| Literature DB >> 30636576 |
Seyed A Javadinia1,2, Soodabeh Shahidsales2, Azar Fanipakdel2, Asma Mostafapour3, Mona Joudi-Mashhad2, Gordon A Ferns4, Amir Avan3.
Abstract
The Phosphatidylinositol 3-kinase/AKT/Mammalian Target of Rapamycin (PI3K/AKT/mTOR) pathway has a critical regulatory role in cell biology including translation, transcription, and autophagy. Dysregulation of this pathway is involved in the pathogenesis, development, and prognosis of esophageal cancer that has been assessed in the recent years and its potential as a target in therapy. This report summarizes the current knowledge about PI3K/AKT/mTOR pathway and its cross-talk with a focus on the value of targeting this pathway as a potential therapeutic target in the treatment of esophageal cancer. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.Entities:
Keywords: PI3K/AKT/mTOR pathway; esophageal cancer; microRNAs; rapamycin; transcription; translation.
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Year: 2018 PMID： 30636576 DOI： 10.2174/1381612825666190110143258
Source DB: PubMed Journal: Curr Pharm Des ISSN： 1381-6128 Impact factor: 3.116