| Literature DB >> 30636404 |
Weibin Liang1, Huoshu Xu2, Francesco Carraro, Natasha K Maddigan1, Qiaowei Li2, Stephen G Bell1, David M Huang1, Andrew Tarzia1, Marcello B Solomon1, Heinz Amenitsch, Lisa Vaccari3, Christopher J Sumby1, Paolo Falcaro1, Christian J Doonan1.
Abstract
Encapsulation of biomacromolecules in metal-organic frameworks (MOFs) can preserve biological functionality in harsh environments. Despite the success of this approach, termed biomimietic mineralization, limited consideration has been given to the chemistry of the MOF coating. Here, we show that enzymes encapsulated within hydrophilic MAF-7 or ZIF-90 retain enzymatic activity upon encapsulation and when exposed to high temperatures, denaturing or proteolytic agents, and organic solvents, whereas hydrophobic ZIF-8 affords inactive catalase and negligible protection to urease.Entities:
Mesh：
Substances：
Year: 2019 PMID： 30636404 DOI： 10.1021/jacs.8b10302
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419