Michael C Riddell1, Rubin Pooni2, Loren Yavelberg3, Zoey Li4, Craig Kollman5, Ruth E Brown6, Aihua Li7, Ronnie Aronson8. 1. LMC Diabetes and Endocrinology, 1929 Bayview Ave., Toronto, Ontario, Canada; School of Kinesiology and Health Science, York University, 4700 Keele St., Toronto, Ontario, Canada. Electronic address: Michael.riddell@lmc.ca. 2. School of Kinesiology and Health Science, York University, 4700 Keele St., Toronto, Ontario, Canada. Electronic address: rubinp@my.yorku.ca. 3. School of Kinesiology and Health Science, York University, 4700 Keele St., Toronto, Ontario, Canada. Electronic address: loreny@yorku.ca. 4. JAEB Center for Health Research, 15310 Amberly Dr., Tampa, FL, USA. Electronic address: zli@jaeb.org. 5. JAEB Center for Health Research, 15310 Amberly Dr., Tampa, FL, USA. Electronic address: ckollman@jaeb.org. 6. LMC Diabetes and Endocrinology, 1929 Bayview Ave., Toronto, Ontario, Canada. Electronic address: ruth.brown@lmc.ca. 7. LMC Diabetes and Endocrinology, 1929 Bayview Ave., Toronto, Ontario, Canada. Electronic address: Aihua.li@lmc.ca. 8. LMC Diabetes and Endocrinology, 1929 Bayview Ave., Toronto, Ontario, Canada. Electronic address: Ronnie.aronson@lmc.ca.
Abstract
AIMS: Patients with type 1 diabetes (T1D) often report a rise in their blood glucose level following brief intense exercise. We sought to determine the reproducibility of the cardiometabolic responses to high-intensity interval training (HIIT). METHODS: Sixteen adults with T1D, using an optimized multiple daily injection with basal insulin glargine 300 U/mL (Gla-300), performed four fasted HIIT sessions over a 4-6-week period. Exercise consisted of high-intensity interval cycling and multimodal training over 25 min. RESULTS: Heart rate and rating of perceived exertion rose similarly in all sessions, as did lactate, catecholamine and growth hormone levels. Plasma glucose increased in response to HIIT in 62 of 64 visits (97%), with an overall increase of 3.7 ± 1.6 mmol/L (Mean ± SD) (P < 0.001). In within-patient comparisons, the change in plasma glucose among the four HIIT sessions was significantly correlated with a composite correlation of 0.58 ([r2 = 0.34]; 95% CI 0.35-0.80; P < 0.01). CONCLUSIONS: Intersession observations of four separate HIIT sessions showed high intrasubject reproducibility in the cardiometabolic responses to exercise, including the rise in plasma glucose, when adults with T1D perform the activity in a fasted state.
AIMS: Patients with type 1 diabetes (T1D) often report a rise in their blood glucose level following brief intense exercise. We sought to determine the reproducibility of the cardiometabolic responses to high-intensity interval training (HIIT). METHODS: Sixteen adults with T1D, using an optimized multiple daily injection with basal insulin glargine 300 U/mL (Gla-300), performed four fasted HIIT sessions over a 4-6-week period. Exercise consisted of high-intensity interval cycling and multimodal training over 25 min. RESULTS: Heart rate and rating of perceived exertion rose similarly in all sessions, as did lactate, catecholamine and growth hormone levels. Plasma glucose increased in response to HIIT in 62 of 64 visits (97%), with an overall increase of 3.7 ± 1.6 mmol/L (Mean ± SD) (P < 0.001). In within-patient comparisons, the change in plasma glucose among the four HIIT sessions was significantly correlated with a composite correlation of 0.58 ([r2 = 0.34]; 95% CI 0.35-0.80; P < 0.01). CONCLUSIONS: Intersession observations of four separate HIIT sessions showed high intrasubject reproducibility in the cardiometabolic responses to exercise, including the rise in plasma glucose, when adults with T1D perform the activity in a fasted state.
Authors: Sam N Scott; Lorraine Anderson; James P Morton; Anton J M Wagenmakers; Michael C Riddell Journal: Nutrients Date: 2019-05-07 Impact factor: 5.717
Authors: Othmar Moser; Michael C Riddell; Max L Eckstein; Peter Adolfsson; Rémi Rabasa-Lhoret; Louisa van den Boom; Pieter Gillard; Kirsten Nørgaard; Nick S Oliver; Dessi P Zaharieva; Tadej Battelino; Carine de Beaufort; Richard M Bergenstal; Bruce Buckingham; Eda Cengiz; Asma Deeb; Tim Heise; Simon Heller; Aaron J Kowalski; Lalantha Leelarathna; Chantal Mathieu; Christoph Stettler; Martin Tauschmann; Hood Thabit; Emma G Wilmot; Harald Sourij; Carmel E Smart; Peter G Jacobs; Richard M Bracken; Julia K Mader Journal: Pediatr Diabetes Date: 2020-10-13 Impact factor: 4.866