Xiong-Fei Pan1,2, Li Tang3, Andy H Lee4, Colin Binns4, Chun-Xia Yang5, Zhu-Ping Xu6, Jian-Li Zhang7, Yong Yang8, Hong Wang9, Xin Sun10. 1. Chinese Evidence-based Medicine Center, Center for Clinical Epidemiology and Evidence-based Medicine, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, 610041, Sichuan, China. 2. Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 3. Department of Research and Education, Sichuan Jinxin Women's and Children's Hospital, Chengdu, China. 4. Department of Epidemiology and Biostatistics, School of Public Health, Curtin University, Perth, WA, Australia. 5. Department of Epidemiology and Biostatistics, West China School of Public Health, Sichuan University, Chengdu, Sichuan, China. 6. Shuangliu Maternal and Child Health Hospital, Chengdu, Sichuan, China. 7. Wenjiang Maternal and Child Health Hospital, Chengdu, Sichuan, China. 8. Longquan Maternal and Child Health Hospital, Chengdu, Sichuan, China. 9. Pidu Maternal and Child Health Hospital, Chengdu, Sichuan, China. 10. Chinese Evidence-based Medicine Center, Center for Clinical Epidemiology and Evidence-based Medicine, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu, 610041, Sichuan, China. sunx79@hotmail.com.
Abstract
BACKGROUND: Fetal macrosomia, defined as birth weight equal or over 4000 g, is a major concern for both neonatal and maternal health. A rapid increasing trend in fetal macrosomia is observed in different regions of China. We aimed to examine the association between fetal macrosomia and risk of childhood obesity in Western China. METHODS: All macrosomic live singletons (≥ 4000 g), and a random sample of singletons with normal birth weight (2500-3999 g) born in four districts of Chengdu, Western China, in 2011 were included in the cohort study. Maternal demographics, obstetric factors, labor and delivery summary at baseline were extracted from the Chengdu Maternal and Child Health Management System. Anthropometric measurements before 3 years and infant feeding information at around 6 months were also collected. Childhood obesity under 3 years was primarily defined as a weight-for-length/height z score ≥ 1.645 using the WHO growth reference. Secondary definitions were based on weight-for-age and body mass index (BMI)-for-age over the same cut-offs. RESULTS: A total of 1767 infants were included in the analyses, of whom 714 were macrosomic. After controlling for maternal age, parity, gestational age and anemia at the first antenatal visit, pre-pregnancy BMI, gestational weight gain, gestational age at birth, baby age and sex, and breastfeeding practices at 6 months, the risk of childhood obesity defined according to weight-for-length/height among macrosomic babies was 1.90 (95% confidence interval 1.04-3.49) times that of babies with normal birth weight. The risk of childhood obesity for macrosomic babies was 3.74 (1.96-7.14) and 1.64 (0.89-3.00) times higher based on weight-for-age and BMI-for-age, respectively. CONCLUSION: Fetal macrosomia is associated with increased risk of obesity in children under 3 years in Western China.
BACKGROUND:Fetal macrosomia, defined as birth weight equal or over 4000 g, is a major concern for both neonatal and maternal health. A rapid increasing trend in fetal macrosomia is observed in different regions of China. We aimed to examine the association between fetal macrosomia and risk of childhood obesity in Western China. METHODS: All macrosomic live singletons (≥ 4000 g), and a random sample of singletons with normal birth weight (2500-3999 g) born in four districts of Chengdu, Western China, in 2011 were included in the cohort study. Maternal demographics, obstetric factors, labor and delivery summary at baseline were extracted from the Chengdu Maternal and Child Health Management System. Anthropometric measurements before 3 years and infant feeding information at around 6 months were also collected. Childhood obesity under 3 years was primarily defined as a weight-for-length/height z score ≥ 1.645 using the WHO growth reference. Secondary definitions were based on weight-for-age and body mass index (BMI)-for-age over the same cut-offs. RESULTS: A total of 1767 infants were included in the analyses, of whom 714 were macrosomic. After controlling for maternal age, parity, gestational age and anemia at the first antenatal visit, pre-pregnancy BMI, gestational weight gain, gestational age at birth, baby age and sex, and breastfeeding practices at 6 months, the risk of childhood obesity defined according to weight-for-length/height among macrosomic babies was 1.90 (95% confidence interval 1.04-3.49) times that of babies with normal birth weight. The risk of childhood obesity for macrosomic babies was 3.74 (1.96-7.14) and 1.64 (0.89-3.00) times higher based on weight-for-age and BMI-for-age, respectively. CONCLUSION:Fetal macrosomia is associated with increased risk of obesity in children under 3 years in Western China.
Authors: Bao-Ying Feng; Yang Peng; Jun Liang; Li Wu; Qun-Jiao Jiang; Shun Liu; Xiao-Yun Zeng; Dong-Ping Huang; Xiao-Qiang Qiu; Han Li Journal: Curr Med Sci Date: 2021-04-20
Authors: Ana Ballesta-Castillejos; Juan Gómez-Salgado; Julián Rodríguez-Almagro; Inmaculada Ortiz-Esquinas; Antonio Hernández-Martínez Journal: J Clin Med Date: 2020-03-05 Impact factor: 4.241
Authors: Alicia K Peterson; Claudia M. Toledo-Corral; Thomas A Chavez; Christine H Naya; Mark Johnson; Sandrah P Eckel; Deborah Lerner; Brendan H Grubbs; Shohreh F Farzan; Genevieve F Dunton; Theresa M Bastain; Carrie V Breton Journal: Int J Environ Res Public Health Date: 2020-09-21 Impact factor: 3.390