Zahra Mazloum Khorasani1, Ramin Khameneh Bagheri2, Mohammad Ali Yaghoubi3, Saeed Chobkar4, Monavvar Afzal Aghaee5, Mohammad Reza Abbaszadegan6, Amirhossein Sahebkar7. 1. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. 2. Department of Cardiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. 3. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Birjand University of Medical Sciences, Birjand, Iran. 4. School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: chobkar.saeed@gmail.com. 5. Department of Social Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. 6. Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. 7. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Abstract
BACKGROUND: Cardiovascular disease is the most common cause of mortality and morbidity in diabetic patients. Insulin resistance has been shown to be reduced by the secretion of irisin from muscle and adipose tissues. This study was aimed at determining the relationship between serum irisin levels and angiographically defined coronary artery disease (CAD) in type II diabetic patients. METHODS: In this case-control study, 30 diabetic subjects with angiographically defined CAD were compared with 30 age- and sex-matched diabetic subjects without CAD in terms of clinical and laboratory parameters including serum irisin levels. RESULTS: Serum levels of Irisin were significantly higher in the diabetic group without CAD compared with the group with CAD (P = 0.048). Serum irisin levels showed a significant positive correlation with BMI (r = 0.374, P = 0.004) and fasting insulin (r = 0.303, P = 0.021), and a significant negative correlation with diabetes duration (r = -0.384, P = 0.002). Based on the results of the binary logistic regression model, circulating levels of irisin were associated with the presence of CAD in diabetes (p = 0.038) after adjusting for potential confounders. CONCLUSION: Serum irisin levels were lower in the diabetic patients with cardiovascular complication compared with the uncomplicated diabetic patients. Therefore, additional larger scale studies are needed to determine the role of irisin in monitoring CAD in diabetic patients.
BACKGROUND:Cardiovascular disease is the most common cause of mortality and morbidity in diabeticpatients. Insulin resistance has been shown to be reduced by the secretion of irisin from muscle and adipose tissues. This study was aimed at determining the relationship between serum irisin levels and angiographically defined coronary artery disease (CAD) in type II diabeticpatients. METHODS: In this case-control study, 30 diabetic subjects with angiographically defined CAD were compared with 30 age- and sex-matched diabetic subjects without CAD in terms of clinical and laboratory parameters including serum irisin levels. RESULTS: Serum levels of Irisin were significantly higher in the diabetic group without CAD compared with the group with CAD (P = 0.048). Serum irisin levels showed a significant positive correlation with BMI (r = 0.374, P = 0.004) and fasting insulin (r = 0.303, P = 0.021), and a significant negative correlation with diabetes duration (r = -0.384, P = 0.002). Based on the results of the binary logistic regression model, circulating levels of irisin were associated with the presence of CAD in diabetes (p = 0.038) after adjusting for potential confounders. CONCLUSION: Serum irisin levels were lower in the diabeticpatients with cardiovascular complication compared with the uncomplicated diabeticpatients. Therefore, additional larger scale studies are needed to determine the role of irisin in monitoring CAD in diabeticpatients.
Authors: Yani Wang; Huibin Liu; Na Sun; Jing Li; Xiang Peng; Ying Jia; Jason Karch; Bo Yu; Xander H T Wehrens; Jinwei Tian Journal: Oxid Med Cell Longev Date: 2021-10-29 Impact factor: 6.543
Authors: Dae Yun Seo; Jun Hyun Bae; Tae Nyun Kim; Hyo-Bum Kwak; Pham Trong Kha; Jin Han Journal: Int J Environ Res Public Health Date: 2020-05-29 Impact factor: 3.390