Literature DB >> 30639304

Advice on assistance and protection provided by the Scientific Advisory Board of the Organisation for the Prohibition of Chemical Weapons: Part 1. On medical care and treatment of injuries from nerve agents.

Christopher M Timperley1, Jonathan E Forman2, Mohammad Abdollahi3, Abdullah Saeed Al-Amri4, Augustin Baulig5, Djafer Benachour6, Veronica Borrett7, Flerida A Cariño8, Michael Geist9, David Gonzalez10, William Kane11, Zrinka Kovarik12, Roberto Martínez-Álvarez13, Nicia Maria Fusaro Mourão14, Slawomir Neffe15, Syed K Raza16, Valentin Rubaylo17, Alejandra Graciela Suárez18, Koji Takeuchi19, Cheng Tang20, Ferruccio Trifirò21, Francois Mauritz van Straten22, Paula S Vanninen23, Slavica Vučinić24, Volodymyr Zaitsev25, Muhammad Zafar-Uz-Zaman26, Mongia Saïd Zina27, Stian Holen28.   

Abstract

The Scientific Advisory Board (SAB) of the Organisation for the Prohibition of Chemical Weapons (OPCW) has provided advice on assistance and protection in relation to the Chemical Weapons Convention. In this, the first of several papers describing the SAB's work on this topic, we describe advice given in response to questions from the OPCW Director-General in 2013 and 2014 on the status of available medical countermeasures and treatments to organophosphorus nerve agents. This paper provides the evidence base for this advice which recommended to the OPCW pretreatments, emergency care, and long-term treatments that were available at the time of the request for this class of chemical warfare agent (CWA). It includes a bibliography of over 140 scientific references, which can be used as a platform for watching future medical countermeasure developments. The information provided in this paper should serve as a valuable reference for medical professionals and emergency responders who may have no knowledge of the symptoms and treatment options of exposure to nerve agents.
Copyright © 2019. Published by Elsevier B.V.

Entities:  

Keywords:  Assistance and protection against chemical weapons; Chemical Weapons Convention; Chemical warfare agent; Medical countermeasures; Nerve agent; The Organisation for the Prohibition of Chemical Weapons

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Year:  2019        PMID: 30639304     DOI: 10.1016/j.tox.2019.01.004

Source DB:  PubMed          Journal:  Toxicology        ISSN: 0300-483X            Impact factor:   4.221


  3 in total

1.  Influence of Experimental End Point on the Therapeutic Efficacy of Essential and Additional Antidotes in Organophosphorus Nerve Agent-Intoxicated Mice.

Authors:  Jiri Kassa; Christopher M Timperley; Mike Bird; A Christopher Green; John E H Tattersall
Journal:  Toxics       Date:  2022-04-15

Review 2.  Counteracting poisoning with chemical warfare nerve agents.

Authors:  Nikolina Maček Hrvat; Zrinka Kovarik
Journal:  Arh Hig Rada Toksikol       Date:  2020-12-31       Impact factor: 2.078

3.  Assessment of four organophosphorus pesticides as inhibitors of human acetylcholinesterase and butyrylcholinesterase.

Authors:  Tena Čadež; Dora Kolić; Goran Šinko; Zrinka Kovarik
Journal:  Sci Rep       Date:  2021-11-02       Impact factor: 4.379

  3 in total

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