Iván Galtier1, Antonieta Nieto2, Jesús N Lorenzo3, José Barroso2. 1. School of Psychology, University of La Laguna, 38205, La Laguna, Tenerife, Spain. igaltier@ull.edu.es. 2. School of Psychology, University of La Laguna, 38205, La Laguna, Tenerife, Spain. 3. Departament of Neurology, N.S. La Candelaria University Hospital, 38010, La Laguna, Tenerife, Spain.
Abstract
INTRODUCTION: Increasing evidence suggests that subjective cognitive decline is associated with Alzheimer's disease pathology and with an increased risk for future dementia development. However, the clinical value of subjective cognitive decline in Parkinson's disease (PD-SCD) is unclear. The aim of the present work was to characterize PD-SCD and its progression to dementia. METHODS: Forty-three PD patients and twenty normal controls were evaluated with a neuropsychological protocol. Patients were classified as PD-SCD and PD with mild cognitive impairment (PD-MCI). Follow-up assessment was conducted to a mean of 7.5 years after the baseline. RESULTS: Thirteen patients were diagnosed with PD-SCD (30.2%) and 22 patients were classified as PD-MCI (51.2%) at the baseline. Difficulties in language (60.5%) and memory (51.5%) were the most frequent cognitive complaints. PD-MCI showed alterations in processing speed, executive functions, visuospatial skills, memory and language. No significant differences were found between normal controls and PD-SCD in any of the neuropsychological measures. Conversion to clinically diagnosed dementia during the follow-up was 50% in PD-MCI, 33.3% in PD-SCD and 14.3% in patients without subjective cognitive complaints. Discriminant function analyses and logistic regression analyses revealed that language domain and, especially memory domain are good predictors of dementia. CONCLUSIONS: The present investigation is the first to conduct a long-term follow-up study of PD-SCD and its relationship with the development of dementia. The results provide relevant data about the characterization of SCD in PD patients and show that PD-SCD is a risk factor for progression to dementia.
INTRODUCTION: Increasing evidence suggests that subjective cognitive decline is associated with Alzheimer's disease pathology and with an increased risk for future dementia development. However, the clinical value of subjective cognitive decline in Parkinson's disease (PD-SCD) is unclear. The aim of the present work was to characterize PD-SCD and its progression to dementia. METHODS: Forty-three PDpatients and twenty normal controls were evaluated with a neuropsychological protocol. Patients were classified as PD-SCD and PD with mild cognitive impairment (PD-MCI). Follow-up assessment was conducted to a mean of 7.5 years after the baseline. RESULTS: Thirteen patients were diagnosed with PD-SCD (30.2%) and 22 patients were classified as PD-MCI (51.2%) at the baseline. Difficulties in language (60.5%) and memory (51.5%) were the most frequent cognitive complaints. PD-MCI showed alterations in processing speed, executive functions, visuospatial skills, memory and language. No significant differences were found between normal controls and PD-SCD in any of the neuropsychological measures. Conversion to clinically diagnosed dementia during the follow-up was 50% in PD-MCI, 33.3% in PD-SCD and 14.3% in patients without subjective cognitive complaints. Discriminant function analyses and logistic regression analyses revealed that language domain and, especially memory domain are good predictors of dementia. CONCLUSIONS: The present investigation is the first to conduct a long-term follow-up study of PD-SCD and its relationship with the development of dementia. The results provide relevant data about the characterization of SCD in PDpatients and show that PD-SCD is a risk factor for progression to dementia.
Authors: Rachael Purri; Laura Brennan; Jacqueline Rick; Sharon X Xie; Benjamin L Deck; Lana M Chahine; Nabila Dahodwala; Alice Chen-Plotkin; John E Duda; James F Morley; Rizwan S Akhtar; John Q Trojanowski; Andrew Siderowf; Daniel Weintraub Journal: Mov Disord Date: 2020-06-10 Impact factor: 10.338
Authors: Anja Ophey; Fabian Krohm; Carsten Eggers; Franziska Maier; Elke Kalbe; Andrea Greuel; Alexander Drzezga; Marc Tittgemeyer; Lars Timmermann; Frank Jessen Journal: Neurol Sci Date: 2021-11-25 Impact factor: 3.830
Authors: Diego Santos García; María Álvarez Sauco; Matilde Calopa; Fátima Carrillo; Francisco Escamilla Sevilla; Eric Freire; Rocío García Ramos; Jaime Kulisevsky; Juan Carlos Gómez Esteban; Inés Legarda; María Rosario Isabel Luquín; Juan Carlos Martínez Castrillo; Pablo Martínez-Martin; Irene Martínez-Torres; Pablo Mir; Ángel Sesar Ignacio Journal: Diagnostics (Basel) Date: 2021-12-28
Authors: Rachael A Lawson; Caroline H Williams-Gray; Marta Camacho; Gordon W Duncan; Tien K Khoo; David P Breen; Roger A Barker; Lynn Rochester; David J Burn; Alison J Yarnall Journal: J Parkinsons Dis Date: 2021 Impact factor: 5.568