontario, Canada. We identified 21 808 residents in long-term care facilities who were 76 years of age and older and were prevalent statin users on the date of a full clinical assessment between April 2013 and March 2014, and categorized residents as intensive- or moderate-dose users. Treatment groups were matched on age, sex, admission to hospital for atherosclerotic cardiovascular disease, resident frailty and propensity score. Differences in 1-year survival and admission to hospital for cardiovascular events were measured using Cox proportional and subdistribution hazard models, respectively. RESULTS: Using propensity-score matching, we included 4577 well-balanced pairs of residents who were taking intensive- and moderate-dose statins. After 1 year, there were 1210 (26.4%) deaths and 524 (11.5%) admissions to hospital for cardiovascular events among residents using moderate-dose statins compared with 1173 (25.6%) deaths and 522 (11.4%) admissions to hospital for cardiovascular events among those taking intensive-dose statins. We found no significant association between prevalent use of intensive-dose statins and 1-year survival (hazard ratio [HR] 0.97, 95% confidence interval [CI] 0.90 to 1.05) or 1-year admission to hospital for cardiovascular events (HR 0.99, 95% CI 0.88 to 1.12) compared with use of moderate-dose statins. INTERPRETATION: The rates of mortality and admission to hospital for cardiovascular events at 1 year were similar between residents in long-term care taking intensive-dose statins compared with those taking moderate-dose statins. This lack of benefit should be considered when prescribing statins to vulnerable residents of long-term care facilities who are at potentially increased risk of statin-related adverse events.
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