Hyun Su Kim1, Young Cheol Yoon2,3, Byung-Ok Choi4, Wook Jin5, Jang Gyu Cha6, Jae-Hun Kim1. 1. Department of Radiology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, 81 Ilwon-Ro, Gangnam-gu, Seoul, 135-710, South Korea. 2. Department of Radiology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, 81 Ilwon-Ro, Gangnam-gu, Seoul, 135-710, South Korea. youngcheol.yoon@gmail.com. 3. Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, South Korea. youngcheol.yoon@gmail.com. 4. Department of Neurology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, South Korea. 5. Department of Radiology, Kyung Hee University Hospital at Gangdong, Seoul, South Korea. 6. Department of Radiology, Soonchunhyang University Bucheon Hospital, Bucheon, South Korea.
Abstract
OBJECTIVES: This study aimed to evaluate whether diffusion tensor imaging (DTI) parameters and cross-sectional area (CSA) can differentiate between the sciatic nerve of Charcot-Marie-Tooth (CMT) disease type I (demyelinating form) patients and that of controls. METHODS: This prospective comparison study included 18 CMT type I patients and 18 age/sex-matched volunteers. Magnetic resonance imaging including DTI and axial T2-weighted Dixon sequence was performed for each subject. Region of interest analysis was independently performed by two radiologists on each side of the sciatic nerve at four levels: hamstring tendon origin (level 1), lesser trochanter of the femur (level 2), gluteus maximus tendon insertion (level 3), and mid-femur (level 4). Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were calculated. The CSA of the sciatic nerve bundle was measured using axial water-only image at each level. Comparisons of DTI parameters between the two groups were performed using the two-sample t test and Mann-Whitney U test. Interobserver agreement analysis was also conducted. RESULTS: Interobserver agreement was excellent for all DTI parameter analyses. FA was significantly lower at all four levels in CMT patients than controls. RD, MD, and CSA were significantly higher at all four levels in CMT patients. AD was significantly higher at level 2 in CMT patients. CONCLUSION: DTI assessment of the sciatic nerve is reproducible and can discriminate the demyelinating nerve pathology of CMT type I patients from normal nerves. The CSA of the sciatic nerve is also a potential parameter for diagnosing nerve abnormality in CMT type I patients. KEY POINTS: • Diffusion tensor imaging parameters of the sciatic nerve at proximal to mid-femur level revealed significant differences between the Charcot-Marie-Tooth disease patients and controls. • The cross-sectional area of the sciatic nerve was significantly larger in the Charcot-Marie-Tooth disease patients. • Interobserver agreement was excellent (intraclass coefficient > 0.8) for all diffusion tensor imaging parameter analyses.
OBJECTIVES: This study aimed to evaluate whether diffusion tensor imaging (DTI) parameters and cross-sectional area (CSA) can differentiate between the sciatic nerve of Charcot-Marie-Tooth (CMT) disease type I (demyelinating form) patients and that of controls. METHODS: This prospective comparison study included 18 CMT type Ipatients and 18 age/sex-matched volunteers. Magnetic resonance imaging including DTI and axial T2-weighted Dixon sequence was performed for each subject. Region of interest analysis was independently performed by two radiologists on each side of the sciatic nerve at four levels: hamstring tendon origin (level 1), lesser trochanter of the femur (level 2), gluteus maximus tendon insertion (level 3), and mid-femur (level 4). Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were calculated. The CSA of the sciatic nerve bundle was measured using axial water-only image at each level. Comparisons of DTI parameters between the two groups were performed using the two-sample t test and Mann-Whitney U test. Interobserver agreement analysis was also conducted. RESULTS: Interobserver agreement was excellent for all DTI parameter analyses. FA was significantly lower at all four levels in CMTpatients than controls. RD, MD, and CSA were significantly higher at all four levels in CMTpatients. AD was significantly higher at level 2 in CMTpatients. CONCLUSION: DTI assessment of the sciatic nerve is reproducible and can discriminate the demyelinating nerve pathology of CMT type Ipatients from normal nerves. The CSA of the sciatic nerve is also a potential parameter for diagnosing nerve abnormality in CMT type Ipatients. KEY POINTS: • Diffusion tensor imaging parameters of the sciatic nerve at proximal to mid-femur level revealed significant differences between the Charcot-Marie-Tooth diseasepatients and controls. • The cross-sectional area of the sciatic nerve was significantly larger in the Charcot-Marie-Tooth diseasepatients. • Interobserver agreement was excellent (intraclass coefficient > 0.8) for all diffusion tensor imaging parameter analyses.
Authors: Sheng-Kwei Song; Jun Yoshino; Tuan Q Le; Shiow-Jiuan Lin; Shu-Wei Sun; Anne H Cross; Regina C Armstrong Journal: Neuroimage Date: 2005-05-15 Impact factor: 6.556
Authors: David N Loy; Joong Hee Kim; Mingqiang Xie; Robert E Schmidt; Kathryn Trinkaus; Sheng-Kwei Song Journal: J Neurotrauma Date: 2007-06 Impact factor: 5.269
Authors: Fabian Preisner; Rouven Behnisch; Véronique Schwehr; Tim Godel; Daniel Schwarz; Olivia Foesleitner; Philipp Bäumer; Sabine Heiland; Martin Bendszus; Moritz Kronlage Journal: Front Neurosci Date: 2022-02-16 Impact factor: 4.677
Authors: Hye Jin Kim; Sang Beom Kim; Hyun Su Kim; Hye Mi Kwon; Jae Hong Park; Ah Jin Lee; Si On Lim; Soo Hyun Nam; Young Bin Hong; Ki Wha Chung; Byung-Ok Choi Journal: Mol Genet Genomic Med Date: 2022-01-19 Impact factor: 2.183