Literature DB >> 30640

The effects of HGCl2 and mersalyl on mechanisms regulating intracellular calcium and transmitter release.

O Binah, U Meiri, H Rahamimoff.   

Abstract

HgCl2 and mersalyl increased and later decreased both the spontaneous and evoked transmitter liberation at the frog neuromuscular junction. Lower concentration of HgCl2 exhibited only an inhibitory effect on transmitter release. These mercurials inhibited calcium transport of mitochondria and synaptosomal vesicles. Lower concentrations of HgCl2 showed a stimulatory effect on mitochondrial calcium uptake. It is suggested that the effect of mercurials on transmitter release is mediated via changes of the intracellular calcium ion concentration.

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Year:  1978        PMID： 30640     DOI： 10.1016/0014-2999(78)90438-7

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

Review 1.  Effects of toxic environmental contaminants on voltage-gated calcium channel function: from past to present.

Authors:  William D Atchison
Journal:  J Bioenerg Biomembr       Date:  2003-12       Impact factor: 2.945

2.  Muscle damage induced by the ionophore A23187 can be prevented by prostaglandin inhibitors and leupeptin.

Authors:  F T Llados
Journal:  Experientia       Date:  1985-12-15

3.  Ebselen protects Ca2+ influx blockage but does not protect glutamate uptake inhibition caused by Hg2+.

Authors:  M B Moretto; J Franco; T Posser; C W Nogueira; G Zeni; J B T Rocha
Journal:  Neurochem Res       Date:  2004-10       Impact factor: 3.996

4.  Effects of inorganic mercury (Hg2+) on calcium channel currents and catecholamine release from bovine chromaffin cells.

Authors:  F Weinsberg; U Bickmeyer; H Wiegand
Journal:  Arch Toxicol       Date:  1995       Impact factor: 5.153

5.  Lanthanum as a surrogate for calcium in transmitter release at mouse motor nerve terminals.

Authors:  M J Curtis; D M Quastel; D A Saint
Journal:  J Physiol       Date:  1986-04       Impact factor: 5.182

6.  Beta-bungarotoxin stimulates the synthesis and accumulation of acetylcholine in rat phrenic nerve diaphragm preparations.

Authors:  C B Gundersen; D J Jenden; M W Newton
Journal:  J Physiol       Date:  1981-01       Impact factor: 5.182
  6 in total

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