Literature DB >> 30640477

Isopenicins A-C: Two Types of Antitumor Meroterpenoids from the Plant Endophytic Fungus Penicillium sp. sh18.

Jian-Wei Tang1,2, Ling-Mei Kong1, Wen-Yu Zu3, Kun Hu1, Xiao-Nian Li1, Bing-Chao Yan1, Wei-Guang Wang1, Han-Dong Sun1, Yan Li1, Pema-Tenzin Puno1.   

Abstract

Isopenicins A-C (1-3), three novel meroterpenoids possessing two types of unprecedented terpenoid-polyketide hybrid skeletons, were isolated from the cultures of Penicillium sp. sh18. Their structures were determined through synergetic use of extensive spectroscopic analysis, quantum-chemical calculation with ANN-PRA analysis, and X-ray crystallographic analysis. Additionally, the inhibitory activities of these compounds on the Wnt/β-catenin signaling pathway were evaluated, and 1 was identified as a potent inhibitor of the Wnt signaling pathway.

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Year:  2019        PMID： 30640477     DOI： 10.1021/acs.orglett.8b04020

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  11 in total

Review 1.  Endophytic Penicillium species and their agricultural, biotechnological, and pharmaceutical applications.

Authors:  Rufin Marie Kouipou Toghueo; Fabrice Fekam Boyom
Journal:  3 Biotech       Date:  2020-02-08       Impact factor: 2.406

2.  Classification of Aspergillus, Penicillium, Talaromyces and related genera (Eurotiales): An overview of families, genera, subgenera, sections, series and species.

Authors:  J Houbraken; S Kocsubé; C M Visagie; N Yilmaz; X-C Wang; M Meijer; B Kraak; V Hubka; K Bensch; R A Samson; J C Frisvad
Journal:  Stud Mycol       Date:  2020-06-27       Impact factor: 16.097

3.  Characterization of a bioactive meroterpenoid isolated from the marine-derived fungus Talaromyces sp.

Authors:  Xuan Hong; Xiaoqing Guan; Qiliang Lai; Dehua Yu; Zhongwei Chen; Xiaoteng Fu; Beibei Zhang; Changkun Chen; Zongze Shao; Jinmei Xia; Jiang-Jiang Qin; Weiyi Wang
Journal:  Appl Microbiol Biotechnol       Date:  2022-04-13       Impact factor: 4.813

Review 4.  Biological activities of meroterpenoids isolated from different sources.

Authors:  Neeraj Kumar Fuloria; Radhika K Raheja; Kaushal H Shah; Manisha J Oza; Yogesh A Kulkarni; Vetriselvan Subramaniyan; Mahendran Sekar; Shivkanya Fuloria
Journal:  Front Pharmacol       Date:  2022-09-19       Impact factor: 5.988

5.  Cytochalasans from the Endophytic Fungus Phomopsis sp. shj2 and Their Antimigratory Activities.

Authors:  Bing-Chao Yan; Wei-Guang Wang; Ling-Mei Kong; Jian-Wei Tang; Xue Du; Yan Li; Pema-Tenzin Puno
Journal:  J Fungi (Basel)       Date:  2022-05-23

Review 6.  Small Molecule Wnt Pathway Modulators from Natural Sources: History, State of the Art and Perspectives.

Authors:  Artem Blagodatski; Antonina Klimenko; Lee Jia; Vladimir L Katanaev
Journal:  Cells       Date:  2020-03-02       Impact factor: 6.600

7.  Andrastone A From the Deep-Sea-Derived Fungus Penicillium allii-sativi Acts as an Inducer of Caspase and RXRα-Dependent Apoptosis.

Authors:  Chun-Lan Xie; Jin-Mei Xia; Ting Lin; Ying-Jie Lin; Yu-Kun Lin; Man-Li Xia; Hai-Feng Chen; Zhu-Hua Luo; Zong-Ze Shao; Xian-Wen Yang
Journal:  Front Chem       Date:  2019-10-30       Impact factor: 5.221

8.  Endophytic fungi: A treasure trove of novel anticancer compounds.

Authors:  Jignesh Prajapati; Dweipayan Goswami; Rakesh M Rawal
Journal:  Curr Res Pharmacol Drug Discov       Date:  2021-09-01

Review 9.  Endophytic Fungal Terpenoids: Natural Role and Bioactivities.

Authors:  Juan M Galindo-Solís; Francisco J Fernández
Journal:  Microorganisms       Date:  2022-02-01

10.  Four New Insecticidal Xanthene Derivatives from the Mangrove-Derived Fungus Penicillium sp. JY246.

Authors:  Meng Bai; Cai-Juan Zheng; Xu-Hua Nong; Xue-Ming Zhou; You-Ping Luo; Guang-Ying Chen
Journal:  Mar Drugs       Date:  2019-11-20       Impact factor: 5.118
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